1982
DOI: 10.1001/archderm.118.4.217
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Ketoconazole

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Cited by 8 publications
(8 citation statements)
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“…There are multiple reasons for decreased appetite or lethargy in patients, and the dogs were often receiving multiple medications; therefore, it was not possible to determine whether these signs were unequivocally related to ketoconazole therapy. However, these adverse events are similar to those reported in humans treated with ketoconazole 19,30–34 and correlate well with clinical information in the veterinary literature 3,13,22,23…”
Section: Discussionsupporting
confidence: 83%
“…There are multiple reasons for decreased appetite or lethargy in patients, and the dogs were often receiving multiple medications; therefore, it was not possible to determine whether these signs were unequivocally related to ketoconazole therapy. However, these adverse events are similar to those reported in humans treated with ketoconazole 19,30–34 and correlate well with clinical information in the veterinary literature 3,13,22,23…”
Section: Discussionsupporting
confidence: 83%
“…De Mor agas et al [11] have reported a case of der mal altemariasis cured with miconazole. From the result attained in the present case and because of its broad spectrum of action on superficial and deep mycosis [26], kéto conazole is supposed to represent the drug of choice.…”
Section: Commentsmentioning
confidence: 74%
“…The degree of nail affection did not significantly change the results for the com bined treatment; 68% of the nails with less than 50% changes were cured compared to 60% with more than 50% involvement, while the Swedish study on local treatment reported 68% cure of nails with less than 50% involvement and only 15% cure of nails with more than 75% [8], Our patients experienced side effects like gastrointestinal problems and elevated liver enzymes. The hepatotoxic effects may be se rious [3,5], especially in patients with previ ous hepatic disease. With this reservation.…”
Section: Discussionmentioning
confidence: 99%
“…Griseofulvin treatment has at best brought about a cure in 17% [1], Even treatment periods of 1-2 years have been unsuccessful and true resistance of dermatophytes to griseofulvin has also been reported [2], Kétoconazole (imidazole derivative) has recently been introduced as an oral, broad-spectrum and efficient anti fungal drug [3]. Treatment must be contin ued for several months because toenails are slow-growing [4], Liver complications may occur even after short periods of kétocon azole therapy [3,5]. We therefore felt it val uable to study the effect of partial removal of the infectious focus, combined with a shorter course of kétoconazole treatment.…”
Section: Introductionmentioning
confidence: 99%