Anesthetic-induced and constitutive gene regulatory control of myocardial substrate metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery. The authors' analysis further points to novel cardiac survival pathways as potential therapeutic targets in perioperative cardioprotection.

The goal of normothermia during off-pump coronary artery bypass grafting was best achieved by the Allon system. With this concept, overall blood loss and transfusion requirements were reduced, hence indicating improved quality of perioperative care.

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In gradient-based automatic history matching, calculation of the derivatives (sensitivities) of all production data with respect to gridblock rock properties and other model parameters is not feasible for large-scale problems. Thus, the Gauss-Newton (GN) method and Levenberg-Marquardt (LM) algorithm, which require calculation of all sensitivities to form the Hessian, are seldom viable. For such problems, the quasi-Newton and nonlinear conjugate gradient algorithms present reasonable alternatives because these two methods do not require explicit calculation of the complete sensitivity matrix or the Hessian. Another possibility, the one explored here, is to define a new parameterization to radically reduce the number of model parameters.We provide a theoretical argument that indicates that reparameterization based on the principal right singular vectors of the dimensionless sensitivity matrix provides an optimal basis for reparameterization of the vector of model parameters. We develop and illustrate algorithms based on this parameterization. Like limited-memory Broyden-Fletcher-Goldfarb-Shanno (LBFGS), these algorithms avoid explicit computation of individual sensitivity coefficients. Explicit computation of the sensitivities is avoided by using a partial singular value decomposition (SVD) based on a form of the Lanczos algorithm. At least for all synthetic problems that we have considered, the reliability, computational efficiency, and robustness of the methods presented here are as good as those obtained with quasi-Newton methods.

In a previous paper, we developed a theoretical basis for parameterization of reservoir model parameters based on truncated singular value decomposition (SVD) of the dimensionless sensitivity matrix. Two gradient-based algorithms based on truncated SVD were developed for history matching. In general, the best of these "SVD" algorithms requires on the order of 1/2 the number of equivalent reservoir simulation runs that are required by the limited memory BroydenFletcher-Goldfarb-Shanno (LBFGS) algorithm. In this work, we show that when combining SVD parameterization with the randomized maximum likelihood method, we can achieve significant additional computational savings by history matching all models simultaneously using a SVD parameterization based on a particular sensitivity matrix at each iteration. We present two new algorithms based on this idea, one which relies only on updating the SVD parameterization at each iteration and one which combines an inner iteration based on an adjoint gradient where during the inner iteration the truncated SVD parameterization does not vary. Results generated with our algorithms are compared with results obtained from the ensemble Kalman filter (EnKF). Finally, we show that by combining EnKF with the SVD-algorithm, we can improve the reliability of EnKF estimates.

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The technique of repair of postinfarction dyskinetic LVA should be adapted in each patient to the cavity size and extent of the scarring process into the septum and subvalvular mitral apparatus. Applying these considerations to the choice of the technique of repair, both techniques achieved satisfactory results with respect to perioperative mortality, late functional status and survival.

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