Karakteristik Klinis dan Patologis Karsinoma Nasofaring di Bagian THT-KL RSUP Dr.M.Djamil Padang

Faiza, Shofi; Rahman, Sukri; Asri, Aswiyanti

doi:10.25077/jka.v5i1.450

Cited by 15 publications

(20 citation statements)

References 8 publications

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“…The most common histopathological type found in this study was non-keratinizing squamous cell carcinoma as many as 25 subjects (83.3%) ( Table 1). Similar research conducted at M. Djamil Padang General Hospital also showed the highest number of nonkeratinizing squamous cell carcinoma types with a percentage of 75% [22]. However, the different results reported by extensive studies examining the epidemiology of NPC in Indonesia report the most cases in Indonesia are WHO type III (undifferentiated carcinoma), with a percentage of 85% [7].…”

Section: Discussionsupporting

confidence: 55%

Association of E-Cadherin Expression to Clinical Stage of Nasopharyngeal Carcinoma

Triastuti

Asnir

Yudhistira

et al. 2019

IJNPC

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Article InfoIntroduction: Nasopharyngeal carcinoma (NPC) has a high incidence rate in southern China and Southeast Asia and a high rate of metastasis in head and neck cancer. NPC is a squamous cell carcinoma that grows from the surface of the lateral wall of the nasopharynx. E-cadherin is known as a tumor suppressor protein and the loss of this expression in tumor cells is related to epithelial-mesenchymal transition that occurs during tumor development and metastasis. Objective: To determine the relationship between E-cadherin expression and clinical stage in patients with nasopharyngeal carcinoma. Methods: An analytical study with a cross-sectional study design, the number of samples was 30 patients with NPC who underwent immunohistochemical examination on KNF paraffin block. Result: Overexpression of E-cadherin was found in T1 and T2 of 15 subjects (100%). The overexpression of Ecadherin was found in lymph node N2 and N3 of 19 subjects (95%). The overexpression of E-cadherin was found in the histopathological type of Non-Keratinizing Squamous Cell Carcinoma of 24 subjects (96%). The overexpression of E-cadherin was found at an advanced stage of 26 subjects (100%). Conclusion: No significant association was found between E-cadherin expression and tumor size (p=1.000), lymph node metastasis (p=1.000), histopathological type (p=1.000) and tumor stage (p=0.133).

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Section: Discussionsupporting

confidence: 55%

Association of E-Cadherin Expression to Clinical Stage of Nasopharyngeal Carcinoma

Triastuti

Asnir

Yudhistira

et al. 2019

IJNPC

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“…Hal ini terlihat dari kejadian Karsinoma nasofaring yang bersifat endemik di Asia seperti Cina Selatan, Asia Tenggara, Jepang, dan Timur Tengah. Insiden karsinoma nasofaring tertinggi di dunia dijumpai pada penduduk daratan Cina bagian selatan, khususnya suku Kanton di provinsi Guang Dong dan daerah Guangxi dengan angka mencapai lebih dari 50 per 100.000 penduduk pertahun 3 . Secara umum, karsinoma nasofaring adalah kanker jarang dengan sekitar 80.000 kasus baru dilaporkan per tahun dan sekitar 0,7% dari semua kanker.…”

Section: Pendahuluanunclassified

“…Suatu penelitian deskriptif di RSUP Dr. M. Djamil Padang selama Juni 2010 sampai Juli 2013, didapatkan 44 kasus dimana 52,27% % laki-laki dan 47,22% perempuan dengan insiden puncak pada umur 41-65 tahun. 3 Di Medan, suatu penelitian deskriptif di RSUP H. Adam Malik pada tahun 2011, terdapat 151 pasien KNF dengan insiden puncak pada umur 41-50 tahun 5 . Selain itu, angka kejadian yang tercatat di RSUP Dr. Mohammad Hoesin Palembang selama tahun 2013 adalah 56 kasus 6 .…”

Section: Pendahuluanunclassified

Profil Klinis Karsinoma Nasofaring di Departemen THTKL RSUP Dr. Mohammad Hoesin Palembang Tahun 2014-2015

