Kandungan Total Flavonoid Dari Ekstrak Metanol Akar Imperata cylindrical (L) Beauv. (Alang-alang)

Dhianawaty, Diah; Ruslin, Ruslin; Syamsunarno, Mas Rizky Anggun Adipurna; Haminah, Helmi

doi:10.32734/tm.v1i3.256

Cited by 6 publications

(6 citation statements)

References 9 publications

(10 reference statements)

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“…Dhianawaty measured the total flavonoid content by using aluminum chloride method, and the results showed that the extract contained flavonoids, with a total content of 1.17%. 32 Flavonoids consist of a large group of polyphenolic compounds having a benzo-ɤ-pyrone structure with many biological activities such as antioxidant, antibacterial, anti-inflammatory, antiviral, anticancer and hepatoprotection. 33 Several mechanisms have been proposed for the effect of flavonoids on the initiation and promotion stages of carcinogenesis, including the development and hormonal activities through downregulation of mutant p53 protein, cell cycle arrest, tyrosine kinase inhibition, inhibition of heat shock proteins, estrogen receptor binding capacity, and inhibition of expression of Ras proteins.…”

Section: Discussionmentioning

confidence: 99%

Quantification of total polyphenols and flavonoids, antioxidant activity, and Sinensetin and Imperatorin contents of Imperata cylindrica root ethanol extract

Indriyanti¹,

Ariyanto²,

Usman³

et al. 2022

Pharmacogn. J.

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Introduction: Imperata cylindrica, commonly known as cogon grass, is currently widely distributed and used as a medicinal plant. The major compounds that have been isolated and identified are polyphenols and flavonoids, which have many biological activities such as antioxidant, and anticancer. Polyphenols and flavonoids are mostly found in the roots and leaves. This study aimed to perform phytochemical screening on I. cylindrica root ethanol extract from Sragen, Central Java, Indonesia and determine the total polyphenol, flavonoid, antioxidant activity and quantify Sinensetin and Imperatorin contents of the extract. Method: Quantification of all parameters were measured using visible spectrophotometric methods. Total polyphenol, total flavonoid contents, as well as antioxidant activity were measured using Folin-Ciocalteu reagent, aluminum chloride reagent, and 1,1-diphenyl-2-picrylhydrazyl, respectively, and quantification of Sinensetin and Imperatorin were measured using High Performance Liquid Chromatography. Results: I cylindrica root ethanol extract had a total polyphenol content of 1.109% gallic acid equivalent, total flavonoid content of 0.1% quercetin equivalent, and antioxidant activity IC 50 824.30 µg/ml. Sinensetin and Imperatorin were also identified in Fractions 1 to 11 with concentrations of 0.0157 and 0.0178 mg/kg extract, respectively. Conclusion: I. cylindrica root ethanol extract from Sragen had active phytochemical compounds of polyphenols, flavonoids, and antioxidants as well as Sinensetin and Imperatorin.

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Section: Discussionmentioning

confidence: 99%

Quantification of total polyphenols and flavonoids, antioxidant activity, and Sinensetin and Imperatorin contents of Imperata cylindrica root ethanol extract

Indriyanti¹,

Ariyanto²,

Usman³

et al. 2022

Pharmacogn. J.

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“…Selain itu flavonoid memiliki aktivitas menginhibisi enzim ACE, sehingga menyebabkan terbentuknya kompleks khelat di pusat aktif ACE, dan bergantung pada fitur struktural utama dari senyawa flavonoid. Sehingga kandungan senyawa flavonoid dalam ekstrak serta aktivitasnya sebagai antioksidan membuktikan bahwa senyawa flavanoid tersebut memiliki kemampuan sebagai vasorelaxan [17].…”

Section: Hasil Uji Aktivitas Vasorelaxanunclassified

Standarisasi Parameter Spesifik Ekstrak Etanol Daun Jarak Pagar (Jatropha Curcas L) sebagai Vasorelaxan

Sadik,

Zulfian A. Disi

2023

JSSCR

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Jarak pagar (Jatropha curcas L.) is traditionally used as a medicinal plant and can be used scientifically to treat various diseases based on the scientific results of herbal medicine. This study aims to prove that the ethanol extract of Jarak pagar leaves (Jatropha curcas L.) meets the specific parameters for extract standardization. The ethanol extract of Jarak pagar (Jatropha curcas L.) leaves was obtained by maceration method, and then the extract was observed for specific parameters, which included an organoleptic test, identification of chemical content, determination of water-soluble juice content, and ethanol-soluble juice content, as well as other tests to see the activity of Jatropha curcas as a vasorelaxant using experimental methods. The results and data of specific parameter characteristics show that the extract made has met the requirements of Indonesian Medical Materials, which means that the ethanol extract of Jatropha curcas leaves made has met the standards, and based on activity testing, it is known that Jarak pagar leaves (Jatropha curcas L.) have the same activity as Vasorelaxan.

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“…Imperata cylindrica (hereinafter referred to as I. cylindrica) is a weed plant, in Indonesia it grows in over 8.5 million ha areas [1,2]. In traditional medicines it has positive roles for health, such as to treat wound and to prevent hypertension, tonic drink for health, urinary stones, fever, cough, etc [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

An Initial Study of Imperata Cylindrica Leaves Potential as Herbal Medicinal Ingredients

Dhianawaty

Ruslin

2022

Int J Curr Pharm Sci

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Objective: In traditional medicines, Imperata cylindrica (hereinafter referred to as I. cylindrica) roots are more frequently used than its leaves. The aim of this study was to determine three parameters, namely the content of total phenolic compounds, total flavonoid content, and antioxidant activity of I. cylindrica leaves and roots extracts. Then, root extract parameters were used as a comparison to evaluate the benefits of I. cylindrica leaves as herbal medicine. Methods: The total polyphenol content was measured by using the Folin-Ciocalteu method and total flavonoid content was measured by using aluminium chloride method due to measure the antioxidant activity using 1,1-diphenyl-method 2-pikrilhidrazil (DPPH) method. All methods used visible spectrophotometry. Results: The percentages of total phenolic content, total flavonoid content, and IC50 of antioxidant activity of I. cylindrica leaves extract were 8.1 % (GAE), 2.1% (QE) and 80 ppm, respectively. Then, the measurement results of I. cylindrica roots extract showed the percentages of total phenolic content, total flavonoid content, and IC50 of antioxidant activity were 1.13% (GAE), 0.28% (QE) and 368 ppm, respectively. Conclusion: The result showed that I. cylindrica leaves extract contained phenolic compounds and flavonoids and had antioxidant activity. The three phenolic compounds, flavonoids and antioxidant activity, have been shown to have effects on health. Therefore, the potential of I. cylindrica leaves utilization as herbal medicine can be promoted more widely.

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Kandungan Total Flavonoid Dari Ekstrak Metanol Akar Imperata cylindrical (L) Beauv. (Alang-alang)

Cited by 6 publications

References 9 publications

Quantification of total polyphenols and flavonoids, antioxidant activity, and Sinensetin and Imperatorin contents of Imperata cylindrica root ethanol extract

Quantification of total polyphenols and flavonoids, antioxidant activity, and Sinensetin and Imperatorin contents of Imperata cylindrica root ethanol extract

Standarisasi Parameter Spesifik Ekstrak Etanol Daun Jarak Pagar (Jatropha Curcas L) sebagai Vasorelaxan

An Initial Study of Imperata Cylindrica Leaves Potential as Herbal Medicinal Ingredients

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