Keratosis lichenoides chronica

Konstantinov, Konstantin N.; Søndergaard, Jørgen; Izuno, G T; Obreshkova, E.

doi:10.1016/s0190-9622(98)70570-5

Cited by 38 publications

(31 citation statements)

References 17 publications

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“…They are arranged in linear or reticular patterns. A concurrent seborrheic dermatitis-like facial eruption is also often present 2, 3. Behcet disease, which is also characterized by mucosal ulceration, typically presents with a papulopustular eruption, helping to differentiate these 2 etiologies 4 .…”

Section: Discussionmentioning

confidence: 99%

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Keratosis lichenoides chronica successfully treated with isotretinoin and methotrexate

Damsky

King

2017

JAAD Case Reports

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Section: Discussionmentioning

confidence: 99%

“…KLC is characterized clinically by hyperkeratotic papules arranged in a distinctive linear and reticular pattern distributed on the trunk and extremities 2 . This eruption can sometimes be associated with oral and genital ulcers and inflammatory ophthalmologic disease 1 …”

Section: Introductionmentioning

confidence: 99%

Keratosis lichenoides chronica successfully treated with isotretinoin and methotrexate

Damsky

King

2017

JAAD Case Reports

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“…In rare cases hoarseness, due to infiltration of the epiglottis, can be observed. 7 The histopathological findings of keratosis lichenoides chronica vary. These typically refer to the presence of lichenoid dermatitis (lymphocytic infiltration in striped bars), associated with numerous necrotic keratinocytes, focal parakeratosis, neutrophils remaining in the corneal layer, irregular acanthosis and corneal plugs.…”

Section: Discussionmentioning

confidence: 99%

Queratose liquenoide crônica: relato de caso

Martins

Horne

Júnior

et al. 2011

An. Bras. Dermatol.

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Keratosis lichenoides chronica or Nekam´s disease is a rare mucocutaneous dermatosis characterized by keratinization. It is chronic and progressive usually affecting individuals aged 20-40 years. Around 70 cases have been reported in the literature. Due to the rarity of this condition and the lack of effective treatment, it is a difficult disease to manage. In the case described below we present a 42-yearold patient with violaceous and hyperkeratotic papules in linear, reticular or plaque form, located on the trunk and limbs for five years. Aphthous lesions in the oral cavity and shallow ulcers on the genitalia also formed part of the clinical manifestation. Pathologic examination was suggestive of keratosis lichenoides chronica. Acitretin and dapsone was introduced and the lesions partially improved. Keywords: Keratosis; Lichenoid eruptions; Skin diseases Resumo: A queratose liquenoide crônica ou doença de Nekam é uma dermatose mucocutânea rara da queratinização, com curso crônico e progressivo, que acomete geralmente indivíduos entre 20 e 40 anos. Existem, aproximadamente, 70 casos descritos na literatura. Devido à raridade desta dermatose e à ausência de tratamento efetivo, é uma doença de difícil manejo. No caso em questão, apresentamos um paciente de 42 anos com pápulas violáceas, hiperqueratósicas, algumas confluentes, com aspecto linear, rendilhado e em placas, localizadas no tronco e membros há cinco anos. Lesões aftoides na cavidade oral e úlceras rasas na genitália também faziam parte do quadro. O anatomopatológico foi bastante sugestivo de queratose liquenoide crônica. Introduziu-se tratamento com acitretina e dapsona, havendo melhora parcial do quadro.

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“…There may be vacuolar alteration of the basal layer along the dermo-epidermal junction (2,5). Although KLC has some common clinical and dermatopathological features with lichen planus, it is considered to be a distinct entity (6). The etiopathogenesis of KLC is still unknown but its close similarity to lichenoid drug eruption induced by tuberculostatic and anti-malarial drugs suggest that KLC is a variant of lichenoid druginduced eruptions (3).…”

Section: Casementioning

confidence: 99%

Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Zindancı¹,

Okur²,

Zemheri³

et al. 2014

Respir Case Rep

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Keratosis lichenoides chronica (KLC) is a rare and chronic skin disease characterized by erythema, keratotic and lichenoid papules are distributed symmetrically. The histological examination of KLC reveals lichenoid dermatitis with hyper and parakeratosis. Although the etiology and pathogenesis of KLC are unknown, it is suggested that KLC is a variant of lichen planus or lichenoid drug eruptions. We present a case of generalized KLC that occurred during antituberculosis therapy including isoniazid, rifampicin, ethambutol, and pyrazinamide and dramatically improved after cessation of therapy. We report this generalized KLC case in order to draw attention to the side effects that can be seen during tuberculosis treatment.

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Keratosis lichenoides chronica

Cited by 38 publications

References 17 publications

Keratosis lichenoides chronica successfully treated with isotretinoin and methotrexate

Keratosis lichenoides chronica successfully treated with isotretinoin and methotrexate

Queratose liquenoide crônica: relato de caso

Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

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