Keloids Treated with Topical Injections of Triamcinolone Acetonide (Kenalog): Immediate and Long-term Results

Kiil, J

doi:10.3109/02844317709025514

Cited by 123 publications

(67 citation statements)

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“…Overall, this modality has a high degree of tolerability as well as effectiveness in reducing symptoms. Several studies evaluating intralesional steroids have reported roughly a 50% recurrence rate [2,3]. In the recent past, intralesional 5-FU has been tried in hypertrophic scars and keloids in combination or as an individual therapeutic agent [1,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…A paucity of literature is available regarding the usefulness and safety profile of 5-FU as an individual therapeutic agent [1]. However, several studies suggest that the overall efficacy is not better than other modalities and significant side effects such as ulceration and hyperpigmentation make topical 5-FU less appealing [1][2][3][4][5]. Hence, we conducted a prospective trial to compare the efficacy of 5-FU versus triamcinolone as a therapeutic agent for the treatment of keloids.…”

Section: Introductionmentioning

confidence: 99%

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A Comparative Clinical Study on Role of 5-Flurouracil Versus Triamcinolone in the Treatment of Keloids

Saha

Mukhopadhyay

2012

Indian J Surg

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A wide range of therapies exist for keloids. But despite the multiple treatment modalities available, keloids still remain a significant challenge for both the clinician and the patient. To compare the efficacy of 5-flurouracil (5-FU) versus triamcinolone as a therapeutic agent for the treatment of keloids. A randomized control trial was carried out at a teaching hospital in Kolkata over a period 2.5 years. Fortyfour patients took part in the study, 20 in group F and 24 in group T. The age ranged from 16 to 66 years. The mean age of group F was 34.7±11.0124 years (range 16-66 years) and of group T was 32.96±9.584 years (range 19-60 years). The difference in the age and sex between the two groups was comparable and not statistically significant (p00.096). The response was rated as excellent (76-100% decrease in volume), good (51-75%), fair (26-50%), and poor (less than 25%). The reduction in keloid volume was comparable in both the groups. But side effects were much more in group F compared to group T. About 95% of the patients in group F found the injection very painful. About 6% of the patients in group F presented soon after the first two to three sessions with superficial ulcerations at the injection site accompanied by mild discomfort and discharge. This side effect was not seen in group T. Regarding pain at the injection site and superficial ulceration, the difference between the two groups was found to be statistically significant (p<0.05). The patients treated with 5-FU experienced side effects such as hyperpigmentation, pain at the injection site, and superficial ulceration, which were statistically highly significant. It appears from this study that triamcinolone is a better tolerated and less toxic alternative to 5-FU in the management of keloids.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comparative Clinical Study on Role of 5-Flurouracil Versus Triamcinolone in the Treatment of Keloids

Saha

Mukhopadhyay

2012

Indian J Surg

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“…12,13 In the majority of patients, multiple intralesional injections are needed to obtain the desired clinical effect, i.e. flattening of the lesion and cessation of itching.…”

Section: J B Van Rijswijk E a M Mylanusmentioning

confidence: 99%

“…12 The main effect of intralesional steroids on the connective tissue of keloids is a decrease in viscosity due to a loss of ground substance. 14 Few complications have been documented, and are limited to local skin changes or pain as a result of the injection.…”

Section: J B Van Rijswijk E a M Mylanusmentioning

confidence: 99%

Intralesional triamcinolone acetonide injection in hypertrophic skin surrounding the percutaneous titanium implant of a bone-anchored hearing aid

Rijswijk

Mylanus

2008

J. Laryngol. Otol.

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Intralesional triamcinolone acetonide injection in hypertrophic skin surrounding the percutaneous titanium implant of a bone-anchored hearing aid van Intralesional triamcinolone acetonide injection in hypertrophic skin surrounding the percutaneous titanium implant of a bone-anchored hearing aid AbstractObjective:We present a patient with persistent hypertrophic skin surrounding the percutaneous implant of a bone-anchored hearing aid system, successfully treated with intralesional applied corticosteroids.Method:Case report and review of the world literature concerning bone-anchored hearing aid implantation and intralesional applied corticosteroids for the treatment of hypertrophic scars and keloids.Results:Eight weeks after revision surgery to reduce surplus skin and subcutaneous scar tissue overgrowing the abutment, skin and subcutaneous scar tissue overgrowth reoccurred. As an alternative to yet another surgical procedure, the hypertrophic skin was treated with intralesional injections of triamcinolone acetonide. Three weeks after the treatment, a satisfying result was seen, and no subsequent relapse was observed.Conclusion:To our knowledge, this is the first, photographically well documented case report of a patient with persistent hypertrophic skin surrounding a percutaneous bone-anchored hearing aid implant, successfully treated with intralesional applied corticosteroids. Clinical RecordIntralesional triamcinolone acetonide injection in hypertrophic skin surrounding the percutaneous titanium implant of a bone-anchored hearing aid J B VAN RIJSWIJK, E A M MYLANUS* AbstractObjective: We present a patient with persistent hypertrophic skin surrounding the percutaneous implant of a bone-anchored hearing aid system, successfully treated with intralesional applied corticosteroids. Method: Case report and review of the world literature concerning bone-anchored hearing aid implantation and intralesional applied corticosteroids for the treatment of hypertrophic scars and keloids.Results: Eight weeks after revision surgery to reduce surplus skin and subcutaneous scar tissue overgrowing the abutment, skin and subcutaneous scar tissue overgrowth reoccurred. As an alternative to yet another surgical procedure, the hypertrophic skin was treated with intralesional injections of triamcinolone acetonide. Three weeks after the treatment, a satisfying result was seen, and no subsequent relapse was observed.Conclusion: To our knowledge, this is the first, photographically well documented case report of a patient with persistent hypertrophic skin surrounding a percutaneous bone-anchored hearing aid implant, successfully treated with intralesional applied corticosteroids.

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“…As early as in the 1960s, authors reported curative results in up to 80% of the cases [9][10][11][12]. Other, more recent studies suggest recurrence rates between 9% and 50% with this line of treatment [13][14][15][16][17]. Alternative treatment options include surgery followed by radiotherapy, and other injectable substances, such as 5-fluorouracil, bleomycin and verapamil [18].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Results of Intralesional Triamcinolone Acetonide Injections in Keloid Treatment

Hietanen¹,

Välisuo²

2016

J Clin Trials

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Keloids Treated with Topical Injections of Triamcinolone Acetonide (Kenalog): Immediate and Long-term Results

Cited by 123 publications

References 4 publications

A Comparative Clinical Study on Role of 5-Flurouracil Versus Triamcinolone in the Treatment of Keloids

A Comparative Clinical Study on Role of 5-Flurouracil Versus Triamcinolone in the Treatment of Keloids

Intralesional triamcinolone acetonide injection in hypertrophic skin surrounding the percutaneous titanium implant of a bone-anchored hearing aid

Long-Term Results of Intralesional Triamcinolone Acetonide Injections in Keloid Treatment

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