Kaltes Atmosphärendruckplasma zur Behandlung akuter und chronischer Wunden

Emmert, Steffen; Welzen, A van; Masur, Kai; Gerling, Torsten; Bekeschus, Sander; Eschenburg, Christian; Wahl, P; Bernhardt, Thoralf; Schäfer, Mirijam; Semmler, María Eugenia Aubet; Grabow, Niels; Fischer, Tobias; Thiem, Alexander; Jung, Ole; Boeckmann, Lars

doi:10.1007/s00105-020-04696-y

Cited by 11 publications

(15 citation statements)

References 36 publications

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“…Clinical trials and case reports also revealed beneficial effects of plasma therapy on acute and chronic wounds, like diabetic foot wounds and pressure ulcers [32, 35–37]. Important in vivo studies on the efficacy of CAP in wound treatment as well as reviews were published very lately in 2020, which also nicely corroborate the results of our systematic review [38–40]. The effect of CAP on tissue regeneration has also been elucidated for its potential in scar treatment.…”

Section: Discussionsupporting

confidence: 74%

Cold atmospheric plasma applications in dermatology: A systematic review

Gan

Jiang

Duan

et al. 2020

Journal of Biophotonics

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Cold atmospheric plasma (CAP) applications can potentially lead to effective therapy for numerous skin diseases. Our aim is to systematically review the available data and map the use of CAP in dermatology. PubMed, Embase and Web of science were explored before 2020 for studies regarding the use of CAP in dermatology. A total of 166 studies were finally included. 74.1% of these studies used indirect CAP sources. Most studies used plasma jet (67.5%). Argon was the mostly used working gas (48.2%). Plasma application itself could be direct (89.2%) and indirect (16.3%). The proportion of studies with in vivo results remained 57.2%, of which most concerned direct plasma treatment (97.9%). Analyses performed indicate that CAP has been beneficial in many skin disorders. While, most CAP applications were focused on wound healing and melanoma treatment. This study provides a brief overview of CAP sources and relative medical applications in dermatology.

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Section: Discussionsupporting

confidence: 74%

Cold atmospheric plasma applications in dermatology: A systematic review

Gan

Jiang

Duan

et al. 2020

Journal of Biophotonics

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“…High mobility is part of the core requirement of the MSD’s development, as plasma wound treatment is becoming more relevant for ambulant patients [ 28 ]. To fulfill this requirement, MSD was developed with two different hardware versions in mind: as a standalone device and as an attachable module for tablets or laptops.…”

Section: Methodsmentioning

confidence: 99%

Development of a Mobile Sensory Device to Trace Treatment Conditions for Various Medical Plasma Source Devices

Siffa

Gerling²,

Masur³

et al. 2022

Sensors

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The emerging use of low-temperature plasma in medicine, especially in wound treatment, calls for a better way of documenting the treatment parameters. This paper describes the development of a mobile sensory device (referred to as MSD) that can be used during the treatment to ease the documentation of important parameters in a streamlined process. These parameters include the patient’s general information, plasma source device used in the treatment, plasma treatment time, ambient humidity and temperature. MSD was developed as a standalone Raspberry Pi-based version and attachable module version for laptops and tablets. Both versions feature a user-friendly GUI, temperature–humidity sensor, microphone, treatment report generation and export. For the logging of plasma treatment time, a sound-based plasma detection system was developed, initially for three medically certified plasma source devices: kINPen® MED, plasma care®, and PlasmaDerm® Flex. Experimental validation of the developed detection system shows accurate and reliable detection is achievable at 5 cm measurement distance in quiet and noisy environments for all devices. All in all, the developed tool is a first step to a more automated, integrated, and streamlined approach of plasma treatment documentation that can help prevent user variability.

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“…In the literature, two types of cold plasma treatment are generally considered: plasma jet and dielectric barrier discharge (DBD) [ 29 ]. In a plasma jet, the electrode (pin, ring, or plate type) is located in a capillary or tube inside a pen-like device, the plasma is generated inside the device, and the effluent is blown out along the gas flow through the tube and can directly contact with target.…”

Section: Application Of Cold Plasma Treatment In Biomedical Fieldsmentioning

confidence: 99%

“…These two types of cold plasma are generated inside small discharge gaps, consisting of transient micro discharges or filaments with non-uniform and constricted property [ 30 ]. CINOGY GmbH Plasma Derm DBD, AdtecSteriPlas ® DBD [ 31 ] and MED NTPJ [ 29 ] are IIa medical devices that have been certified by CE in Germany. Cold plasma technology has been extensively used in the fields of sterilization [ 18 , 32 ], blood coagulation [ 33 ], inactivated vaccine preparation [ 20 ], biofunctionalized materials [ 34 , 35 , 36 ], and oral treatment [ 4 ].…”

Section: Application Of Cold Plasma Treatment In Biomedical Fieldsmentioning

confidence: 99%

The Regulatory Mechanism of Cold Plasma in Relation to Cell Activity and Its Application in Biomedical and Animal Husbandry Practices

Zhang

et al. 2023

IJMS

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As an innovative technology in biological applications, cold plasma is widely used in oral treatment, tissue regeneration, wound healing, and cancer therapy, etc., because of the adjustable composition and temperature which allow the plasma to react with bio-objects safely. Reactive oxygen species (ROS) produced by cold plasma regulate cell activity in an intensity- and time-dependent manner. A low level of ROS produced by cold plasma treatment within the appropriate intensities and times promotes proliferation of skin-related cells and increases angiogenesis, which aid in the acceleration of the wound healing process, while a high level of ROS produced by cold plasma treatment performed at a high intensity or over a long period of time inhibits the proliferation of endothelial cells, keratinocytes, fibroblasts, and cancer cells. Moreover, cold plasma can regulate stem cell proliferation by changing niche interface and producing nitric oxide directly. However, the molecular mechanism of cold plasma regulating cell activity and its potential application in the field of animal husbandry remain unclear in the literature. Therefore, this paper reviews the effects and possible regulatory mechanisms of cold plasma on the activities of endothelial cells, keratinocytes, fibroblasts, stem cells, and cancer cells to provide a theoretical basis for the application of cold plasma to skin-wound healing and cancer therapy. In addition, cold plasma exposure at a high intensity or an extended time shows excellent performances in killing various microorganisms existing in the environment or on the surface of animal food, and preparing inactivated vaccines, while cold plasma treatment within the appropriate conditions improves chicken growth and reproductive capacity. This paper introduces the potential applications of cold plasma treatment in relation to animal-breeding environments, animal health, their growth and reproduction, and animal food processing and preservation, which are all beneficial to the practice of animal husbandry and guarantee good animal food safety results.

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Kaltes Atmosphärendruckplasma zur Behandlung akuter und chronischer Wunden

Cited by 11 publications

References 36 publications

Cold atmospheric plasma applications in dermatology: A systematic review

Cold atmospheric plasma applications in dermatology: A systematic review

Development of a Mobile Sensory Device to Trace Treatment Conditions for Various Medical Plasma Source Devices

The Regulatory Mechanism of Cold Plasma in Relation to Cell Activity and Its Application in Biomedical and Animal Husbandry Practices

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