PENICILLIN IN THE TREATMENT OF INFECTED HANDS MEDBCRATS ORNA605well as in man-hours. Even better results would be obtainable if patients could be seen in the earlier stages of infection. Of the cases detailed in Table I, 65% needed immediate incision; in the three cases in Table II The penicillin-treated series comprised 7 cases of paronychia and pulp-space infection, with an average loss of 9.9 days' duty; 6 cases of tenosynovitis, with an average loss of 9.9 days (excluding Case 13, 7.4 days); and 4 cases of palmar-space infection, with an average loss of 17 days (excluding Case 16, 9.3 days). The average loss of duty in these 17 cases was 10.9 days. If the two unusual cases, Nos. 13 and 16, are excluded, the final average is reduced to 8.9 days-a saving of 56% compared with the non-penicillin series.On the basis of these results it is suggested that the administration of penicillin in all severe infections of the hand, both in the early stages and after any necessary surgical intervention, should be adopted as a routine method of treatment.In practice a dosage of 125,000 units in oil or 300,000 units in aqueous solution twice daily has been found adequate.We are indebted to Mr. G. T. Mullally, Senior Surgeon, Westminster Hospital, whose enthusiasm and interest made this experiment possible; to Prof. R. J. V. Pulvertaft, who made penicillin in beeswax-oil available at a time when supplies were limited; and to the nursing staff of the surgery for their co-operation in carrying out treatment.