Karakteristik Klinis Dan Derajat Berat Gejala Motorik Penyakit Parkinson Di Rsup Sanglah Dan Rsud Wangaya Denpasar

Abstract

Background: Parkinson's Disease (PD) is the second most common neurodegenerative disorder. The Global Burden Disease (GBD) report published in 2018 estimated there were 6.1 million individuals suffering from PD globally and causing 3.2 million Disability-Adjusted Life Years (DALY) and 211,296 deaths in 2016. Disability mainly caused by motor symptoms. This study aims to determine the clinical characteristics and motor severity in PD patients in Sanglah and Wangaya General Hospital Denpasar. Method: Descriptive observational study with cross-sectional design. Samples taken consecutively from all patients diagnosed with PD at Neurology Polyclinic in Sanglah and Wangaya General Hospital from December 2018 - February 2019. Result: From 47 subjects with PD, 72.3% were male, 83% had onset within 1-5 years, and the mean age was 63.87 ± 8.67 years. As many as 44.7% subjects had Hoehn-Yahr 2 stadium, with an average MDS-UPDRS III score of 35.11 ± 21.39, and 48.9% subjects had mild severity. As many as 59.6% subjects had the status of ON. Motor severity showed a trend that increases with increasing staging, but was not seen when compared to the onset. This result might be affected by the ON/OFF status during examination. Conclusion: Parkinson's disease in Sanglah and Wangaya General Hospital is more common in men and over the age of 50 years, and most are found in moderate severity. There is a trend of worsening motor severity with the increasing Hoehn-Yahr stadium. Examination using UPDRS-III is recommended to be done both on ON and OFF state to get more sensitive results

Correlation between cholesterol levels and the severity of Parkinson disease

“…13 The results of this study also did not show a correlation between HDL and PD. [13][14][15][16][17][18][19] However, the results of this study are different from the results of research conducted by Agustin et al in Yogyakarta in 2017 which showed no significant difference in LDL levels to the severity of PD based on the H and Y scale. 11 The difference in the results of this study is due to the fact that there are many factors that can changes the mechanism and pathophysiology of dopaminergic cells in patients with PD that affect disease progression and the differences in the statistical test methods of this study with those of Agustin et al The effect of cholesterol levels on the biologic progression of PD is unknown, but it has been suggested that cholesterol may facilitate the repair of injured neuronal pathways in Parkinson's disease.…”

“…Only 6.7% of patients came with stage H and Y IV and 1.7% H and Y V, this may be explained by limited patient mobility so that patients do not come routinely to the clinic for control. 15,16 Some PD patients in this study used more than two drugs (53.33%). Several previous studies obtained almost have the same results by Oktariza et al in Bandung whereas patients usually consume more than two types of drugs (54.54%) and Agustin et al in 2017 in Yogyakarta the majority of patients used two types of Parkinson's drugs (60%).…”

“…13 Another study whose results were quite different from the characteristics of PD patients was obtained in a study by Oktariza et al in 2019 in Bandung, female were more dominant (51.52%) than male (48.48%) and Larasanti et al in Denpasar in 2019 (male 72.3% compared with female 27.7 %). 14,15 The majority of patients with PD are men due to the influence of the female hormone estrogen which is neuroprotective and the risk of head trauma, which is one of the risk factors for PD is greater in men than women. 15 The This study also found that more than half of the study subjects had onset of symptoms within 5 years (75%).…”

“…14,15 The majority of patients with PD are men due to the influence of the female hormone estrogen which is neuroprotective and the risk of head trauma, which is one of the risk factors for PD is greater in men than women. 15 The This study also found that more than half of the study subjects had onset of symptoms within 5 years (75%).…”

“…Bandung in 2019 (mean age 61.03±9.12) and Huang et al in the United States in 2007 (mean age 63.7±11.4) 11,[13][14][15]. …”