Kazal-type serine proteinase inhibitors from the black tiger shrimp Penaeus monodon and the inhibitory activities of SPIPm4 and 5

A Kazal type serine proteinase SPIPm2 from the black tiger shrimp Penaeus monodon is capable of neutralization and protection of hemocytes from the white spot syndrome virus

“…Though there are at least 9 different KPIs in the P. monodon, the SPIPm2 is the most abundant KPI [17,26]. It is expressed mainly in the shrimp hemocytes and may play important roles in the shrimp innate immunity [14,19,26].…”

“…Of the 9 KPI cDNA clones found in the EST database, the SPIPm2 cDNA clone is the most abundant in the hemocyte cDNA libraries [16,17]. It is, then, expected to have important function in the shrimp immune response.…”

Two Kazal-type protease inhibitors from Macrobrachium nipponense and Eriocheir sinensis: Comparative analysis of structure and activities

“…In crustaceans, numerous KPIs have been identified in recent years, most notably in the species Penaeus monodon [19,20], Litopenaeus vannamei [21], Fenneropenaeus chinensis [11,22] and Procambarus clarkii [23,24]. These KPIs are all expressed outside the male reproductive system and are believed to be involved in the innate immune response [25].…”

Three Kazal-type serine proteinase inhibitors from the red swamp crayfish Procambarus clarkii and the characterization, function analysis of hcPcSPI2

“…Recently, a variety of Kazal-type SPIs were found in crustaceans [10,11]. Several of these inhibitors are believed to be involved in innate immune response.…”