Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans

Porter, Rebecca; Corden, Laura D.; Lunny, Declan P.; Smith, Frances J.D.; Lane, E.B.; McLean, W.H. Irwin

doi:10.1046/j.1365-2133.2001.04463.x

Cited by 35 publications

(44 citation statements)

References 36 publications

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“…Type I and type II keratin proteins that are specifically expressed in the IRS of murine hair follicles have been described [37–39]. We used two antibodies that are specific for the IRS type I keratins mIRSa3.1 and mIRSa2 [37] to visualize the IRS cells; these proteins are expressed in all three cell layers of the IRS.…”

Section: Resultsmentioning

confidence: 99%

Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

Wang¹,

Arantes²,

Conti³

et al. 2007

Molecular Carcinogenesis

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ATF3 is a highly conserved eukaryotic transcription factor that is ubiquitously upregulated transcriptionally during cellular responses to a variety of stresses, in particular DNA damage. However, the role of ATF3 in the DNA damage response is unclear. Transgenic mice that overexpress human ATF3 in basal epithelial cells under the control of the bovine keratin 5 (K5) promoter were constructed and characterized for epidermal alterations. Strong, nuclear expression of the exogenous ATF3 protein was seen in basal cells of the epidermis, hair follicles, and oral mucosa. Hyperplastic changes in the K5-expressing, outer root sheath (ORS) cells of the hair follicle were observed in young mice, resulting in multiple layers of ORS cells in the mature follicle and large aberrantly shaped follicles. Mild hyperplasia of the interfollicular epidermis was also noted, increasing with age. However, no epidermal tumors were identified in BK5.ATF3 mice observed for 16 mo. At 16 mo of age, most transgenic mice exhibited multi-focal areas of hyperplasia and dysplasia in the oral mucosa, with cellular atypia and underlying acute inflammatory changes. Neoplastic lesions were also seen in the oral cavity of BK5.ATF3 mice, including oral squamous cell carcinoma (60% incidence) and basal cell tumors with follicular differentiation (70% incidence), but not in non-transgenic FVB/N littermates. Heterogeneous nuclear expression (or stabilization) of p53 protein was seen in some oral dysplasias, with a patchy distribution primarily in the least differentiated layers of the lesions. This represents the first indication that ATF3 may have oncogenic properties in epithelial cells.

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Section: Resultsmentioning

confidence: 99%

Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

Wang¹,

Arantes²,

Conti³

et al. 2007

Molecular Carcinogenesis

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show abstract

“…Another possible candidate may be the gene encoding for the new keratin ( K6IRS ) specific for the IRS. [13] This faulty keratinization leads to impaired adherence of the ORS–IRS, resulting in premature cessation of the anagen phase and account for reduced hair length. The findings of Chapalain indicate that the ORS–IRS adhesion is involved in at least some cases.…”

Section: Historymentioning

confidence: 99%

Loose anagen hair syndrome

Dhurat

Deshpande

2010

Int J Trichol

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Loose anagen syndrome (LAS) is a benign, self-limiting condition where anagen hairs are easily and painlessly extracted. It is mainly reported in childhood; however, it may variably present in adulthood as well. The presence of anagen hair devoid of its sheath and with ‘floppy sock appearance’ is a characteristic feature of loose anagen hair (LAH) on trichogram. LAH can be seen in normal population and in alopecia areata. The percentage of LAH in LAS is more than 50%. The histopathological findings show clefting between the layers of hair and are very useful in differentiating LAS from alopecia areata. Here, a review on the diagnostic criteria and practical guidelines are discussed so as to enable the trichologist in managing this benign, self-limiting condition and differentiating it from the other causes of non-scarring alopecias.

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“…Another possible candidate may be the gene encoding for the new keratin (K6IRS) specific for the inner root sheath. 10 …”

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confidence: 99%

Loose Anagen Hair Syndrome and Loose Anagen Hair

Tosti¹,

Piraccini²

2002

Arch Dermatol

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Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans

Abstract: This new keratin, designated K6irs, is a valuable histological marker for the inner root sheath of hair follicles in mice and humans. In addition, this keratin represents a new candidate gene for inherited structural hair defects such as loose anagen syndrome.

Cited by 35 publications

References 36 publications

Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

Loose anagen hair syndrome

Loose Anagen Hair Syndrome and Loose Anagen Hair

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