Loose Anagen Hair Syndrome and Loose Anagen Hair

Tosti, Antonella; Piraccini, Bianca Maria

doi:10.1001/archderm.138.4.521

Cited by 54 publications

(73 citation statements)

References 8 publications

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“…[1][2][3][4][5][6][7][8] In accordance with previous studies, 1,3,8,10-12 a large subset of patients had hair with an odd texture or hair that was difficult to comb, frizzy, or unruly. This texture difference is usually described as "sticky" or "matted" and is commonly located on the occipital scalp.…”

Section: Commentsupporting

confidence: 73%

Practical Guidelines for Evaluation of Loose Anagen Hair Syndrome

Cantatore-Francis¹,

Orlow²

2009

Arch Dermatol

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Section: Commentsupporting

confidence: 73%

Practical Guidelines for Evaluation of Loose Anagen Hair Syndrome

Cantatore-Francis¹,

Orlow²

2009

Arch Dermatol

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“…Loose anagen hair has been observed in an isolated loose anagen hair syndrome (OMIM 600628) 24 and has been found to be associated with Noonan syndrome. 25,26 The pathogenesis of loose anagen hair remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Abnormalities in the keratin gene have been suggested. 24 Functional analysis of the SHOC2 p.S2G mutant showed that the mutant protein was aberrantly localized in the membrane fraction after stimulation with epidermal growth factor and induced extracellular signal-regulated kinase signaling in a cellspecific manner. 18 It is possible that dysregulated proliferation or cell-to-cell attachment causes the detachment between inner sheaths and hair shafts.…”

Section: Discussionmentioning

confidence: 99%

Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies

et al. 2010

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Noonan syndrome is an autosomal dominant disease characterized by dysmorphic features, webbed neck, cardiac anomalies, short stature and cryptorchidism. It shows phenotypic overlap with Costello syndrome and cardio-facio-cutaneous (CFC) syndrome. Noonan syndrome and related disorders are caused by germline mutations in genes encoding molecules in the RAS/MAPK pathway. Recently, a gain-of-function mutation in SHOC2, p.S2G, has been identified as causative for a type of Noonan-like syndrome characterized by the presence of loose anagen hair. In order to understand the contribution of SHOC2 mutations to the clinical manifestations of Noonan syndrome and related disorders, we analyzed SHOC2 in 92 patients with Noonan syndrome and related disorders who did not exhibit PTPN11, KRAS, HRAS, BRAF, MAP2K1/2, SOS1 or RAF1 mutations. We found the previously identified p.S2G mutation in eight of our patients. We developed a rapid detection system to identify the p.S2G mutation using melting curve analysis, which will be a useful tool to screen for the apparently common mutation. All the patients with the p.S2G mutation showed short stature, sparse hair and atopic skin. Six of the mutationpositive patients showed severe mental retardation and easily pluckable hair, and one showed leukocytosis. No SHOC2 mutations were identified in leukemia cells from 82 leukemia patients. These results suggest that clinical manifestations in SHOC2 mutation-positive patients partially overlap with those in patients with typical Noonan or CFC syndrome and show that easily pluckable/loose anagen hair is distinctive in SHOC2 mutation-positive patients.

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“…Usually the hair color is blonde but in the recent years LAHS in brown and black hairs was described. 1 Clinical presentation is heterogeneous. Three primary LAHS phenotypes have been described based mainly on the clinical signs of reduced hair, hair length, increased hair shedding and altered hair texture: type A, with sparse hair that does not grow long; type B, characterized by diffuse or patchy, unruly hair; and type C, characterized by normalappearing hair with excessive shedding of loose anagen hairs and predominantly affects adults.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore revised criteria were suggested, which indicate that the diagnosis of LAHS should be established when the trichogram shows at least 70% loose anagen hairs. 1 Cantatore-Francis and Orlow proposed that LAHS should be diagnosed only when there are more than 50% loose anagen hairs in the trichogram. 10 Trichoscopy (hair and scalp dermoscopy) is a rapid in-office technique, which has become a standard procedure in differential diagnosis of hair loss.…”

Section: Introductionmentioning

confidence: 99%

Trichoscopy findings in loose anagen hair syndrome: rectangular granular structures and solitary yellow dots

Rakowska¹,

Zadurska²,

Czuwara³

et al. 2015

J Dermatol Case Rep

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Background: Loose anagen hair syndrome (LAHS) is typically diagnosed in girls older than 2 years who present with hair that "will not grow". Hair microscopic examination shows absent inner and outer root sheaths, ruffling of the cuticle on the proximal hair shaft and deformed pigmented anagen bulbs.Objective: The aim of the study was to assess whether there are characteristic trichoscopic features favoring the diagnosis of LAHS. Patients and methods:Eighty nine children patients were included into the study (24 girls with LAHS, 25 with alopecia areata, 20 with telogen effluvium and 20 healthy children). In all groups trichoscopy was performed. Trichoscopy images were analyzed for abnormalities in the hairs shafts, the hair follicle openings and the interfollicular area.Results: Dirty dots were present in all groups. A unique feature of LAHS was the presence of rectangular black granular structures which differs from dense black dots seen in patients with alopecia areata. This feature was observed in 71% of patients with LAHS. Follicular units with single hairs constituted 92,9% of hair units in these patients (65,5% in telogen effluvium and 53% in the control group). Solitary yellow dots were found in 50% of patient with LAHS and in 24% of patients with alopecia areata, but was not found in control group or in patients with telogen effluvium. Conclusion:The trichoscopy features favoring the diagnosis of LAHS are: rectangular black granular structures, solitary yellow dots and major predominance of follicular units with single hairs. (J Dermatol Case Rep. 2015; 9(1): 1-5)

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Loose Anagen Hair Syndrome and Loose Anagen Hair

Cited by 54 publications

References 8 publications

Practical Guidelines for Evaluation of Loose Anagen Hair Syndrome

Practical Guidelines for Evaluation of Loose Anagen Hair Syndrome

Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies

Trichoscopy findings in loose anagen hair syndrome: rectangular granular structures and solitary yellow dots

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