Keloids in rural black South Africans Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients

Louw, Louise; Dannhauser, A

doi:10.1054/plef.2000.0208

Cited by 25 publications

(26 citation statements)

References 40 publications

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“…Based on nutritional deficiencies in FAs, identified in keloids and in keloid patients (Louw et al, 1997a,b;Louw and Dannhauser, 2000;Louw, 2000b), an immunonutritional approach with FAs (Louw, 2003) and phytochemical dietary compounds (Phan et al, 2003a) for keloid management has emerged. Modulation of human immune and inflammatory responses by dietary FAs is now commonly known (Kelley, 2001;Yaqoob, 2004).…”

Section: Immunonutritional Disordermentioning

confidence: 99%

“…Despite sufficient dietary FA intake and metabolism in keloid patients (Louw and Dannhauser, 2000), and sufficient FA circulation via microvasculature to fibroblasts and wound healing cells in the interface and peripheral keloid areas, prolonged inflammatory and cytokine mediated reactions are believed to be responsible for continuous depletion of membrane antiinflammatory FA sources and likely deregulation of signaling pathways (Louw et al, 1997a,b). In the central areas of the keloids, deprivation of FA sources through microvessel occlusion contributes to FA deficient fibroblasts compared with those in the peripheral areas (Louw et al, 1997b), decreased fibroblast proliferation, and hypoxic conditions under which fibroblasts express a greater number of binding sites for TGF-b (Kischer, 1992;Bettinger et al, 1996;Appleton et al, 1996).…”

Section: Angiogenesis and Hypoxiamentioning

confidence: 99%

“…From the constructed ex vivo keloid lipid model (Louw, 2000a,b;Louw and Dannhauser, 2000), FA strategies for keloid prevention predicated on reducing fibroblast membrane concentrations of proinflammatory LA and AA in the wound area after keloid excision, and treatments that enhance anti-inflammatory precursors and competitors of AA in keloid formations, need to be tested.…”

Section: Proposed Fatty Acid Strategiesmentioning

confidence: 99%

“…A proper diet for the keloid-susceptible patient must also contain important micronutrients (such as iron, zinc, vitamins, magnesium, copper and calcium), since they may influence FA metabolism or collagen synthesis (Louw and Dannhauser, 2000).…”

Section: Proposed Fatty Acid Strategiesmentioning

confidence: 99%

See 3 more Smart Citations

The keloid phenomenon: Progress toward a solution

Louw

2006

Clinical Anatomy

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For centuries, keloids have been an enigma and despite considerable research to unravel this phenomenon no universally accepted treatment protocol currently exists. Historically, the etiology of keloids has been hypothesized by multiple different theories; however, a more contemporary view postulates a multifactoral basis for this disorder involving nutritional, biochemical, immunological, and genetic factors that play a role in this abnormal wound healing. Critical to the process of preventing or managing keloids is the need to locally control fibroblasts and their activities at the wound site. In recent years, considerable evidence has accumulated demonstrating the importance of fatty acids and bioactive lipids in health and disease, especially those involving inflammatory disorders or immune dysfunction. If hypertrophic scarring and keloid formation can be argued to have significant inflammatory histories, then it is possible to postulate a role for lipids in their etiology and potentially in their treatment. This report briefly visits past views and theories on keloid formation and treatment, and offers a theoretical rationale for considering adjuvant fatty acid therapy for keloid management. Sufficient scientific evidence in support of fatty acid strategies for the prevention and treatment of keloids currently exists, which offer opportunities to bridge the gap between the laboratory and the clinic. The intent of this paper is to serve as a basic guideline for researchers, nutritionists, and clinicians interested in keloids and to propose new directions for keloid management.

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Section: Immunonutritional Disordermentioning

confidence: 99%

Section: Angiogenesis and Hypoxiamentioning

confidence: 99%

Section: Proposed Fatty Acid Strategiesmentioning

confidence: 99%

Section: Proposed Fatty Acid Strategiesmentioning

confidence: 99%

See 2 more Smart Citations

The keloid phenomenon: Progress toward a solution

Louw

2006

Clinical Anatomy

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“…This may reflect changes in the mechanisms that cause these esters to accumulate in the skin, namely their transfer from the dermis, adipose tissue and serum, their synthesis in the epidermis, and their modification by bacterial enzymes [11,12]. In relation to this, patients with keloids have been found to consume higher levels of dietary linoleic acid (LA) and arachidonic acid (AA) than recommended (7–11 g/d), and they also consume α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) at levels below the recommended 1.1–1.5 g/d [9]. Moreover, keloids bear higher levels of AA than the skin of keloid-prone and non-keloid-prone patients [10].…”

Section: Introductionmentioning

confidence: 99%

Roles of lipid metabolism in keloid development

Huang

Ogawa

2013

Lipids Health Dis

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Keloids are common cutaneous pathological scars that are characterised by the histological accumulation of fibroblasts, collagen fibres, and clinically significant invasive growth. Although increasing lines of research on keloids have revealed genetic and environmental factors that contribute to their formation, the etiology of these scars remains unclear. Several studies have suggested the involvement of lipid metabolism, from a nutritional point of view. However, the role that lipid metabolism plays in the pathogenesis and progression of keloids has not previously been reviewed. The progress that has been made in understanding the roles of the pro- and anti-inflammatory lipid mediators in inflammation, and how they relate to the formation and progression of keloids, is also outlined. In particular, the possible relationships between mechanotransduction and lipid metabolites in keloids are explored. Mechanotransduction is the process by which physical forces are converted into biochemical signals that are then integrated into cellular responses. It is possible that lipid rafts and caveolae provide the location of lipid signaling and interactions between these signaling pathways and mechanotransduction. Moreover, interactions between lipid signaling pathway molecules and mechanotransduction molecules have been observed. A better understanding of the lipid profile changes and the functional roles lipid metabolism plays in keloids will help to identify target molecules for the development of novel interventions that can prevent, reduce, or even reverse pathological scar formation and/or progression.

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Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions

Amini-Nik

Yousuf

Jeschke

2018

Advanced Drug Delivery Reviews

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In recent decades, there have been tremendous improvements in burn care that have allowed patients to survive severe burn injuries that were once fatal. However, a major limitation of burn care currently is the development of hypertrophic scars in approximately 70% of patients. This significantly decreases the quality of life for patients due to the physical and psychosocial symptoms associated with scarring. Current approaches to manage scarring include surgical techniques and non-surgical methods such as laser therapy, steroid injections, and compression therapy. These treatments are limited in their effectiveness and regularly fail to manage symptoms. As a result, the development of novel treatments that aim to improve outcomes and quality of life is imperative. Drug delivery that targets the molecular cascades of wound healing to attenuate or prevent hypertrophic scarring is a promising approach that has therapeutic potential. In this review, we discuss current treatments for scar management after burn injury, and how drug delivery targeting molecular signaling can lead to new therapeutic strategies.

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Keloids in rural black South Africans Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients

Cited by 25 publications

References 40 publications

The keloid phenomenon: Progress toward a solution

The keloid phenomenon: Progress toward a solution

Roles of lipid metabolism in keloid development

Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions

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