Kaolin-Based Activated Coagulation Time Measured by Sonoclot in Patients Undergoing Cardiopulmonary Bypass

Ganter, Michael T.; Monn, Antoinette; Tavakoli, Reza; Klaghofer, Richard; Zollinger, Andreas; Hofer, Christoph K.

doi:10.1053/j.jvca.2006.12.012

Cited by 17 publications

(8 citation statements)

References 22 publications

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“…However, others found the Sonoclot® Analyzer to be valuable and reliable in patients undergoing cardiac surgical procedures (24,25) and the Sonoclot® Analyzer has even demonstrated a precision close to that of thrombelastography (26). In more recent studies, test variability of ACT values determined by Sonoclot® were comparable to other established ACT analyzers (8-9% on average) (15)(16)(17)(18).…”

Section: Sonoclot Analysismentioning

confidence: 96%

“…This onset of clot formation is defined as an upward deflection of the Sonoclot® Signature. Sonoclots' ACT corresponds to the conventional ACT measurement, provided that cuvettes containing a high concentration of a typical activators (celite, kaolin) are being used (15)(16)(17)(18). The Sonoclot® Analyzer has been criticized because its results were influenced by age, sex, and platelet count (21).…”

Section: Sonoclot Analysismentioning

confidence: 99%

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Coagulation Monitoring: Current Techniques and Clinical Use of Viscoelastic Point-of-Care Coagulation Devices

Ganter

Hofer

2008

Anesthesia &Amp; Analgesia

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612

513

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Perioperative monitoring of blood coagulation is critical to better understand causes of hemorrhage, to guide hemostatic therapies, and to predict the risk of bleeding during the consecutive anesthetic or surgical procedures. Point-of-care (POC) coagulation monitoring devices assessing the viscoelastic properties of whole blood, i.e., thrombelastography, rotation thrombelastometry, and Sonoclot analysis, may overcome several limitations of routine coagulation tests in the perioperative setting. The advantage of these techniques is that they have the potential to measure the clotting process, starting with fibrin formation and continue through to clot retraction and fibrinolysis at the bedside, with minimal delays. Furthermore, the coagulation status of patients is assessed in whole blood, allowing the plasmatic coagulation system to interact with platelets and red cells, and thereby providing useful additional information on platelet function. Viscoelastic POC coagulation devices are increasingly being used in clinical practice, especially in the management of patients undergoing cardiac and liver surgery. Furthermore, they provide useful information in a large variety of clinical scenarios, e.g., massive hemorrhage, assessment of hypo- and hypercoagulable states, guiding pro- and anticoagulant therapies, and in diagnosing of a surgical bleeding. A surgical etiology of bleeding has to be considered when viscoelastic test results are normal. In summary, viscoelastic POC coagulation devices may help identify the cause of bleeding and guide pro- and anticoagulant therapies. To ensure optimal accuracy and performance, standardized procedures for blood sampling and handling, strict quality controls and trained personnel are required.

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Section: Sonoclot Analysismentioning

confidence: 96%

Section: Sonoclot Analysismentioning

confidence: 99%

Coagulation Monitoring: Current Techniques and Clinical Use of Viscoelastic Point-of-Care Coagulation Devices

Ganter

Hofer

2008

Anesthesia &Amp; Analgesia

Self Cite

612

513

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show abstract

“…The Sonoclot analyzer has been used in human patients to improve hemostasis management during cardiac and liver surgery, provide rapid identification of mechanical versus hemostatic surgical bleeders (eg, a slipped ligature versus a coagulopathy), reduce the use of blood products, accurately and inexpensively manage anticoagulation therapy, and identify hyper‐ and hypocoagulable patients. This methodology has not been evaluated for use in small animal patients, although it has been used to evaluate hemostatic and platelet dysfunction in critically ill neonatal foals …”

Section: Introductionmentioning

confidence: 99%

Sonoclot evaluation of whole blood coagulation in healthy adult dogs

Babski¹,

Brainard²,

Krimer

et al. 2012

J Vet Emergen Crit Care

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“…The Son ACT value corresponds to the conventional ACT measurement and is used to guide heparin therapy. 20 In contrast, the analogous value R (reaction time) in TEG and as CT (clot time) in rotation thromboelastometry reflects a more developed and later stage of initial clot formation. Tanaka et al found that R values of TEG were 1.5-fold (native blood samples) and 3.9-fold (heparinized samples) higher as compared with ACT values determined by Sonoclot.…”

Section: Discussionmentioning

confidence: 99%

Utility of Sonoclot in Prediction of Postoperative Bleeding in Pediatric Patients Undergoing Cardiac Surgery for Congenital Cyanotic Heart Disease: A Prospective Observational Study

Rajkumar

Kumar

Dutta

et al. 2017

Journal of Cardiothoracic and Vascular Anesthesia

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Kaolin-Based Activated Coagulation Time Measured by Sonoclot in Patients Undergoing Cardiopulmonary Bypass

Cited by 17 publications

References 22 publications

Coagulation Monitoring: Current Techniques and Clinical Use of Viscoelastic Point-of-Care Coagulation Devices

Coagulation Monitoring: Current Techniques and Clinical Use of Viscoelastic Point-of-Care Coagulation Devices

Sonoclot evaluation of whole blood coagulation in healthy adult dogs

Utility of Sonoclot in Prediction of Postoperative Bleeding in Pediatric Patients Undergoing Cardiac Surgery for Congenital Cyanotic Heart Disease: A Prospective Observational Study

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