Ketoconazole loaded quaternized chitosan nanoparticles-PVA film: preparation and evaluation

Dhiman, Priya; Bhatia, Meenakshi

doi:10.1007/s00289-020-03500-0

Cited by 8 publications

(4 citation statements)

References 47 publications

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“…Furthermore, the surface charge of NPs decreased upon loading of BV, which was later confirmed by the FTIR results. All of these results were in accordance with previous studies 25,26 .…”

Section: Discussionsupporting

confidence: 93%

Bee venom as an alternative for antibiotics against Staphylococcus aureus infections

Ahmed

Gouda

Elmligy

et al. 2023

Sci Rep

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The misuse of antibiotics has led to antibiotic-resistant bacterial strains, making it even harder to combat and eliminate their infections. Staphylococcus aureus causes various adverse infections and diseases, including skin abscesses, bloodstream infections, pneumonia, and joint infections. In this study, we aimed to test the cytotoxic and antibacterial effects of bee venom-loaded chitosan nanoparticles (BV-loaded CS-NPs) in comparison to gamma-irradiated BV and native BV from Apis mellifera. The physiochemical characterizations of our treatments were determined by Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscope (TEM), zeta-potential, release rate, and Encapsulation Efficiency (EE). Our study was conducted on both levels, in-vitro and in-vivo. For the in-vitro study, a bacterial model of Staphylococcus aureus with an ATCC number of 6538 was grown in tryptic soy agar (TSA) medium, and the inhibition zones of our drug candidates were measured with the appropriate statistical analysis performed. For the in-vivo study, levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), Creatinine, Urea, and interleukin 6 (IL-6) were analyzed. BV-loaded CS-NPs showed relatively better results than the other alternatives, which are native BV and gamma-irradiated BV. The results showed that the antibacterial effect of BV-loaded CS-NPs was greater than the alternatives. Furthermore, its cytotoxic effect was far less than the native and irradiated bee venom. These outcomes ensure that loading BV on CS-NPs makes it a promising drug candidate for an antibiotic alternative with minimal cytotoxicity and enhanced antibacterial activity.

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“…Furthermore, the surface charge of NPs decreased upon loading of BV, which was later confirmed by the FTIR results. All of these results were in accordance with previous studies 25,26 .…”

Section: Discussionsupporting

confidence: 93%

Bee venom as an alternative for antibiotics against Staphylococcus aureus infections

Ahmed

Gouda

Elmligy

et al. 2023

Sci Rep

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“…The results revealed that the drug entrapped as nanoparticles in the system was responsible for the sustained release. [ 100 ] The study conducted by Macleod et al., [ 101 ] confirmed that a mixture of pectin, chitosan, and hydroxypropyl methylcellulose has the potential to form films capable of attaining bimodal drug delivery of paracetamol. The rate of release of the drug could be manipulated by altering the material properties of the film and concentration of the bacterial enzymes.…”

Section: Chitosan Films In Drug Delivery Applicationsmentioning

confidence: 99%

Chitosan‐Based Films in Drug Delivery Applications

2022

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The idea of controlled release of the pharmaceutical active ingredients in the human body has become a major thrust for designing sophisticated drug delivery systems. The mandatory requirement for developing these delivery vehicles is to support the delivery of pharmaceutical drugs in a pharmokinetically controlled manner. Though a variety of synthetic polymers address the above mentioned conditions, their toxicity and high cost have ultimately hampered their role. Consequently, natural polymers owing to their biocompatibility, biodegradability, and nontoxicity can be used for the successful designing of drug delivery supports. One such natural polymer extracted from crustaceans, is chitosan. Chitosan can be used in drug delivery in various forms like hydrogels, nanoparticles, nanofibers, films, etc. This review presents the properties of chitosan films and their pivotal role in various drug delivery approaches.

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“…[28][29][30][31] Meanwhile, wound dressings with inherent antibacterial ability represent better performance than broad-spectrum antibiotics in anti-wound infection. 28,32 Quaternized chitosan (QCS) not only exhibits more positive charges, which endow better antibacterial properties, 33,34 but also exhibits better water solubility, hemostatic properties, and biocompatibility, 35,36 suggesting that it has broader application prospects. 27,37 Thus, developing multifunctional CNT-enhanced QCS based temperature-sensitive nanocomposite hydrogels in wound dressings is highly desirable.…”

Section: Introductionmentioning

confidence: 99%

Smart DEA–QCGM–CNT hydrogels with temperature- and NIR-responsive behavior achieved by the synergy between CNT and QCGM for wound dressing

Zhong

Long

et al. 2022

Mater. Adv.

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Ketoconazole loaded quaternized chitosan nanoparticles-PVA film: preparation and evaluation

Cited by 8 publications

References 47 publications

Bee venom as an alternative for antibiotics against Staphylococcus aureus infections

Bee venom as an alternative for antibiotics against Staphylococcus aureus infections

Chitosan‐Based Films in Drug Delivery Applications

Smart DEA–QCGM–CNT hydrogels with temperature- and NIR-responsive behavior achieved by the synergy between CNT and QCGM for wound dressing

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