Karakteristik dan Stabilitas Fisik NLC-Koenzim Q10 dalam Sleeping Mask dengan Minyak Nilam

Mayangsari, Fransisca Dita; Erawati, Tristiana; Soeratri, Widji; Rosita, Noorma

doi:10.20473/jfiki.v8i22021.178-186

Cited by 6 publications

(14 citation statements)

References 15 publications

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“…It was in line with the literature, i.e. 4.5 -6.8 (Mayangsari et al, 2021). The NLC-GTE preparation with the addition of alpha-lipoic acid has more acidic pH.…”

Section: Results and Discussion Physical Characteristic Test Organole...supporting

confidence: 90%

“…It was supported by Lason et al (2017) research that the particle size of the NLC base without alphalipoic acid was smaller than the NLC preparation containing the active ingredient alpha-lipoic acid. However, the particle size of F2 was still within the range for NLC preparations, below 1000 (Mayangsari et al, 2021). For the results of the polydispersity index, the results were below 0.3, i.e., 0.263 ± 0.007 for F1 and 0.272 ± 0.033 for F2.…”

Section: Results and Discussion Physical Characteristic Test Organole...mentioning

confidence: 78%

“…Observations of particle size values in F1 and F2 were conducted on days 0 and 6, resulted that there was a change in particle size but still according to the literature, which has a value below 1000 nm (Mayangsari et al, 2021). In F1 and F2, statistical tests were carried out using the Paired-Sample T-Test with α = 0.05.…”

Section: Physical Stability Testingmentioning

confidence: 99%

“…Meanwhile, NLC is a modification of SLN, which forms lower crystallinity so that EE is higher and has better stability than SLN (Frias et al, 2016). It is because NLC contains liquid lipids, which can reduce crystallinity to accommodate more active ingredients (Mayangsari et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability of NLC-Green Tea Extract

Afra

Soeratri

Purwanto

2022

JFIKI

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Background: The addition of alpha-lipoic acid in Nanostructured Lipid Carrier-Green Tea Extract (NLC-GTE) has potential to increase effectiveness of anti-aging preparations. It happened because alpha-lipoic acid can increase stability and antioxidant activity. Objective: Comparing the physical characteristics and stability of NLC-GTE with or without alpha-lipoic acid. Methods: NLC-GTE manufactured using the High Shear Homogenization method. NLC-GTE was divided into two formulas, without the addition of alpha-lipoic acid for F1 and with the addition of alpha-lipoic acid for F2. The characteristics and physical stability were tested, including organoleptic, pH, particle size, and polydispersity index. Stability test was held using the thermal cycling method. Results: Based on characteristic test, it was found that F2 had larger particle size value than F1. The average particle size value of F1 is 313.9 ± 0.76 nm and 423.4 ± 0.75 nm for F2. The F1 and F2 preparations had a polydispersity index value below 0.3, so they were homogeneous. The average pH value of F1 is 5.998 ± 0.01, and F2 is 4.798 ± 0.004. The physical stability test showed a difference before and after the sixth day in particle size and pH, but it was still in the range, so it was safe. However, there was a separation in F1 after day 6. Conclusion: Based on the characteristics and physical stability tests, F1 (without alpha-lipoic acid) and F2 (with alpha-lipoic acid) had differences in particle size and pH. From the physical stability test, it can be concluded that F2 is more stable than F1.

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“…It was in line with the literature, i.e. 4.5 -6.8 (Mayangsari et al, 2021). The NLC-GTE preparation with the addition of alpha-lipoic acid has more acidic pH.…”

Section: Results and Discussion Physical Characteristic Test Organole...supporting

confidence: 90%

Section: Results and Discussion Physical Characteristic Test Organole...mentioning

confidence: 78%

Section: Physical Stability Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability of NLC-Green Tea Extract

Afra

Soeratri

Purwanto

2022

JFIKI

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“…Kemudian larutan diambil sebanyak 2,0 ml lalu ditambah 8 mL aquademineral. Diaduk kembali dengan keceptan 100 rpm selama 10 menit (13).…”

Section: Ukuran Partikel Dan Indeks Polidispersitas (Ip)unclassified

Pengaruh Waktu Pengadukan Terhadap Karakteristik Fisik Nanostructured Lipid Carriers Menggunakan Metode High Shear Homogenization

