Keloidal atypical fibroxanthoma: a case series

Abstract

The diagnosis of keloidal AFX requires the exclusion of other malignant and benign lesions with keloidal or sclerotic collagen. Awareness of the rare variant of keloidal AFX may avoid a diagnostic pitfall leading to an erroneous diagnosis, particularly in small biopsies. The finding of sclerotic collagen preferentially deposited around vessels is an interesting and poorly understood phenomenon.

Atypical Fibroxanthoma: A Histological and Immunohistochemical Review of 171 Cases

“…Keloidal change is an unusual finding in AFX, which was only very recently recognised in the literature, in a series of 9 cases. 46 Fibrous tissue apparently replacing zones of 22 AFX suggested areas of regression. This concept has received little attention in the literature but could be an important feature, possibly leading to tumor involution.…”

Atypical fibroxanthoma: differential diagnosis from other sarcomatoid skin lesions

“…Keloidal AFX should always be considered when a mass containing keloidal collagen is encountered, particularly in small biopsies. 17 Myxoid AFX This recently-described variant is composed of a mixture of atypical pleomorphic and spindle cells in a prominently myxoid stroma. Myxoid change in AFX is rare, and it would be more likely on statistical grounds that a malignant myxoid cutaneous tumour represents another diagnostic entity.…”

“…17 It was originally considered to represent a reactive condition rather than a neoplastic lesion, but that premise has since been discredited. In the decades after its original description, reports of "metastasizing AFX" appeared in the literature.…”

Keloidal atypical fibroxanthoma on the back of an 80-year-old man, pitfalls in the clinical and histological diagnosis

“…Hsiao Yi-Hsin 1,2 , Chiu Cheng-Sheng 1,2 1 Department of Dermatology, Chang Gung Memorial Hospital, Taipei, 2 Chang Gung University College of Medicine, Taoyuan, Taiwan …”

“…Conversely, smaller group of patients present in their 4 th -5 th decade with AFX on the trunk and limbs without prominent actinic damage. [2] Our case is unique with the presentation of a keloidal AFX on the back, an uncharacteristic location for his demographic group, which raises the clinical diagnostic difficulties.…”