Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa

Lima, Ádila Lorena Morais; Karl, Ingolf; Giner, Tina; Poppe, H; Schmidt, Marc; Presser, Dagmar; Goebeler, Matthias; Bauer, Boris

doi:10.1111/bjd.14214

Cited by 188 publications

(235 citation statements)

References 26 publications

(45 reference statements)

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“…We do not know the extent of their influence in the pathology of psoriasis or in comparison with other IL-17/IL-22 producing cell types but recent publications addressing the dermato-pathology in skin diseases such as hydradenitis suppurativa, Schnitzler’s syndrome and delayed-pressure urticaria suggest a broader role of neutrophil-produced IL-17 in skin inflammation 16,17 . Another aspect of IL-17 production by neutrophils in psoriatic inflammation is that neutrophils, comprising more than 50% of leukocytes in the blood and might contribute to the cardio metabolic co morbidities associated with severe psoriasis.…”

Section: To the Editormentioning

confidence: 99%

Interleukin (IL)-17A and IL-22-producing neutrophils in psoriatic skin

et al. 2017

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Section: To the Editormentioning

confidence: 99%

Interleukin (IL)-17A and IL-22-producing neutrophils in psoriatic skin

et al. 2017

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“…A greater caspase-1 activity in the keratinocytes of the affected skin was also observed. 88 One therapy with colchicine, an effective medication in other diseases with inflammasomes, such as familial mediterranean fever and gout, was evaluated in eight patients with HS, but it proved not to be beneficial. 89 …”

Section: Dermatological Diseases Associated With Inflammasomesmentioning

confidence: 99%

Inflammasomes and dermatology

Sá

Neto

2016

An. Bras. Dermatol.

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Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the absence of autoantigens and autoantibodies. Skin symptoms include the main features of monogenic inflammasomopathies, such as Cryopyrin-Associated Periodic Syndromes (CAPS), Familial Mediterranean Fever (FMF), Schnitzler Syndrome, Hyper-IgD Syndrome (HIDS), PAPA Syndrome, and Deficiency of IL-1 Receptor Antagonist (DIRA). Concepts from other pathologies have also been reviewed in recent years, such as psoriasis, after the recognition of a combined contribution of innate and adaptive immunity in its pathogenesis. Inflammasomes are also involved in the response to various infections, malignancies, such as melanoma, autoimmune diseases, including vitiligo and lupus erythematosus, atopic and contact dermatitis, acne, hidradenitis suppurativa, among others. Inhibition of the inflammasome pathway may be a target for future therapies, as already occurs in the handling of CAPS, through the introduction of IL-1 inhibitors. This study presents a literature review focusing on the participation of inflammasomes in skin diseases.

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Section: Discussionmentioning

confidence: 99%

“…It has been shown that interleukin-17 (+) cells are increased in lesional and perilesional skin of HS 10 11. These innate immune cells are involved in the inflammatory process of HS 10 11. The large number of infiltrating neutrophils, particularly during the advanced stages of disease, explains how HS can be included in the spectrum of neutrophilic dermatoses 11.…”

Section: Discussionmentioning

confidence: 99%

Hidradenitis suppurativa, neutrophilic dermatoses and diverticular disease in a young African-American patient

Darji

Dhandha

Guo³

2017

BMJ Case Reports

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Hidradenitis suppurativa (HS) is a chronic skin disorder of the terminal follicular epithelium of apocrine sweat glands, manifesting as painful and exudative papules, pustules, cysts or nodules. This inflammatory condition often presents with other systemic and cutaneous disorders. We present the case of an African-American man with HS who was also diagnosed with neutrophilic dermatoses and diverticular disease. Neutrophilic dermatosis was identified based on histopathology findings. Our patient underwent multiple surgeries for flaring of his skin condition. Colchicine and doxycycline were started, but the patient was not able to tolerate them. Humira was planned for treatment of HS and neutrophilic dermatosis but could not be pursued because of the pericolic abscess. Colonoscopy and radiological investigation revealed multiple colonic diverticuli, for which he initially underwent percutaneous drainage followed by surgical removal of sigmoid mass and colocutaneous fistula. Culture from the specimen revealed abnormal growth of .

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Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa

Cited by 188 publications

References 26 publications

Interleukin (IL)-17A and IL-22-producing neutrophils in psoriatic skin

Interleukin (IL)-17A and IL-22-producing neutrophils in psoriatic skin

Inflammasomes and dermatology

Hidradenitis suppurativa, neutrophilic dermatoses and diverticular disease in a young African-American patient

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