Fachriani

Safitri²,

Chasanah³

et al. 2022

Maj. Farmasetika

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NLC (Nanostructured Lipid Carrier) merupakan generasi kedua dari SLN (Solid Lipid Nanopartikel). Salah satu metode yang dapat digunakan untuk pembuatan NLC adalah HPH (High Shear Homogenization). Waktu pengadukan merupakan salah satu faktor yang mempengaruhi ukuran partikel NLC. Tujuan dari penelitian ini adalah melakukan analisa pengaruh variasi waktu pengadukan terhadap karakteristik fisik NLC. Variasi lama pengadukan yang diamati adalah 26 menit-5 siklus (sampel A) ; 30 menit-6 siklus (sampel B) ; 34 menit-7 siklus (sampel B). Ketiga sampel uji dibuat menggunakan kecepatan 5000 rpm. Karakteristik fisik yang diamati meliputi ukuran partikel, indeks polidispersitas, pH dan viskositas. Data yang didapatkan dianalisa secara statistik menggunakan One Way Anova. Hasil uji ukuran partikel menunjukkan bahwa ketiga sampel memiliki ukuran partikel yang memenuhi spesifikasi. Ukuran partikel ketiga sampel berada pada rentang 137,23 – 147,77 nm. Sampel yang memiliki ukuran partikel paling kecil adalah sampel B. Namun, sampel B memiliki indeks polidispersitas yang lebih besar daripada sampel A dan B, yaitu 0,452 ± 0,007. Berdasarkan uji organoleptis, diketahui bahwa ketiga sampel tidak memiliki perbedaan. Ketiganya memiliki warna putih, beraroma sedikit lemak dan konsistensi encer / cair. Uji pH menunjukkan bahwa pH ketiga sampel sama, yaitu 6,85-6,87. Berdasarkan uji viskositas ketiga formula memiliki viskositas yang berbeda. Sampel yang memiliki viskositas paling tinggi adalah sampel B dengan nilai 55,30 ± 0,26 cP. Walaupun memiliki nilai viskositas berbeda, tetapi ketiga formula memiliki konsistensi yang sama, yaitu encer. Waktu pengadukan yang terpilih adalah 26 menit dengan 5 siklus karena lebih efisien dari segi waktu dibandingkan waktu pengadukan yang lain. Kata kunci: karakteristik fisik, NLC, waktu pengadukan

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Formulasi sleeping mask ekstrak daun teh hijau (Camellia sinensis L.) dengan variasi konsentrasi karbopol 940 dan uji aktivitas sebagai antibakteri terhadap Propionibacterium acnes

Nurhaini,

Turahman,

Aisiyah

2024

Pharmasipha

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Sleeping mask is a skin care product that can moisturize and treat acne. Green tea leaves contain flavonoids, tannins and alkaloids as antibacterial activity. Green tea leaves are macerated with 96% ethanol. The green tea leaf extract obtained is made into a sleeping mask. This research aims to determine the green tea leaf extract sleeping mask preparation against Propionibacterium acnes, and the effect of gelling agent variations on physical quality tests, as well as to find out the best formula by looking at physical quality and stability tests and has good antibacterial activity. Making sleeping masks with carbopol variations of 0.5, 1, and 1.5% using green tea leaf extract obtained from maceration with 96% ethanol solvent. Sleeping preparations were tested for Propionibacterium acnes antibacterial activity and physical quality and stability tests. Antibacterial activity testing using disc diffusion. The research results were analyzed statistically using one-way ANOVA and Kruskal-wallis methods. The results of this research show that green tea leaves have antibacterial activity with an inhibitory zone of 9.5mm, the variation of carbopol 940 can influence the physical quality and stability tests and the resulting inhibition zone, and the best formula is formula II because it meets the physical quality test and pH stability of 5.73 spreadability 5cm, adhesion power 2.49 seconds and viscosity 37.533 and antibacterial activity 7.30 mm. Keywords: : antibacterial, green tea leaves, carbopol 940, sleeping mask ABSTRAK Sleeping mask merupakan produk perawatan kulit yang dapat melebabkan dan mengatasi jerawat. Daun teh hijau memiliki kandungan flavonoid, tanin dan alkaloid sebagai aktivitas antibakteri. Sebuk Daun teh hijau dimaserasi dengan etanol 96%. Ekstrak daun teh hijau yang diperoleh, dibuat dalam sediaan sleeping mask. Penelitian ini bertujuan untuk mengetahui sediaan sleeping mask ekstrak daun teh hijau terhadap propionibacterium acnes, dan pengaruh variasi gelling agent terhadap uji mutu fisik, serta untuk mengetahui formula terbaik dengan melihat uji mutu fisik dan stabilitas serta mempunyai aktivitas antibakteri yang baik. Pembuatan sleeping mask dengan variasi karbopol 0,5, 1, dan 1,5% menggunakan ekstrak daun teh hijau yang diperoleh dari maserasi dengan pelarut etanol 96%. Sediaan sleeping diuji aktivitas antibakteri Propionibacterium acnes dan uji mutu fisik serta stabilitas. Pengujian aktivitas antibakteri menggunakan difusi cakram. Hasil penelitian dianalisis secara statistic dengan metode one-way ANOVA dan Kruskal-wallis. Hasil penelitian ini menunjukan bahwa daun teh hijau memiliki aktivitas antibakteri dengan zona hambat 9,5mm, variasi karbopol 940 dapat memengaruhi uji mutu fisik dan stabilitasdan zona hambat yang dihasilkan, serta formula terbaik yaitu formula II karena memenuhi uji mutu fisisk serta stabilitas pH 5,73 daya sebar 5cm daya lekat 2,49 detik dan viskositas 37,533 serta aktivitas antibakteri 7,30 mm. Kata kunci: Antibakteri, daun teh hijau, karbopol 940, sleeping mask

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Karakteristik dan Stabilitas Fisik NLC-Koenzim Q10 dalam Sleeping Mask dengan Minyak Nilam

Cited by 6 publications

References 15 publications

Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability of NLC-Green Tea Extract

Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability of NLC-Green Tea Extract

Pengaruh Waktu Pengadukan Terhadap Karakteristik Fisik Nanostructured Lipid Carriers Menggunakan Metode High Shear Homogenization

Formulasi sleeping mask ekstrak daun teh hijau (Camellia sinensis L.) dengan variasi konsentrasi karbopol 940 dan uji aktivitas sebagai antibakteri terhadap Propionibacterium acnes

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