Keloids and Hypertrophic Scars

English, Robert S.; Shenefelt, Philip D.

doi:10.1046/j.1524-4725.1999.98257.x

Cited by 274 publications

(272 citation statements)

References 84 publications

Supporting

Mentioning

259

Contrasting

Unclassified

Order By: Relevance

“…In healthy dermis (HD) the collagen-fiber bundles are arranged in a parallel way to the epithelial surface and are interconnected by fine fibrillar strands of collagen [39]. Cutaneous keloids (K) and hypertrophic scars (HS) are examples of abnormal wound healing and are characterized by excessive dermal fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy

Cicchi¹,

Kapsokalyvas

Giorgi

et al. 2009

Journal of Biophotonics

200

View full text Add to dashboard Cite

Journal of BIOPHOTONICSWe have used nonlinear imaging to evaluate collagen organization in connective tissue ex-vivo samples. Image analysis methods were tested on healthy dermis, normal scars, and keloids. The evaluation of the second harmonic to autofluorescence aging index of dermis (SAAID) has allowed a first characterization of tissues by scoring the collagen/elastin content. Further analyses on collagen morphology in healthy dermis and keloids were performed by image-pattern analysis of SHG images. The gray-level co-occurrence matrix (GLCM) analysis method has allowed classification of different tissues based on the evaluation of geometrical arrangement of collagen fibrillar bundles, whereas a pattern analysis of the FFT images has allowed the discrimination of different tissues based on the anisotropy of collagen fibers distribution. This multiple scoring method represents a promising tool to be extended to other collagen disorders, as well as to be used in in-vivo skin-imaging applications.Slice of a sample of keloid labeled with H&E staining and imaged using nonlinear microscopy. Field of view: 1 Â 0.5 mm

show abstract

Section: Introductionmentioning

confidence: 99%

Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy

Cicchi¹,

Kapsokalyvas

Giorgi

et al. 2009

Journal of Biophotonics

200

View full text Add to dashboard Cite

show abstract

“…Title 17, USC, § 105 provides that "Copyright protection under this Any significant injury to the deep dermis, such as burns and other trauma, inflammation, or surgery, may result in wound healing that presents clinically with the formation of a scar. 1 Much time and energy has been spent attempting to classify scars on the basis of histopathology or clinical morphology. Although doing so is useful for documentation and management decisions, it belies the reality that a scar by itself is neither "good" nor "bad."…”

mentioning

confidence: 99%

Scar Management in the Pediatric and Adolescent Populations

Krakowski

Totri

Donelan³

et al. 2016

Pediatrics

View full text Add to dashboard Cite

For most children and adolescents who have developed symptomatic scars, cosmetic concerns are only a portion of the motivation that drives them and their caregivers to obtain treatment. In addition to the potential for cosmetic disfigurement, scars may be associated with a number of physical comorbidities including hypertrichosis, dyshidrosis, tenderness/pain, pruritus, dysesthesias, and functional impairments such as contractures, all of which may be compounded by psychosocial factors. Although a plethora of options for treating scars exists, specific management guidelines for the pediatric and adolescent populations do not, and evidence must be extrapolated from adult studies. New modalities such as the scar team approach, autologous fat transfer, and ablative fractional laser resurfacing suggest a promising future for children who suffer symptomatically from their scars. In this state-of-the-art review, we summarize cutting-edge scar treatment strategies as they relate to the pediatric and adolescent populations.

show abstract

“…PST hand piece has been designed and developed for "stamped" fractional photothermolysis techniques, as opposed to the scanning fractional techniques. The latter technique requires a scanner and in some systems expensive consumables [1,2,4].…”

Section: Discussionmentioning

confidence: 99%

“…Hypertrophic scars appear as hypo-pigmented or erythematous raised nodules or plaques containing excessive amounts of collagen, fibrin and proteoglycans [2,3]. In contrast, atrophic scars are dermal depressions with overlying thinned epidermis which results from a loss of dermal collagen following some types of inflammation or traumatic injury such as acne, varicella, post-traumatic wounds or post-operative scars [4].…”

