Keratocystic odontogenic tumor: systematic review with analysis of 72 additional cases from Mumbai, India

Sansare, Kaustubh; Raghav, Mamta; Mupparapu, Mel; Mundada, Nilesh; Karjodkar, Freny; Bansal, Shivani; Desai, Rajiv S.

doi:10.1016/j.oooo.2012.10.005

Cited by 28 publications

(14 citation statements)

References 49 publications

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“…[89] Other clinical presentations of KCOT in this study are seen frequently in the third decade of life (mean age 30 years) and at posterior mandibular region, which is again similar to most others studies. [710111213] OOC, on the other hand, show male predominance with a male: female ratio of 2.7:1, consistent with other study result,[14] with mean age of diagnosis being 29.1 years. It occurs more frequently in mandible, that too in the molar-ramus region, similar to the findings of Dong et al .…”

Section: Discussionsupporting

confidence: 90%

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Prevalence and clinicopathological comparison of kerotocystic odontogenic tumor and orthokeratinized odontogenic cyst in South Indian sample population: A retrospective study over 13 years

et al. 2014

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Aim and Methodology:The purpose of this study is to determine the prevalence of keratocystic odontogenic tumor (KCOT) and orthokeratinized odontogenic cyst (OOC), to identify their clinicopathological features among the patients by studying the biopsy specimens obtained from the archives of the Department of Oral and Maxillofacial Pathology, College of Dental Sciences, Davangere, Karnataka, India during the period of 2001-2013. Data for this study is retrieved from the case records of the patients fitting the histological classification of the World Health Organization (2005). The following clinical variables, namely age, gender, anatomical location, and histological features are analyzed.Results:Of the 3026 biopsy reports (100%) present in the archives, we had 31 cases (1.02%) of KCOT, 11 cases (0.36%) of OOC and a combination of para and orthokeratinized lining epithelium made 1 case (0.033%). The most frequent clinical manifestation was asymptomatic followed by the combination of pain and swelling. The male: female ratio was 1.4:1 with a mean age of 30 years in KCOT, while 2.7:1 with a mean age of 29.1 years in OOC. Posterior molar-ramus region was most commonly involved in both KCOT and OOC.Conclusion:Due to aggressiveness and high recurrence rate of KCOT, differentiation between KCOT and OOC is important, with respect to their treatment modalities. Such epidemiological pools are also essential for the analysis of geographical distribution of odontogenic tumours

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Section: Discussionsupporting

confidence: 90%

“…Prevalence of KCOT (1.02%) is more than OOC (0.36%) similar to the findings of another study from Indian population,[7] but prevalence rate varies between the two studies, which may be due to the discrepancy in sample size.…”

Section: Discussionsupporting

confidence: 83%

Prevalence and clinicopathological comparison of kerotocystic odontogenic tumor and orthokeratinized odontogenic cyst in South Indian sample population: A retrospective study over 13 years

et al. 2014

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“…The slightly higher mean age (20.1 years) seen in the present study for odontomas probably reveals the fact that Brazilian patients do not frequently undergo routine panoramic X-ray and so odontomas are not diagnosed as early. A systematic review of KCOT revealed a mean age of 36.5 years with a peak of incidence in the second and third decades of life (30). Our mean age were similar (36.6 years), but with a smoother distribution over the decades.…”

Section: Discussionmentioning

confidence: 99%

The relative frequency of odontogenic tumors: A study of 376 cases in a Brazilian population

Lima-Verde-Osterne

Turatti²,

Cordeiro-Teixeira³

et al. 2017

Med Oral

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BackgroundOdontogenic tumors (OTs) are rare lesions, exclusive of the jaws, that are derived from epithelial and/or ectomesenchymal elements of the tooth-forming apparatus. Their biological behavior is heterogeneous, including hamartomatous tissue proliferation, benign nonaggressive and aggressive neoplasms, and malignant tumors with metastatic capacity. The aim of this study was to describe the relative frequency of odontogenic tumors in a Brazilian population. In addition, a review of the literature identified studies on odontogenic tumors that follow the 2005 World Health Organization.Material and MethodsA total of 376 cases of odontogenic tumors from an oral pathology service were reviewed about age, gender, anatomic site and histologic diagnosis.ResultsKeratocystic odontogenic tumors (31.6%) were the most common, followed by ameloblastoma (28.5%), and odontoma (22.6%). The mean age was 32.2 years, and more than half the patients (52.1%) were in the second and third decades of life. The male to female ratio was 1:1.37, with a maxilla to mandible ratio of 1:2.08.ConclusionsThe variation in relative frequency of tumors observed among the several series, including the present study, is probably due in part to cultural differences between geographic areas but also to the study design. Key words:Pathology, epidemiology, odontogenic tumors.

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“…KCOTs comprise approximately 11% of all cysts of the jaws [7]. They occur most commonly in the mandible, especially in the posterior body and ramus regions [1,2,7]. It may be solitary or multiple and the latter is usually characterizing the inherited nevoid basal cell carcinoma syndrome “NBCCS”.…”

Section: Introductionmentioning

confidence: 99%

Endoplasmic Reticulum Stress-Associated Chaperones, Bip/GRP78 and Calnexin are Overexpressed in Keratocystic Odontogenic Tumours

Pavli

Farmaki

Merkourea

et al. 2014

JOMR

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Objectives Odontogenic keratocysts (OKCs) are developmental cysts that have been reclassified according World Health Organization (WHO), to keratocystic odontogenic tumours (KCOTs), a term that better reflects their neoplastic nature. The aim of present study is to evaluate the induction of stress of the endoplasmic reticulum and execution of the resulting unfolded protein response in keratinocystic odontogenic tumours.Material and MethodsWe analyzed by immunohistochemistry the expression of the chaperones BiP/GRP78 and calnexin in 24 cases of KCOTs. As controls, we have used 9 cases of periapical or radicular cysts (PACs) and 5 cases of Fibromas (FBs). The PACs and the FBs were included in the analysis, as PACs are the most common type of inflammatory odontogenic cysts of and FBs, as lesions of the connective tissue with unaffected epithelium.ResultsAnalysis revealed a strong association between both BiP/GRP78 and calnexin expression and KCOTs: 18 out of 24 (75%) KCOTs expressed BiP/GRP78 as opposed to 1 out of 9 (13%) PACs, and none of 5 FBs evaluated (P < 0.001, x2-test). Calnexin was expressed in 11 out of 24 KCOTs (46%) but only one out of 9 (13%) PACs, and none of the 5 FBs analyzed (P < 0.001, x2-test).ConclusionsStudy results imply that induction of endoplasmic reticulum stress maybe of diagnostic value in keratocystic odontogenic tumours characterization. In addition to recent findings suggesting that endoplasmic reticulum stress plays a causative role in keratinization of epithelia, pharmacological interference with the execution of the unfolded protein response should be considered for the management of keratocystic odontogenic tumours.

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Keratocystic odontogenic tumor: systematic review with analysis of 72 additional cases from Mumbai, India

Cited by 28 publications

References 49 publications

Prevalence and clinicopathological comparison of kerotocystic odontogenic tumor and orthokeratinized odontogenic cyst in South Indian sample population: A retrospective study over 13 years

Prevalence and clinicopathological comparison of kerotocystic odontogenic tumor and orthokeratinized odontogenic cyst in South Indian sample population: A retrospective study over 13 years

The relative frequency of odontogenic tumors: A study of 376 cases in a Brazilian population

Endoplasmic Reticulum Stress-Associated Chaperones, Bip/GRP78 and Calnexin are Overexpressed in Keratocystic Odontogenic Tumours

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