Kauranes as Anti-inflammatory and Immunomodulatory Agents: An Overview of In Vitro and In Vivo Effects

Mijares, Michael R.; Martínez, Gricelis; Sanctis, Juan B. De

doi:10.1007/978-981-16-4779-6_7

Cited by 3 publications

(1 citation statement)

References 179 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During inflammatory responses as a result of zymosan-induced inflammation, the actions of phagocytosis, cell migration, and the synthesis of proinflammatory mediators can be studied [ 18 ]. Zymosan has been shown to stimulate phagocytic cells, which increases the quantity of lysosomal enzymes secreted, boosts the release of proinflammatory cytokines including TNF- α and IL-6, and increases the leukotriene synthesis of monocytes, chemokines such as chemokine-C-X-C motif (CXCL-1), matrix metalloproteinase-9, and monocyte chemoattractant protein (MCP-1) [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Antwi-Adjei

Obese

Adakudugu

et al. 2023

The Scientific World Journal

View full text Add to dashboard Cite

Plant species have been used traditionally to treat numerous inflammatory disorders because of their known medicinal properties. This study aimed to assess the anti-inflammatory effect of aqueous ethanolic leaf extract of Persicaria lanigera using acute inflammatory models. The safety profile of the Persicaria lanigera extract was assessed using an acute toxicity model. The anti-inflammatory effect of the Persicaria lanigera leaf extract (100–600 mg·kg−1, p.o.) was studied in carrageenan-induced paw oedema, zymosan-induced knee joint arthritis, and histamine-induced paw oedema in Sprague–Dawley rats (n = 5). It was observed that the Persicaria lanigera leaf extract administered prophylactically significantly inhibited paw oedema from 99.01 ± 12.59 to 59.10 ± 4.94%, 56.08 ± 3.65%, and 48.62 ± 3.27% at 100 mg·kg−1, 300 mg·kg−1, and 600 mg·kg−1, while the standard drug, aspirin, showed 41.84 ± 9.25% in carrageenan-induced paw oedema, respectively. Furthermore, the extract decreased knee joint inflammation significantly from 62.43 ± 5.73% to 32.07 ± 2.98% and 24.33 ± 8.58% at 300 mg·kg−1 and 600 mg·kg−1 in zymosan-induced knee joint inflammation, respectively. In the histamine-induced paw oedema model, the extract significantly inhibited oedema to 61.53 ± 9.17%, 54.21 ± 9.38%, and 54.22 ± 9.37% at the same doses. Aqueous ethanolic leaf extract of Persicaria lanigera is safe and attenuates inflammation in acute inflammation models.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Antwi-Adjei

Obese

Adakudugu

et al. 2023

The Scientific World Journal

View full text Add to dashboard Cite

show abstract

High stereoselective semisynthesis of kauroxane and beyeroxane compounds

Villagómez-Guzmán,

Hernández-Padilla,

Rodríguez-García

et al. 2024

Journal of Molecular Structure

View full text Add to dashboard Cite

Pharmacological, Cytotoxic, Immunostimulant, and Auto-Immune Activity of Thalloid Liverworts: An Overview

2022

View full text Add to dashboard Cite

Bryophytes have historically been employed as verdant medicine in China, Native America and India. Phenolics, glycosides, fatty acids, other rare aromatic compounds and Terpenoids found in bryophytes may help prevent cancer and other chronic disorders. Liverworts have historically been utilized in traditional medicine and also as immu-nomodulators or immunostimulants. Diterpenoids, Lipophilic mono-, sesqui- and aromatic compounds assisting to the biological activities of liverworts. For their biological functions more than 220 aromatic compounds and 700 terpenoids and other chemicals discovered in liverworts scrutinized for their pharmacological, cytotoxic, immunostimulant and auto-immune efficacies.

show abstract

Kauranes as Anti-inflammatory and Immunomodulatory Agents: An Overview of In Vitro and In Vivo Effects

Cited by 3 publications

References 179 publications

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

High stereoselective semisynthesis of kauroxane and beyeroxane compounds

Pharmacological, Cytotoxic, Immunostimulant, and Auto-Immune Activity of Thalloid Liverworts: An Overview

Contact Info

Product

Resources

About