Kampo for the Treatment of Pain in Japan: A Review

Arai, Young‐Chang P.; Makino, Izumi; Ikemoto, Tatsunori; Saisu, Hironori; Terajima, Yuki; Owari, Keiko

doi:10.1007/s40122-020-00160-w

Cited by 12 publications

(11 citation statements)

References 53 publications

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“…The development of plant-based medicines is performed especially in Asian countries, including Indonesia (19), Malaysia (20), Thailand (10,21), India (22), Korea (23), China (24), Japan (25,26), Iran (12,13,27), Turkey (11), Saudi Arabia (28), and Israel (17). in the countries mentioned above, herbal medicines have been used in traditional treatment for a long time.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review

Wahyuni

Sufiawati

Nittayananta

et al. 2021

J Herbmed Pharmacol

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Oral mucosal inflammation is one of the oral diseases causing pain and reducing the quality of human life. The types of oral mucosal inflammation that commonly found were recurrent aphthous stomatitis (RAS) and oral mucositis (OM). Anti-inflammatory drugs, both synthetic and plant-based, have been used to treat RAS and OM. Plant-based drugs have been attracted the attention of some researchers to minimize the side effects of synthetic drugs. However, a comprehensive review addressing the use of plant-based drugs for RAS and OM therapy, including drug formulation and species of plant, has not yet been reported. Here, we reported the article review of 9 publications derived from the databases of PubMed, ScienceDirect, Cochrane Library, and other additional relevant works, in order to find the effectiveness and safety of plant-based drugs for RAS and OM therapy. This review was written by following the PRISMA guidelines, and the risk of bias of the articles was evaluated using the Oxford Quality Scoring System. It was found that the effective and safe drugs for RAS therapy contained acemannan from Aloe vera and curcumin from Curcuma longa, both in an oral gel formulation. For OM therapy, drugs contained curcumin from Curcuma longa; licorice from Glycyrrhiza glabra; Aloe vera and black mulberry from Morus nigra, in soft tablet, mouthwash solution or mucoadhesive film formulation. In conclusion, the most effective and safest plant-based therapy for RAS is Acemannan 0.5% in oral gel, whereas for OM is Licorice root extract 0.18 mg in mucoadhesive film.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review

Wahyuni

Sufiawati

Nittayananta

et al. 2021

J Herbmed Pharmacol

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“…Extensive research shows that most herbal medicines have been used to manage pain with minimal or no side effects. [11][12][13][14][15] A previous evaluation reported that lipoic acid, curcumin phytosome and piperine are effective complementary therapy for complimenting conventional treatments to achieve better efficacy in reducing neuropathic pain. 16 A prospective clinical trial suggested that a Chinese herbal decoction (Xiaozhi decoction) effectively relieves postoperative pain and reduces analgesic medication after hemorrhoidectomy.…”

Section: Introductionmentioning

confidence: 99%

Global Research Trends of Herbal Medicine for Pain in Three Decades (1990–2019): A Bibliometric Analysis

Wang¹,

Meng²

2021

JPR

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Purpose The aim of this study was to explore the global research trends of herbal medicine for pain from 1990 to 2019, using bibliometric methods, and explore international collaborations, intellectual structure, the evolution of active topics, emerging trends, and research frontiers. Methods Articles on herbal medicine for pain were retrieved from WoSCC. Two information visualization softwares including CiteSpace and HistCite were used to process bibliographic catalogs. Identification of international collaborations, intellectual structure, the evolution of active topics, emerging trends, and research frontiers were performed based on results from bibliometric analysis. Results A total of 2986 original articles published between 1990 and 2019 were identified based on the inclusion criteria. The number of publications on herbal medicine for pain in WoSCC significantly increased. China ranked highest in the number of scientific outputs; however, articles with the highest citation rates were found to be from the United States. China–Japan reported the most active collaborations, whereas Kyung Hee University from South Korea was the most productive institution. Zhang Y was the most productive author, whereas research by Sherman KJ and Vane JR had the highest influence. Journal of Ethnopharmacology was the most active journal, whereas Integrative and Complementary Medicine was the most active research area. History of herbal medicine for pain research comprises three major phases of activities. The main points of focus of bibliometric analysis of herbal medicine for pain include “knee osteoarthritis”, “cancer”, “low back pain”, etc.. Moreover, research on mechanisms of action of herbal medicine for pain remains at the forefront of this field. Conclusion This paper provides a basis for future development of research on herbal medicine for pain, which may help researchers explore new directions for future research and identify new perspectives on potential collaborations in this field.

