Kawasan Peristirahatan Dan Restoran Terapung Di Ruas Jalan Poros Makassar-Malino

Marwati, Marwati; Mutmainnah, Mutmainnah; Setiyadi, Rahmat

doi:10.24252/nature.v3i1a1

“…• Developed a rest area using a local architectural approach that is still thick with Bugis-Makassar customs and takes into account the relationship and proximity between facilities, ease of access and achievement [14].…”

Section: Rest Area Conceptmentioning

confidence: 99%

Rest Area Development in Central Java (Case Study: Rest Area on Semarang–Solo Toll Road)

Darmawan

¹

,

Sari

²

,

Werdiningsih

³

et al. 2021

IJSTT

0

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The construction of the road network is carried out to support the growth and acceleration of the economic process and the development of the tourism industry. It is also projected to improve the socio-economic conditions of the community. In the last few years, the Central Java Government has built toll roads to connect several cities in Central Java in one fast lane. However, it was not followed by the construction of supporting facilities such as rest area that serves a place to rest for motorists when they experience fatigue during long trips. The existence of the place is still limited, and it was not evenly distributed along the toll road, causing long queues at the entrance of some rest area when the volume of the vehicles is overflow. Based on these problems, the purpose of this research is to study and develop the requirement of rest area that can meet the needs of motorists traveling through the toll roads in Central Java. To achieve these objectives, this research used a qualitative descriptive method to describe and explain the problems in the field, and further analyze them to get a comprehensive result. The result of this research is presented in the form of published research reports and scientific articles. It is expected to provide benefits to the relevant scientific field, especially those related to architecture in developing rest areas that suit the needs of road users.

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“…• Developed a rest area using a local architectural approach that is still thick with Bugis-Makassar customs and takes into account the relationship and proximity between facilities, ease of access and achievement [14].…”

Section: Rest Area Conceptmentioning

confidence: 99%

Untitled

2021

IJSTT

0

View full text Add to dashboard Cite

The construction of the road network is carried out to support the growth and acceleration of the economic process and the development of the tourism industry. It is also projected to improve the socio-economic conditions of the community. In the last few years, the Central Java Government has built toll roads to connect several cities in Central Java in one fast lane. However, it was not followed by the construction of supporting facilities such as rest area that serves a place to rest for motorists when they experience fatigue during long trips. The existence of the place is still limited, and it was not evenly distributed along the toll road, causing long queues at the entrance of some rest area when the volume of the vehicles is overflow. Based on these problems, the purpose of this research is to study and develop the requirement of rest area that can meet the needs of motorists traveling through the toll roads in Central Java. To achieve these objectives, this research used a qualitative descriptive method to describe and explain the problems in the field, and further analyze them to get a comprehensive result. The result of this research is presented in the form of published research reports and scientific articles. It is expected to provide benefits to the relevant scientific field, especially those related to architecture in developing rest areas that suit the needs of road users.

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Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo₃ Ubiquinol Oxidase from Escherichia coli

Elamri

¹

,

Radloff

²

,

Hohmann

³

et al. 2020

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The respiratory chain of Escherichia coli contains two different types of terminal oxidase that are differentially regulated as a response to changing environmental conditions. These oxidoreductases catalyze the reduction of molecular oxygen to water and contribute to the proton motive force. The cytochrome bo3 oxidase (cyt bo3) acts as the primary terminal oxidase under atmospheric oxygen levels, whereas the bd‐type oxidase is most abundant under microaerobic conditions. In E. coli, both types of respiratory terminal oxidase (HCO and bd‐type) use ubiquinol‐8 as electron donor. Here, we assess the inhibitory potential of newly designed and synthesized 3‐alkylated Lawson derivatives through L‐proline‐catalyzed three‐component reductive alkylation (TCRA). The inhibitory effects of these Lawson derivatives on the terminal oxidases of E. coli (cyt bo3 and cyt bd‐I) were tested potentiometrically. Four compounds were able to reduce the oxidoreductase activity of cyt bo3 by more than 50 % without affecting the cyt bd‐I activity. Moreover, two inhibitors for both cyt bo3 and cyt bd‐I oxidase could be identified. Based on molecular‐docking simulations, we propose binding modes of the new Lawson inhibitors. The molecular fragment benzyl enhances the inhibitory potential and selectivity for cyt bo3, whereas heterocycles reduce this effect. This work extends the library of 3‐alkylated Lawson derivatives as selective inhibitors for respiratory oxidases and provides molecular probes for detailed investigations of the mechanisms of respiratory‐chain enzymes of E. coli.

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Kawasan Peristirahatan Dan Restoran Terapung Di Ruas Jalan Poros Makassar-Malino

Cited by 4 publications

References 0 publications

Rest Area Development in Central Java (Case Study: Rest Area on Semarang–Solo Toll Road)

Rest Area Development in Central Java (Case Study: Rest Area on Semarang–Solo Toll Road)

Untitled

Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo₃ Ubiquinol Oxidase from Escherichia coli

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Kawasan Peristirahatan Dan Restoran Terapung Di Ruas Jalan Poros Makassar-Malino

Cited by 4 publications

References 0 publications

Rest Area Development in Central Java (Case Study: Rest Area on Semarang–Solo Toll Road)

Rest Area Development in Central Java (Case Study: Rest Area on Semarang–Solo Toll Road)

Untitled

Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli

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Resources

About

Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo₃ Ubiquinol Oxidase from Escherichia coli