Kallikreins expression in a mature cystic ovarian teratoma

T-SP1: a novel serine protease-like protein predominantly expressed in testis

“…Similarly, the human kallikrein-related peptidases, KLK2 and KLK13 (Lundwall et al, 2006), which show a sequence identity of 32% and 37%, respectively, with the catalytic domain of T-SP1/1, are highly expressed not only in testis but also in ovarian cancer tissues (Tremblay et al, 1996;Petraki et al, 2003;Scorilas et al, 2004;Dorn et al, 2007 (Yousef and Diamandis, 2003). Therefore, it seems possible that T-SP1 may also act as a marker of certain tumors, because we could show its protein expression in human ovarian cancer tissues as well as in glandular differentiated prostate carcinoma, where it may be upregulated by hormones.…”

Grossly visible prostatic tissue in an ovarian mature cystic teratoma: A case report

“…The teratoma is composed of well‐differentiated tissues originating from germ cell layers of the ectoderm, mesoderm, or endoderm, with predominant ectodermal components. Prostatic tissue in ovarian cystic teratomas is rare with only 21 cases reported in the literature 2–15 . Further, ectopic prostatic tissue has rarely been found in the uterine cervix and vagina, even with adrenogenital syndrome 16,17 .…”

“…Prostatic tissue has rarely been reported as a component of ovarian teratoma. To date, only 21 cases have been reported in the literature 2–15 …”

Prostate-specific antigen in the breast

“…There is also a case report of a patient with adenocarcinoma of the colon and highly elevated serum PSA levels which fell after surgery, presumably indicating PSA secretion by the tumour (Yamamoto & Miyake 1997). In addition there are reports of a cystic ovarian teratoma in which PSA was detected immunocytochemically (Tremblay et al 1996) and a primary ovarian carcinoma in which PSA expression was confirmed by immunoassay, immunohistochemistry, RT-PCR and sequencing of the PCR product (Yu et al 1995a).…”