Kaposi Sarcoma After Bilateral Lung Transplantation

Martínez, Santiago; McAdams, H. Page; Youens, Kenneth E.

doi:10.1097/rti.0b013e3181585bc4

Cited by 22 publications

(13 citation statements)

References 9 publications

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“…In the ISHLT registry, at least one malignancy was reported in 13% of lung transplant recipients who survived five yr and in 28.2% who survived 10 yr. The most common malignancies were lymphoma and skin cancer, but other types of malignancies such as Kaposi sarcoma, breast, lung, and colon carcinoma among others have been reported after SOT . Although the higher cancer rate is thought to be due to the immunosuppressive therapy given to recipients and to the baseline risk factor of the patient , radiation exposure may also contribute an additional cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Radiation exposure and attributed cancer risk following lung transplantation

Rosengarten

Raviv

Rusanov

et al. 2014

Clinical Transplantation

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Section: Discussionmentioning

confidence: 99%

Radiation exposure and attributed cancer risk following lung transplantation

Rosengarten

Raviv

Rusanov

et al. 2014

Clinical Transplantation

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“…To the best of our knowledge, there are a few cases of Kaposi sarcoma with only graft involvement and only 1 previous report with lung allograft involvement without any related symptoms. [8][9][10] The succession of this unfortunate case underlines the potential morbidity of transplant-related Kaposi sarcoma and the need to maintain a high level of suspicion for Kaposi sarcoma in this population, even in the absence of cutaneous involvement and significant initial respiratory distress.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Nannini

Rebusso²,

Lunardi³

et al. 2017

Exp Clin Transplant

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“…One of the significant advantages of FDG PET/CT is its routine whole-body acquisition, which is ideal for systemic disease such as KS. In the radiology literature, there were a few case reports about applications of FDG PET/CT for AIDS-defining KS, which all suggested that FDG PET-CT was effective in detecting clinically occult KS lesions that were difficult to diagnose with traditional imaging techniques in more advanced stages of KS [14][15][16][17][18].…”

Section: Kaposi's Sarcomamentioning

confidence: 98%

Demonstrations of AIDS-associated malignancies and infections at FDG PET-CT

Liu

2011

Ann Nucl Med

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HIV infection results in profound alterations of immunologic function that render the patient severely immunocompromised, and susceptible to malignancies and opportunistic infections. Three AIDS-defining malignancies include Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL) and invasive cervical cancer. In AIDS patients, KS is often aggressive and multifocal, with visceral involvement and widespread cutaneous and nodal spread; NHL is always high grade and often widely disseminated at the time of diagnosis with frequent involvement of extranodal sites; cervical cancer is invasive and has greater likelihood of progression and metastasis. Although there are very sparse systemic data available in the literature, limited studies has shown that FDG PET-CT is a valuable imaging technique in the diagnosis, staging, restaging and monitoring therapeutic response in these malignancies. In addition, a unique application of FDG PET/CT is the differentiation of cerebral lesions between lymphoma and toxoplasmosis in AIDS patients, which cannot be reliably achieved with either CT or MRI. HIV-associated opportunistic infections may involve different pathogens and multiple tissues, organs or systems. Some preliminary observations have revealed a promising role of FDG PET-CT in the diagnosis and identification of these infections such as tuberculosis, fever of unknown origin, pneumocystis pneumonia and candidiasis. However, it should be stressed that FDG PET-CT alone has no role in identifying the pathology of abnormalities. FDG PET-CT, at best, can localize the sites of abnormalities and impact on patient's management in clinical decision making.

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Kaposi Sarcoma After Bilateral Lung Transplantation

Cited by 22 publications

References 9 publications

Radiation exposure and attributed cancer risk following lung transplantation

Radiation exposure and attributed cancer risk following lung transplantation

Untitled

Demonstrations of AIDS-associated malignancies and infections at FDG PET-CT

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