Keratosis lichenoides chronica treated with acitretin plus narrowband ultraviolet B phototherapy

Köseoğlu, Reşit Doğan; Sezer, Engin; Yuksek, Jale

doi:10.1111/j.1346-8138.2008.00439.x

Cited by 18 publications

(21 citation statements)

References 12 publications

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“…The treatment of KLC is difficult because the disease is resistant to many different therapies, including topical or systemic corticosteroids, methotrexate, cyclosporine, antibiotics, antimalarials, and sulfones. In some cases, partial responses have been reported with the use of PUVA, narrowband UV-B, and systemic retinoids (8). In the current case, generalized eruptions which were presumed to be induced by pyrazinamide, resolved after the administration of symptomatic treatment and the abandonment of the suspected drug without any further treatment.…”

Section: Casementioning

confidence: 63%

Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Zindancı¹,

Okur²,

Zemheri³

et al. 2014

Respir Case Rep

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Keratosis lichenoides chronica (KLC) is a rare and chronic skin disease characterized by erythema, keratotic and lichenoid papules are distributed symmetrically. The histological examination of KLC reveals lichenoid dermatitis with hyper and parakeratosis. Although the etiology and pathogenesis of KLC are unknown, it is suggested that KLC is a variant of lichen planus or lichenoid drug eruptions. We present a case of generalized KLC that occurred during antituberculosis therapy including isoniazid, rifampicin, ethambutol, and pyrazinamide and dramatically improved after cessation of therapy. We report this generalized KLC case in order to draw attention to the side effects that can be seen during tuberculosis treatment.

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Section: Casementioning

confidence: 63%

Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Zindancı¹,

Okur²,

Zemheri³

et al. 2014

Respir Case Rep

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“…The eyes can also be affected, with the most common problems being blepharitis, conjunctivitis, uveitis and iridocyclitis. 6 Reports exist of association with glomerulonephritis and lymphoproliferative disorders. In rare cases hoarseness, due to infiltration of the epiglottis, can be observed.…”

Section: Discussionmentioning

confidence: 99%

“…3,5 The most common nail changes are yellowing, thickening and hyperkeratosis of the nail bed. 3,6 This skin problem can also be associated with oral manifestations in 50% of cases presenting as recurrent aphthous ulcers and lesions. 6 In relation to genital lesions, keratotic papules can be found on the scrotum and penis as well as chronic balanitis and phimosis.…”

Section: Discussionmentioning

confidence: 99%

“…3,6 This skin problem can also be associated with oral manifestations in 50% of cases presenting as recurrent aphthous ulcers and lesions. 6 In relation to genital lesions, keratotic papules can be found on the scrotum and penis as well as chronic balanitis and phimosis. The eyes can also be affected, with the most common problems being blepharitis, conjunctivitis, uveitis and iridocyclitis.…”

Section: Discussionmentioning

confidence: 99%

“…Topical treatments are usually ineffective, as well as treatment with systemic steroids, sulfones, methotrexate, antimalarial agents, radiation therapy and cyclosporine. 5,6,9 Acitretin, isotretinoin, etretinate, psoralen and UVA (PUVA), Re-PUVA and topical cacipotriol have all been used, with different results. 6 A few reports exist of good results with re-PUVA, acitretin-UVB + NB and also with efalizumab, but further studies are called for regarding these therapies.…”

Section: Discussionmentioning

confidence: 99%

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Queratose liquenoide crônica: relato de caso

Martins

Horne

Júnior

et al. 2011

An. Bras. Dermatol.

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Keratosis lichenoides chronica or Nekam´s disease is a rare mucocutaneous dermatosis characterized by keratinization. It is chronic and progressive usually affecting individuals aged 20-40 years. Around 70 cases have been reported in the literature. Due to the rarity of this condition and the lack of effective treatment, it is a difficult disease to manage. In the case described below we present a 42-yearold patient with violaceous and hyperkeratotic papules in linear, reticular or plaque form, located on the trunk and limbs for five years. Aphthous lesions in the oral cavity and shallow ulcers on the genitalia also formed part of the clinical manifestation. Pathologic examination was suggestive of keratosis lichenoides chronica. Acitretin and dapsone was introduced and the lesions partially improved. Keywords: Keratosis; Lichenoid eruptions; Skin diseases Resumo: A queratose liquenoide crônica ou doença de Nekam é uma dermatose mucocutânea rara da queratinização, com curso crônico e progressivo, que acomete geralmente indivíduos entre 20 e 40 anos. Existem, aproximadamente, 70 casos descritos na literatura. Devido à raridade desta dermatose e à ausência de tratamento efetivo, é uma doença de difícil manejo. No caso em questão, apresentamos um paciente de 42 anos com pápulas violáceas, hiperqueratósicas, algumas confluentes, com aspecto linear, rendilhado e em placas, localizadas no tronco e membros há cinco anos. Lesões aftoides na cavidade oral e úlceras rasas na genitália também faziam parte do quadro. O anatomopatológico foi bastante sugestivo de queratose liquenoide crônica. Introduziu-se tratamento com acitretina e dapsona, havendo melhora parcial do quadro.

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Response of Keratosis Lichenoides Chronica to Efalizumab Therapy

2009

Arch Dermatol

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Keratosis lichenoides chronica treated with acitretin plus narrowband ultraviolet B phototherapy

Cited by 18 publications

References 12 publications

Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Queratose liquenoide crônica: relato de caso

Response of Keratosis Lichenoides Chronica to Efalizumab Therapy

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