Ketoconazole resistant Candida albicans is sensitive to a wireless electroceutical wound care dressing

Khona, Dolly; Roy, Sashwati; Ghatak, Subhadip; Huang, Kaixiang; Jagdale, Gargi S.; Baker, Lane A.; Sen, Chandan K.

doi:10.1016/j.bioelechem.2021.107921

Cited by 13 publications

(11 citation statements)

References 85 publications

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“…In addition to promoting cell migration, the hydro‐activated microcell batteries can promote wound healing by providing excellent antimicrobial efficacy. [ 47,48 ] Therefore, the antibacterial properties of TPU/Cotton, Ag@TPU/Cotton, Zn@TPU/Cotton, and Ag/Zn@TPU/Cotton against E. coli and S. aureus were tested using the agar diffusion method. The TPU/Cotton showed no antibacterial activity against E. coli or S. aureus (Figure S2a, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing

Li,

Zhao,

Feng

et al. 2023

Adv Materials Technologies

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Exudate management and bioelectric signals are critical to promoting wound healing. In this study, the thermoplastic polyurethane (TPU) nanofiber is directly electrospun on the cotton microfibers (Cotton) to prepare a Janus dressing (TPU/Cotton), which can unidirectionally drain the excess exudate. Then, Ag/Zn dot electrodes are deposited on the TPU layer, which can produce an electric field penetrating the wound when activated by wound exudate. The hydro‐activated Ag/Zn's electrical stimulation (ES) can promote the migration of fibroblast cells and shows excellent antibacterial activity against E. coli and S. aureus. Furthermore, in vivo experiments show that the exudate management coupled with ES accelerated wound healing at multiple stages by promoting re‐epithelization, collagen deposition, and vascularization. Moreover, the Ag/Zn@TPU/Cotton dressing shows excellent biocompatibility in the vitro cytotoxicity experiments. These findings may shed some light on developing the next generation of wound dressings with self‐activated electrical stimulation and exudate management.

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Section: Resultsmentioning

confidence: 99%

Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing

Li,

Zhao,

Feng

et al. 2023

Adv Materials Technologies

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“…Previous work from our laboratory has established the effectiveness of electroceutical principles as an alternative to pharmacological approaches in managing planktonic microbial pathogens and complex polymicrobial biofilms 18 , 20 , 21 , 23 , 24 . Viruses are known to rely on electrostatic interactions for optimal virion assembly and attachment 13 , 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Electroceuticals have generated renewed interest in the health care industry 28 . The fabric tested in this work consists of only silver and zinc dots on polyester fabric that forms a redox couple 18 – 23 . Zeta potential of a particle determines its electrostatic interactions in particle dispersions and, as such, is an important determinant of the stability of viral particles 29 .…”

Section: Discussionmentioning

confidence: 99%

“…We have co-developed a wireless electroceutical fabric for use as wound care dressing 18 – 22 . This dressing, upon contact with bodily fluids or other aqueous wetting media, generates weak electric field which is effective in managing biofilm infection and improving wound healing 18 , 20 , 21 , 23 . The dressing is currently FDA cleared and in clinical trial (NCT04079998).…”

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confidence: 99%

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Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact

Ghatak

Khona

Sen

et al. 2021

Sci Rep

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Coronavirus with intact infectivity attached to PPE surfaces pose significant threat to the spread of COVID-19. We tested the hypothesis that an electroceutical fabric, generating weak potential difference of 0.5 V, disrupts the infectivity of coronavirus upon contact by destabilizing the electrokinetic properties of the virion. Porcine respiratory coronavirus AR310 particles (105) were placed in direct contact with the fabric for 1 or 5 min. Following one minute of contact, zeta potential of the porcine coronavirus was significantly lowered indicating destabilization of its electrokinetic properties. Size-distribution plot showed appearance of aggregation of the virus. Testing of the cytopathic effects of the virus showed eradication of infectivity as quantitatively assessed by PI-calcein and MTT cell viability tests. This work provides the rationale to consider the studied electroceutical fabric, or other materials with comparable property, as material of choice for the development of PPE in the fight against COVID-19.

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“…37,38 When a wound that disrupts the epithelial barrier occurs, the wound surface immediately generates an EF pointing from the edge to the center. 39,40 When Ag/Zn@PLA dressings come into contact with blood or wound extrusions, a set of redox reactions between the Ag and Zn electrodes are expected to occur: 41,42 Ag electrode:…”

Section: Electric Activity and Cell Migration Of Ag/zn@plamentioning

confidence: 99%

Electroactive nanofibrous membrane with temperature monitoring for wound healing

Yang

Wang

et al. 2023

RSC Adv.

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Ketoconazole resistant Candida albicans is sensitive to a wireless electroceutical wound care dressing

Cited by 13 publications

References 85 publications

Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing

Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing

Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact

Electroactive nanofibrous membrane with temperature monitoring for wound healing

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