Dawolo¹,

Utama²,

Kasim³

2019

MKS

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Karsinoma nasofaring (KNF) adalah tumor ganas THTKL yang paling banyak dijumpai di Indonesia. Gejala dan tanda karsinoma nasofaring yang sering berupa benjolan di leher, obstruksi hidung, epistaksis dan diplopia.Penelitian ini bertujuan untuk mengetahui profil klinis karsinoma nasofaring di RSUP Dr. Mohammad Hoesin Palembang tahun 2014-2015.Penelitian ini merupakan penelitian deskriptif berupa serial kasus dengan menggunakan data sekunder dari rekam medis pasien di RSUP Dr. Mohammad Hoesin Palembang. Sampel penelitian ini adalah semua rekam medik pasien karsinoma nasofaring di RSUP Dr. Mohammad Hoesin Palembang tahun 2014-2015. Pada tahun 2014 terdapat sebanyak 60 kasus (16,85%) dan pada tahun 2015 terdapat 50 kasus (14,53%) dari total pasien KNF yang datang ke RSMH. Pasien KNF paling banyak (30,91%) terdapat pada kelompok usia 46-55 tahun. Sebanyak 72,73% pasien KNF adalah laki-laki. Gejala yang paling sering ditemui adalah hidung tersumbat (49,09%), benjolan di leher (43,64%), dan mimisan (36,36%). Sebanyak 81,82% kasus KNF adalah KNF WHO III, selebihnya adalah KNF WHO II (15,45%) KNF WHO I (2,73%). Mayoritas kasus KNF adalah KNF stadium IV (77,27%). Pasien KNF paling banyak terdapat pada kelompok usia 46-55 tahun. KNF lebih sering terjadi pada laki-laki daripada perempuan. Gejala klinik yang paling sering ditemui adalah hidung tersumbat, benjolan di leher dan mimisan. Mayoritas gambaran histopatologi KNF adalah KNF WHO III. Sebagian besar penderita KNF didiagnosis sebagai KNF stadium IV.

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“…This shows patients come in the late stage. Nasopharyngeal carcinoma often shows minimal or unspecific sign, so it often found in late stage with lymph node enlargement and intracranial invasion [9]. The proportion of allele rs2070672 CYP2E1 gene in subjects with undifferentiated type NPC in this study was 18 AA allele (27.7%), AG allele in 8 subjects (12.3%), and GG allele in 39 subjects (60.0%).…”

Section: Resultsmentioning

confidence: 51%

“…The diagnosis of NPC is often made late because the location of the nasopharynx is hidden behind the nasal cavity and under the base of the skull so that NPC patients generally come for treatment at an advanced stage. In addition, NPC often exhibits minimal or nonspecific symptoms so it often found at an advanced stage with enlarged lymph nodes and intracranial invasion [9].…”

Section: Discussionmentioning

confidence: 99%

COMPARISON OF POLYMORPHISM rs2070672 CYP2E1 GENE PROPORTION IN EARLY AND ADVANCED STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA IN BALINESE

Suanda

Nuaba

Susanthi

2020

IJNPC

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Introduction: Nasopharyngeal carcinoma is the most common malignancy in the ENT field. The cause of nasopharyngeal carcinoma is multifactorial. One of the risk factors for an increase in nasopharyngeal carcinoma is the rs2070672 polymorphism of the CYP2E1gene. Purpose: To determine the rs2070672 CYP2E1gene polymorphism proportion in early and advanced stage undifferentiated type NPC subjects in Balinese. Method: This research is a cross sectional comparative study. The case population were all subjects with undifferentiated type NPC in the ENT outpatient clinic at Sanglah General Hospital Denpasar. This study uses 65 samples. Data collected in the form of subject characteristics and rs2070672 CYP2E1gene polymorphisms which examined by ARMS-PCR technique. Results: The average age of the sample was 48.1 years, the most were male as many as 48 subjects (73.8%), and the highest was advanced stage as many as 56 subjects (86.2%). In the chi square test the proportion of polymorphisms in the advanced stage was 2.357 times higher than the early stages. The results of multivariate analysis using logistic regression proved that the rs2070672 CYP2E1gene polymorphism at advanced stage was 7.469 times higher than early stage. Conclusion: There is a difference in the proportion of rs2070672 CYP2E1gene polymorphism in undifferentiated type NPC of Balinese, where advanced stage is higher than early stage.

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Karakteristik Klinis dan Patologis Karsinoma Nasofaring di Bagian THT-KL RSUP Dr.M.Djamil Padang

Cited by 15 publications

References 8 publications

Association of E-Cadherin Expression to Clinical Stage of Nasopharyngeal Carcinoma

Association of E-Cadherin Expression to Clinical Stage of Nasopharyngeal Carcinoma

Profil Klinis Karsinoma Nasofaring di Departemen THTKL RSUP Dr. Mohammad Hoesin Palembang Tahun 2014-2015

COMPARISON OF POLYMORPHISM rs2070672 CYP2E1 GENE PROPORTION IN EARLY AND ADVANCED STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA IN BALINESE

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