Ketamine changes the local resting-state functional properties of anesthetized-monkey brain

Rao, Jia‐Sheng; Liu, Zuxiang; Zhao, Chen; Wei, Ruihan; Zhao, Wen; Tian, Peng-Yu; Zhou, Xia; Yang, Zhaoyang; Li, Xiaoguang

doi:10.1016/j.mri.2017.07.025

Cited by 17 publications

(15 citation statements)

References 50 publications

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“…Similarly to ALFF, and contrary to the majority of the other methods described here, ReHo is a measure that informs on the local signal coherence strength, but not of distal connectivity. The method has been effectively applied in rodents (Wu et al, 2017; and NHP (Rao et al, 2017), such as to describe anesthesia effects on the mouse brain (Wu et al, 2017). ReHo is also a low-level parameter and is relatively simple to interpret.…”

Section: Regional Homogeneitymentioning

confidence: 99%

Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization

Mandino

Cerri

Garin

et al. 2020

Front. Neuroinform.

100

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Animal whole-brain functional magnetic resonance imaging (fMRI) provides a noninvasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain. Animal fMRI studies have developed rapidly over the past years, fueled by the development of resting-state fMRI connectivity and genetically encoded neuromodulatory tools. Yet, comparisons between sites remain hampered by lack of standardization. Recently, we highlighted that mouse resting-state functional connectivity converges across centers, although large discrepancies in sensitivity and specificity remained. Here, we explore past and present trends within the animal fMRI community and highlight critical aspects in study design, data acquisition, and post-processing operations, that may affect the results and influence the comparability between studies. We also suggest practices aimed to promote the adoption of standards within the community and improve betweenlab reproducibility. The implementation of standardized animal neuroimaging protocols will facilitate animal population imaging efforts as well as meta-analysis and replication studies, the gold standards in evidence-based science.

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Section: Regional Homogeneitymentioning

confidence: 99%

Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization

Mandino

Cerri

Garin

et al. 2020

Front. Neuroinform.

100

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“…2,7,10,22 In addition, ketamine can cause changes in the brain, such as neuroplasticity and neuropoptosis in neonatal rhesus macaques, which may further explain the tolerance we observed. 6,33 The reliability of ketamine as an anesthetic is important for researchers and veterinarians that specialize in laboratory animal medicine, because it is commonly the drug of choice for short procedures, such as physical examinations. Our current results might explain why subsequent sedations with ketamine can be less effective and shorter duration and suggest that it may be beneficial to increase the dose of successive sedations or switch anesthetics in animals undergoing frequent sedations.…”

Section: Discussionmentioning

confidence: 99%

Ketamine Tolerance in Sprague–Dawley Rats after Chronic Administration of Ketamine, Morphine, or Cocaine

Gerb

Cook

Gochenauer³

et al. 2019

comp med

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Ketamine is one of the most commonly used anesthetics in human and veterinary medicine, but its clinical effectiveness is often compromised due to tolerance to its anesthetic effects. Although ketamine tolerance has been demonstrated in a number of behavioral measures, no published work has investigated tolerance to ketamine's anesthetic effects other than duration of anesthesia. In addition, a reported practice in anesthesiology is to alter anesthetic doses for procedures when the patient has a history of drug abuse. Empirically investigating the effects of administration of a drug of abuse on ketamine's potency and efficacy to produce anesthesia could help in the creation of anesthetic plans that maximize safety for both clinicians and patients. The goal of the current study was to test the effects of repeated administration of ketamine, morphine, or cocaine on ketamine's ability to produce anesthesia. In 2 studies, male Sprague-Dawley rats received daily injections of ketamine (32 or 100 mg/kg IP), morphine (3.2 or 5.6 mg/kg IP), or cocaine (3.2 or 10 mg/kg IP) for 14 consecutive days and then were tested on day 15 for ketamine-induced anesthesia by using a cumulative-dosing procedure (32 to 320 mg/kg IP). Chronic treatment with either ketamine or morphine-but not cocaine-produced tolerance to ketamine's anesthetic effects in a dose-dependent manner. These results suggest that ketamine's clinical effectiveness as an anesthetic will vary as a function of its history of use. Furthermore, given that chronic morphine administration produced tolerance to ketamine's anesthetic effects, various pain medications may reduce ketamine's effectiveness for anesthesia.

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“…Xylazine hydrochloride solution (0.1 mg/kg, im) was used to maintain the anesthesia. Physiological status was regularly monitored during the entire scanning period …”

Section: Methodsmentioning

confidence: 99%

“…Physiological status was regularly monitored during the entire scanning period. 35 image to generate a mask, which was then applied to all realigned EPI datasets. All realigning and registration processes mentioned above were iterated at least thrice.…”

Section: Animal Preparationmentioning

confidence: 99%

Image correction for diffusion tensor imaging of Rhesus monkey thoracic spinal cord

Rao

Liu

Zhao

et al. 2019

J of Medical Primatology

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Background: The relatively tiny spinal cord of non-human primate (NHP) causes increased challenge in diffusion tensor imaging (DTI) post-processing. This study aimed to establish a reliable correction strategy applied to clinical DTI images of NHP. Methods: Six normal and partial spinal cord injury (SCI) rhesus monkeys underwent 3T MR scanning. A correction strategy combining multiple iterations and non-rigid deformation was used for DTI image post-processing. Quantitative evaluations were then conducted to investigate effects of distortion correction.Results: After correction, longitudinal geometric distortion, global distortion, and residual distance errors were all significantly decreased (P < 0.05). Fractional anisotropy at the injured site was remarkably lower than that at the contralateral site (P = 0.0488) and was substantially lower than those at the adjacent superior (P = 0.0157) and inferior (P = 0.0128) areas at the same side. Conclusions:Our image correction strategy can improve the quality of the DTI images of NHP thoracic cords, contributing to the development of SCI preclinical research. K E Y W O R D S image correction strategy, non-human primates, preclinical research, spinal cord injury | 321 RAO et Al.

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Ketamine changes the local resting-state functional properties of anesthetized-monkey brain

Cited by 17 publications

References 50 publications

Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization

Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization

Ketamine Tolerance in Sprague–Dawley Rats after Chronic Administration of Ketamine, Morphine, or Cocaine

Image correction for diffusion tensor imaging of Rhesus monkey thoracic spinal cord

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