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“…Indeed, only 18 species among the 227 described contain over 10 plants ( Figure 1 ). However, the numbers of plants in polyherbal mixtures in Ayurveda ( Parasuraman et al, 2014 ), Kampo ( Arai et al, 2020 ), and traditional Chinese medicine ( Xutian et al, 2014 ) are not limited to 10. On the other hand, the species “Myrphasinum”, approved as officinal medicine in Russia, includes 12 plants ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Medical Species Used in Russia for the Management of Diabetes and Related Disorders

et al. 2021

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Background: Polyherbal mixtures called “medical species” are part of traditional and officinal medicine in Russia. This review aimed to analyze medical species used in Russia for the treatment of diabetes and related disorders. The information relevant to medical species, diabetes, and obesity was collected from local libraries, the online service E-library.ru, and Google Scholar. The prediction of the antidiabetic activity for the principal compounds identified in plants was performed using the free web resource PASS Online.Results: We collected and analyzed information about the compositions, specificities of use, and posology of 227 medical species. The medical species represent mixtures of 2–15 plants, while the most frequently mentioned in the literature are species comprising 3–6 plants. The top 10 plants among the 158 mentioned in the literature include Vaccinium myrtillus L., Phaseolus vulgaris L., Taraxacum campylodes G.E. Haglund., Urtica dioica L., Rosa spp., Hypericum spp., Galega officinalis L., Mentha × piperita L., Arctium spp, and Fragaria vesca L. The leading binary combination found in medical species comprises the leaves of V. myrtillus and pericarp of P. vulgaris; leaves of V. myrtillus and leaves of U. dioica; and leaves of V. myrtillus and aerial parts of G. officinalis. In triple combinations, in addition to the above-mentioned components, the roots of T. campylodes are often used. These combinations can be regarded as basic mixtures. Other plants are added to improve the efficacy, treat associated disorders, improve gastrointestinal function, prevent allergic reactions, etc. Meanwhile, an increase in plants in the mixture necessitates advanced techniques for quality control. A feature of medical species in Russia is the addition of fresh juices, birch sap, seaweeds, and adaptogenic plants. Modern studies of the mechanisms of action and predicted activities of the principal compounds from medicinal plants support the rationality of polyherbal mixtures. Nevertheless, the mechanisms are not well studied and reported due to the limited number of compounds. Further investigations with calculations of synergistic or additive indices are important for strengthening the scientific fundamentals for the wider use of medical species in the therapy of diabetes. Two medical species, “Arfazetin” (7 medicinal plants) and “Myrphasinum” (12 medicinal plants), are approved for use in officinal medicine. The efficacy of these species was confirmed in several in vivo experiments and clinical trials. According to modern regulatory rules, additional experiments and clinical trials are required for more detailed investigations of the mechanisms of action and confirmation of efficacy.Conclusion: We believe that the scientifically based utilization of rich plant resources and knowledge of Russian herbal medicine can significantly contribute to the local economy as well as to the sectors seeking natural healing products.

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Kampo for the Treatment of Pain in Japan: A Review

Cited by 12 publications

References 53 publications

Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review

Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review

Global Research Trends of Herbal Medicine for Pain in Three Decades (1990–2019): A Bibliometric Analysis

Medical Species Used in Russia for the Management of Diabetes and Related Disorders

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