Ketoconazole

Jones, H. E.

doi:10.1001/archderm.118.4.217

Cited by 8 publications

(8 citation statements)

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“…There are multiple reasons for decreased appetite or lethargy in patients, and the dogs were often receiving multiple medications; therefore, it was not possible to determine whether these signs were unequivocally related to ketoconazole therapy. However, these adverse events are similar to those reported in humans treated with ketoconazole 19,30–34 and correlate well with clinical information in the veterinary literature 3,13,22,23…”

Section: Discussionsupporting

confidence: 83%

Adverse effects of ketoconazole in dogs – a retrospective study

Mayer

Glos

Schmid³

et al. 2008

Veterinary Dermatology

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Although ketoconazole has been used extensively in dogs for the treatment of various fungal infections, information about adverse effects is mainly anecdotal. Common adverse effects in humans include dose-dependant anorexia, nausea and vomiting, allergic rashes and pruritus. Drug-induced hepatitis is very rare, but potentially fatal. The aim of this study was to evaluate the type and frequency of adverse effects associated with ketoconazole therapy in dogs treated for skin diseases and any possible influence of dosage, duration of therapy, signalment or concurrent medication. The medical records of 632 dogs treated with ketoconazole (2.6-33.4 mg/kg) were reviewed. Adverse effects occurred in 14.6% (92 dogs) and included vomiting (7.1%), anorexia (4.9%), lethargy (1.9%), diarrhea (1.1%), pruritus (0.6%), erythema (0.3%) and other adverse effects (2.5%). Of the dogs with other adverse effects, four of 16 (25%) were ataxic and three of these received concurrent ivermectin. Adverse effects were significantly more often recorded in dogs concurrently treated with ciclosporin (P = 0.034) or ivermectin (P = 0.007). Increased liver enzyme levels were reported rarely, and icterus was not seen in any of the dogs. However, monitoring liver enzymes during therapy is recommended, although this might not necessarily prevent severe idiosyncratic hepatotoxicity.

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Section: Discussionsupporting

confidence: 83%

Adverse effects of ketoconazole in dogs – a retrospective study

Mayer

Glos

Schmid³

et al. 2008

Veterinary Dermatology

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“…De Mor agas et al [11] have reported a case of der mal altemariasis cured with miconazole. From the result attained in the present case and because of its broad spectrum of action on superficial and deep mycosis [26], kéto conazole is supposed to represent the drug of choice.…”

Section: Commentsmentioning

confidence: 74%

Dermal Altemariasis in a Kidney Transplant Recipient

Bourlond¹,

Alexandre

1984

Dermatology

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“…The degree of nail affection did not significantly change the results for the com bined treatment; 68% of the nails with less than 50% changes were cured compared to 60% with more than 50% involvement, while the Swedish study on local treatment reported 68% cure of nails with less than 50% involvement and only 15% cure of nails with more than 75% [8], Our patients experienced side effects like gastrointestinal problems and elevated liver enzymes. The hepatotoxic effects may be se rious [3,5], especially in patients with previ ous hepatic disease. With this reservation.…”

Section: Discussionmentioning

confidence: 99%

“…Griseofulvin treatment has at best brought about a cure in 17% [1], Even treatment periods of 1-2 years have been unsuccessful and true resistance of dermatophytes to griseofulvin has also been reported [2], Kétoconazole (imidazole derivative) has recently been introduced as an oral, broad-spectrum and efficient anti fungal drug [3]. Treatment must be contin ued for several months because toenails are slow-growing [4], Liver complications may occur even after short periods of kétocon azole therapy [3,5]. We therefore felt it val uable to study the effect of partial removal of the infectious focus, combined with a shorter course of kétoconazole treatment.…”

Section: Introductionmentioning

confidence: 99%

<i>Trichophyton</i>-<i>rubrum</i>-lnfected Toenails Treated with Ketoconazole and Partial Nail Avulsion

Kavli¹,

Midelfart²,

Moseng³

et al. 1984

Dermatology

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30 patients with totally 178 toenails infected with Trichophyton rubrum were randomly treated with ketoconazole alone for 4 months (group A) or in combination with chemical nail avulsion (group B). Of the 14 patients in group A who completed the treatment, 4 (28%) were cured 6 months later, compared to 8 (53%) of 15 patients in group B. In 4 cases, transient elevated hepatofunction enzymes occurred. Gastrointestinal disturbances caused withdrawal in 1 case.

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Ketoconazole

Cited by 8 publications

References 0 publications

Adverse effects of ketoconazole in dogs – a retrospective study

Adverse effects of ketoconazole in dogs – a retrospective study

Dermal Altemariasis in a Kidney Transplant Recipient

<i>Trichophyton</i>-<i>rubrum</i>-lnfected Toenails Treated with Ketoconazole and Partial Nail Avulsion

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