Section: Introductionmentioning

confidence: 99%

“…Various treatments have been developed to improve the appearance of scars and to address these adverse effects, including silicone gel sheets, pressure garments, corticosteroid therapy, dermabrasion, surgical excision, chemical peels and more recently, laser treatments [7][8][9][10][11]. While some laser therapies have yielded positive results, others, such as the Nd: YAG and traditional ablative lasers, have actually worsened scar appearance [2,11,12]. Furthermore, traditional ablative treatments result in considerable patient downtime and adverse events such as oozing, infection, and hyper-pigmentation [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Study of fractional ablative laser in surgical and post traumatic scar

Sobhy¹,

Adel²,

Kamal³

2012

Our Dermatol Online

View full text Add to dashboard Cite

Introduction: Ablative, fractional lasers generate microscopic columns of coagulated tissue through the epidermis and dermis to evoke a wound healing response. In this study, we examined the efficacy and safety of fractional ablative 2940nm erbium: YAG laser in the treatment of surgical and post-traumatic scars. Fractional laser photothermolysis is the latest in the broad range of Er: YAG laser technique. This technique promises a novel means of providing treatments that would be as effective as traditional Er: YAG, while further reducing their down time and risk. Aim of the Work: The aim of this work is to assess the efficacy and safety of variable square pulse (VSP) fractional Er: YAG laser for the treatment of surgical and post-traumatic scars; both clinically and histopathologically. Methods: Clinical studies were conducted on a range of surgical and post-traumatic scars with a 2940nm erbium: YAG fractional ablative laser varying energy, pulse widths, treatment passes, and number of treatments: twenty subjects, with Fitzpatrick skin types III-IV, received two to five treatments at one month interval and a follow up period for 3 months. Clinical and histopathological evaluation of the results was performed. Results: Almost all patients improved both clinically and histopathologically. Clinical improvement in scars according to investigator assessment: 40% of patients had excellent improvement of 76-100% (grade 3), 50% of patients had good improvement of 50-75% (grade 2), 10% had fair improvement of 26-49% (grade 1) at three month follow up. Histologic findings demonstrated remodeling of scar tissue with renewal and reorganization of collagen fibers in the dermis was noted two weeks post-treatment. Conclusion: These data illustrate the safety and efficacy of the 2940nm erbium:YAG fractional ablative laser in the treatment of surgical and post-traumatic scars with short down time period, and almost no incidence of complication. StreszczenieWstęp: Ablacyjne lasery frakcyjne generują mikroskopijne kolumny poprzez koagulację tkanek naskórka i skóry właściwej wywołując reakcję gojenia ran. W tym badaniu zbadaliśmy skuteczność i bezpieczeństwo frakcyjnego ablacyjnego lasera erbowego 2940nm: YAG w leczeniu blizn chirurgicznych i pourazowych. Frakcyjna laserowa fototermoliza jest ostatnio techniką o szerokim zakresie Er: YAG. Technika ta obiecuje nowy sposób świadczenia zabiegów, które byłyby tak samo skuteczne jak tradycyjne Er: YAG, przy jednoczesnym zmniejszeniu ich czasu i ryzyka. Cel pracy: Celem niniejszej pracy jest ocena skuteczności i bezpieczeństwa stosowania zmiennego kwadratowego impulsu (VSP) frakcyjnego lasera Er: YAG do leczenia blizn chirurgicznych i pourazowych, zarówno pod względem klinicznym jak i histopatologicznym. Metody: Badania kliniczne prowadzone były w zakresie chirurgicznych i pourazowych blizn za pomocą frakcyjnego ablacyjnego lasera erbowego 2940nm: YAG różnej energii, szerokości impulsu, przebiegu leczenia i liczby zabiegów: dwudziestu pacjentów, z typami skóry Fitzpatrick III-IV...

show abstract

Keloids and Hypertrophic Scars

Cited by 274 publications

References 84 publications

Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy

Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy

Scar Management in the Pediatric and Adolescent Populations

Study of fractional ablative laser in surgical and post traumatic scar

Contact Info

Product

Resources

About