Keratinizing dermatoses. Combined data from four centers on short-term topical treatment with tretinoin

Abstract

In four medical centers, 40 patients with keratinizing dermatoses were treated with topical tretinoin (vitamin A acid) 0.1% cream and salicylic acid 2% cream in a short-term, double-blind study. Tretinoin was the more effective treatment for several of the keratinizing dermatoses with the exception of palmar-plantar hyperkeratosis, for which it was not effective in the concentration and method of application used. The most striking clinical responses occurred in patients with lamellar ichthyosis and ichthyosis vulgaris. Local adverse reactions-chiefly pruritus, erythema, burning, excoriation, and irritation-were not severe and could be controlled by modification of the treatment regimen.

X-linked ichthyosis: An oculocutaneous genodermatosis

“…A short-term paired comparison on two patients with XLI suggested 0.1% tretinoin cream was superior to 0.1% topical tretinoin cream. 59 Hofmann et al 60 recently demonstrated superior efficacy of the receptor-selective retinoid tazarotene at 0.05% concentration in the treatment of 4 patients with XLI. Systemic absorption of this agent when used topically for ichthyoses has since been shown to be minimal.…”

Perspective and Consensus Opinion: Good Practices for Using Organotypic Skin and Epidermal Equivalents in Experimental Dermatology Research

“…and reversing ectropion in congenital ichthyosis. 9,10,18,20,21,24,[48][49][50][51] Most case reports have focused on lamellar ichthyosis, although improvement also has been reported for other forms of ichthyosis, including other autosomal recessive congenital ichthyoses, recessive X-linked ichthyosis, 52 epidermolytic ichthyosis, 53,54 and erythrokeratodermia variabilis. 55 There are more reports on the effective use of tazarotene than other topical retinoids, but no direct comparisons have been performed.…”

“…Cutaneous adverse effects include erythema, pruritus, irritation, and photosensitivity. 49 There is likely an increased risk for these adverse effects in ichthyosis vulgaris, patients with associated atopic dermatitis, and others with skin fragility. 49 No systemic adverse effects have been reported with widespread use.…”

“…49 There is likely an increased risk for these adverse effects in ichthyosis vulgaris, patients with associated atopic dermatitis, and others with skin fragility. 49 No systemic adverse effects have been reported with widespread use. 56 With widespread use of tazarotene, some patients have had measurable but low plasma drug levels; thus, it is designated pregnancy category X and pregnancy should be avoided with tazarotene use.…”

Effect of Vitamin A Acid on Homeostasis and Differentiation of Epidermal Cells Cultured on Collagen

“…On the other hand, they influ ence cell differentiation and they are also ef fective in non-proliferating hyperkeratotic conditions, e.g. ichthyosis vulgaris and xlinked ichthyosis [7,9,15].…”