KARAKTERISASI SIMPLISIA DAN EKSTRAK DAUN BANDOTAN (Ageratum conyzoides L) SEBAGAI KANDIDAT OBAT KARIES GIGI

Abstract

ABSTRAKDaun Bandotan (Ageratum conyzoides L) mempunyai aktivitas untuk menghambat pertumbuhan bakteri Streptococus mutans yang menyebabkan terjadinya karies pada gigi. Tujuan penelitian ini untuk menetapkan standar mutu dan keamanan dari simplisia dan ekstrak Daun Bandotan. Penelitian ini bersifat non eksperimental, yang meliputi pengambilan sampel, determinasi, pembuatan simplisia, pembuatan ekstrak menggunakan pelarut etanol dengan metode maserasi. Uji karakteristik meliputi organoleptik, mikroskopik, skrining fitkomia menggunakan profil Kromatografi Lapis Tipis (KLT), penetapan kadar zat terlarut dalam air, kadar zat terlarut dalam etanol, kadar abu total, kadar tidak larut asam dan susut pengeringan. Karaktersitik organoleptik simplisia daun bandotan berwarna hijau tua, rasa pahit dan sepat bau aromatik khas bandotan. Ekstraknya berwarna hijau kehitaman bau aromatik khas bandotan rasa sangat pahit. Skrining fitokimia ekstrak daun bandotan mengandung senyawa alkaloid, steroid dan flavonoid. Uji mikroskopik simplisia daun bandotan terdapat rambut penutup, epidermis atas dan bawah, dinding bergelombang dengan stomata tipe anomistik, mesofil meliputi jaringan palisade. Persentase larut air simplisia dan ekstrak adalah 2% dan 2,4%. Persentase larut etanol adalah 12,9% dan 9,5%. Persentase kadar abu total 25,5% dan 51%. Persentase kadar abu larut air adalah 10% dan 7,35%. Persentase kadar abu tidak larut asam adalah 9,7% dan 2,5%. Persentase susut pengeringan adalah 11% dan 75%. ABSTRACTBandotan leaves (Ageratum conyzoides L) has an activity to inhibit the growth of Streptococus mutans bacteria cause dental caries. This Research was designed to establish quality and safety standards for simplicia and Bandotan leaves extracts. This research is non-experimental, which includes sampling, determination, making simplicia, and extraction. Characterization tests including organoleptic, macroscopic, microscopic, phytochemicals screening using TLC, determination of soluble water content, soluble ethanol content, total ash content, water soluble in ash content, acid insoluble in ash content and decrease drying. Organoleptic characteristics of simplicia test showed dark green, has bitter taste

Screening of Secondary Metabolite Photochemicals Extract 96% Leaf’s Mahkota Dewa (Phaleria Macrocarpa) in the Coastal Area of Bengkulu City, Indonesia

“…positive for alkaloids in Dragendrof's reagent. " In accordance with the theory (Marliana et al, 2005) and the same was done by Ika Ayu Mentari et al, 2020, but in Ika Ayu's research as an herbal medicine to treat dental caries. " It is estimated that the precipitate is potassium-alkaloids.…”

“…in this study were positive for tannins. Meanwhile, for tannin compounds using a gelatin solution, there is no white precipitate, meaning that it contains negative tannins, the same as what was done by Mentari IA et al, 2020 where the ethanol extract of bandotan leaves did not contain tannins. "…”

Effectiveness of Biopesticides Nicotiana tabacum L and Ageratum conyzoides L As Controlling Spodoptera exigua in Red Onion (Allium ascalonicum L.)

“…Meanwhile, babadotan extract contains flavonoids, terpenoids, steroids, saponins and tannins. In research (Mentari et al, 2020) that babadotan extract contains secondary metabolite compounds such as flavonoids and steroids. Purwanti, (2022) states that babadotan extract also contains flavonoids, steroids, saponins and tannins.…”

MikrobatX: The Use of SIFT Feature Extraction in a Deep Learning Approach for Identification and Classification of Microscopic Fragments of Medicinal Leaves

“…Medicinal plant research articles still lack information about microscopic tests. Some of them only mention microscopic fragments without discussing the truth of the simplicia material, which should be the goal of the test [3]- [8]. In addition, some studies are limited to looking for the characteristics of the content of Simplicia with microscopic tests [9], [10].…”