“…After oral administration, Wenting et al, 1984) and oral administration ketanserin is rapidly and completely absorbed. (Hedner et al, 1983;Trenk et al, 1983). Studies The absolute oral bioavailability is 50% on the pharmacokinetics and bioavailability of Reimann et al, 1983; ketanserin in young adult volunteers (Heykants Trenk et al, 1983) reflecting presystemic et al, 1986Reimann et al, 1983;Trenk et al, metabolism in the liver and involving the reduc-1983; Van Peer et al, 1986), the elderly tion of ketanserin to ketanserin-ol (Van Peer et (Kurowski, 1985), hypertensive patients (Persson al., 1986 negligible but ketanserin-ol excretion accounts for 13 to 17% of the ketanserin dose Van Peer et al, 1986).…”