Dermal Altemariasis in a Kidney Transplant Recipient

Bourlond, A; Alexandre, Guy P.

doi:10.1159/000249690

Cited by 31 publications

(8 citation statements)

References 8 publications

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“…Also, a solitary case report on the successful use of intravenous caspofungin for the treatment of cutaneous alternariosis has been described . As clinical trials are lacking, the optimal treatment strategy for patients with deep‐seated Alternaria infections remains unclear . Combination antifungal therapy can be recommended in disseminated cases .…”

Section: Black Fungal Species With Clinical Relevancementioning

confidence: 99%

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi

Chowdhary

Meis

Guarro

et al. 2014

Clinical Microbiology and Infection

290

253

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The aetiological agents of many invasive fungal infections are saprobes and opportunistic pathogens. Some of these fungi are darkly pigmented due to melanin production and traditionally have been named 'dematiaceous'. The melanized fungi cause a wide array of clinical syndromes ranging from superficial to deep-seated infections. Diagnosis relies on histopathological examination of clinical specimens and on examination of cultures. Sequencing is recommended for accurate species identification, especially for unusual or newly described pathogens. In cases of mycetoma and chromoblastomycosis, pathognomonic histological findings are useful and the Fontana-Masson stain, specific for melanin, usually confirms the diagnosis. There are no standardized therapies but voriconazole, posaconazole and itraconazole demonstrate the most consistent in vitro activity against this group of fungi. Oral itraconazole has been considered the drug of choice, given the extensive clinical experience with this drug. However, voriconazole may presumably be superior for central nervous system infections because of its ability to achieve good levels in the cerebrospinal fluid. Posaconazole is a well-tolerated alternative drug, backed by less clinical experience but with excellent salvage treatment results after failure of other antifungals. Amphotericin B has been useful as alternative therapy in some cases. Combination antifungal therapy is recommended for cerebral abscesses when surgery is not possible and for disseminated infections in immunocompromised patients.

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Section: Black Fungal Species With Clinical Relevancementioning

confidence: 99%

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi

Chowdhary

Meis

Guarro

et al. 2014

Clinical Microbiology and Infection

290

253

View full text Add to dashboard Cite

show abstract

“…Skin manifestations range from papulonodular to ulcerative or vegetating lesions. Single or multiple lesions may be seen (21). Treatment consists of surgical excision in some cases, if nodules are limited, and/or systemic antifungal therapy; i.e.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Fungal Infections in Solid Organ Transplantation: A Case Series

Miele

Levy

Smith

et al. 2002

American Journal of Transplantation

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Cutaneous fungal infections in solid-organ transplant patients present in a variety of nonspecific ways, requiring a high index of suspicion to diagnose correctly. In the present series of four transplant recipients, subsequent primary cutaneous fungal infections presented as papules, plaques, ulcers and subcutaneous nodules. Transplantations included one cardiac, two renal and one renal-pancreatic transplant. Fungal infections were limited to the skin; there was no evidence of disseminated disease in any case. The pathogens isolated were Scedosporium apiospermum (Pseudallescheria boydii), Alternaria species, Aspergillus fumigatus, and a coelomycete in the Coniothyrium-Microsphaeropsis complex of dark molds. Individuals were successfully treated with surgical debridement, antifungal agents, and reduction of immunosuppressive therapy. All patients and allografts survived. Accurate diagnosis, aggressive surgery and appropriate antifungal therapy, combined with close outpatient follow-up, optimize the likelihood of a cure in a transplant population.

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“…More often chromoblastomycotic agents are described: Alternaria spp. [7], A. alternata [8,9] [ 19,201, E. spinifera [21], Phialophora parasitica [22], Phialemonium dimorphosporum or I? cuwatum and I?…”

Section: Discussionmentioning

confidence: 99%

Phaeohyphomycotic soft tissue disease caused by Pleurophomopsis lignicola in a kidney transplant patient

Farina

Punithaligham

Ruggenenti

et al. 1997

Journal of Medical Microbiology

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A 44-year-old immunocompromised man presented with multiple tissue abscesses, covering the entire left limb. A dematiaceous fungus compatible with Pleurophomopsis lignicola Petrak was isolated from the diseased tissue in pure culture. This is the second reported isolation of this fungus from man and the first report of fatal soft tissue infection. A detailed morphological description of the isolate is provided.

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Dermal Altemariasis in a Kidney Transplant Recipient

Cited by 31 publications

References 8 publications

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi

Primary Cutaneous Fungal Infections in Solid Organ Transplantation: A Case Series

Phaeohyphomycotic soft tissue disease caused by Pleurophomopsis lignicola in a kidney transplant patient

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