Kallikrein-Kinin System Disbalance in Chronic Pancreatis in Combination With Metabolic Syndrome

Бабинец, Л. С.; Melnyk, N.; Shevchenko, Nataliia; Migenko, Bogdan O.; Zaets, Tetiana A.

doi:10.36740/wlek201911110

Cited by 4 publications

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“…With the development of ASBO, there is an increase in intra-abdominal pressure, which leads to the development of ischemic-reperfusion syndrome; there is an increase in reactive oxygen species and damage to cell membranes, which ultimately leads to necrosis. Activation of lipid peroxidation processes leads to an imbalance in the APS, which exacerbates the development of endogenous intoxication and enteral insufficiency syndromes [ 6 – 7 ]. Increasing the production of free radicals reduces the protective properties of the intestinal mucosa and facilitates bacterial translocation, naturally increasing the risk of failure of intestinal anastomoses.…”

Section: Disscusionmentioning

confidence: 99%

Changes of pro- and antioxidant indicators in experimental animals under acute small bowel obstructions

et al. 2021

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Acute small bowel obstruction remains one of the most challenging nosologies in emergency surgery, leading to a pronounced imbalance between lipid peroxidation and the antioxidant defense system. We aimed to study changes in the anti- and prooxidant status of serum and small intestine wall in an experiment modeling acute small bowel obstruction. The control group included 11 rats, and the main group included 42 rats (simulation of mechanical bowel obstruction on day 1 was conducted in 14 rats, on day 2 – in 12 rats, on day 3 – in 16 rats). Acute small bowel obstruction was modeled by ligation. Serum analysis and removal of the small intestinal wall were performed on days 1, 2, and 3. Indicators of lipid peroxidation and antioxidant protection were determined by the spectrophotometric method, and the imbalance between lipid peroxidation and antioxidant protection gradually increased from 1 to 3 days of observation. On day 3, the low level of aldehyde increased 1.3 times, and the level of superoxide dismutase decreased 1.2 times compared to the control group. Pathophysiological changes in the wall of the small intestine are caused by the activation of lipid peroxidation and the exhaustion antioxidant protection, whereby the degree of their severity increases depending on the increase in time from the moment of modeling of acute obstruction of the small intestine.

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Section: Disscusionmentioning

confidence: 99%

Changes of pro- and antioxidant indicators in experimental animals under acute small bowel obstructions

et al. 2021

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“…М етаболічний синдром (МС), або «синдром інсулінорезистентності», -це група загальних порушень, зокрема резистентність до інсуліну, порушення толерантності до глюкози, абдомінальне ожиріння, зниження рівня ліпопротеїдів високої щільності (ЛПВЩ), підвищення рівня тригліцеридів і артеріальна гіпертензія [1][2][3]. Загальна причина цих порушень на сьогодні невідома.…”

Section: Comparative Analysis Of the Quality Of Life Scales Parameter...unclassified

Comparative Analysis of the Quality of Life Scales Parameters in Patients with Combination of Stable Ischemic Heart Disease and Metabolic Syndrome

Liliia

Melnyk

2021

FMEP

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Modern epidemiological studies confirm that comorbid diseases and conditions can have significant impact on diagnostic and treatment of the underlying disease. The problem of the comorbidy of stable coronary heart disease (SCHD) and metabolic syndrome (MS) has high medical and social significance, need high costs for diagnosis and treatment, and leads to decreased of quality of life (QOL). QOL is an important indicator of the health status of patients, which comprehensively characterizes human physical, psychological, emotional and social functioning. The objective: to conduct a comparative analysis of the QOL of patients with combination of SCAD and MS versus patients with isolated SCHD. Materials and methods. The study included 102 patients: 52 people with MS in combination with SCAD and 50 patients with SCHD only. There were 42 (51.2%) men (mean age 49.8 ± 5.3 years), and 40 (48.8%) women (mean age 51.6 ± 6.7 years). The QoL score was assessed by general medical questionnaire – the Medical Outcomes Study 36-Item (SF-36), in which all scales form two indicators: mental and physical health and a specialized questionnaire for patient with stable angina pectoris – SAQ (Seattle Angina Questionnaire). The diagnosis of SCHD with functional class (FC) assessment was performed by European Society of Cardiology criteria. MS was established if three out of five diagnostic criteria were met. Results. Patients with comorbid MS and SCHD demonstrated significantly lower QoL scores, both in psychological and physical components of health (according to the SF-36 questionnaire) compared to patients with SCHD alone (p <0.05). An analysis of the SAQ questionnaire data also showed significantly lower points in group of patients with NAS and SCHD combination compared to the group of patients with isolated SCHD (in total, by 8.76%; p <0.05). Conclusion. Patients with metabolic syndrome in combination with stable coronary heart disease (SCHD) had a statistically significantly lower level of quality of life according to the evaluation by both SF-36 nonspecific questionnaire and the SAQ specific questionnaire comparing to group of patients with isolated SCAD.

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“…У вагу науковців все частіше привертають проблеми ураження органів травлення при метаболічному синдромі (МС) [7,15]. Цей науковий напрямок є важливим і актуальним, оскільки зміни печінки та підшлункової залози (ПЗ), характерні для МС, спричинюють прогресування цього симптомокомплексу і розвиток низки ускладнень [2,7,21].…”

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“…Основною ланкою формування МС є інсулінорезистентність (ІР), яку вважають прогностичним чинником розвитку низки захворювань (ішемічної хвороби серця, цукрового діабету, артеріальної гіпертензії), а також незалежним фактором розвитку атеросклерозу [2,4,12,15,16]. У багатьох випадках пусковим моментом виникнення ІР слугує надмірна маса тіла [13].…”

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“…Коморбідні патології створюють труднощі у встановленні діагнозу та виборі тактики лікування, значно погіршують якість життя хворого [1,2]. Важливою клініко-соціальною проблемою є необхідність удосконалення методів діагностики і лікування захворювань, асоційованих із МС, оскільки призводять до ранньої інвалідизації і високої смертності [4,7,20,21].…”

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Comparative Analysis of the Structure and Function of the Pancreas in Patients with a Combination of Chronic Pancreatitis and Metabolic Syndrome

Babinets,

Kytsai

2023

FMEP

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Metabolic syndrome (MS) is the most urgent problem of modern medicine, which is associated with an unhealthy lifestyle. This is a complex metabolic disorder based on insulin resistance and compensatory hyperinsulinemia. MS is a risk factor for the development of a significant number of various diseases. The objective: to determine the structural and functional state of the liver and pancreatic gland (PG) in patients with chronic pancreatitis (CP) depending on the presence of MS. Materials and methods. 137 patients with CP of biliary genesis (CBP) were included in the study. Patients were divided into two groups: the 1st group – 22 persons with isolated CBP, the 2nd group – 115 patients with CBP+MS. The control group included 20 practically healthy subjects. The age of the study participants ranged from 30 to 71 years. The presence of MS was determined, the state and structure of the PG and liver were examined. Results. A statistically significant higher content of HbA1c was determined in patients with CBP and MS compared to the group of patients with only CBP (6.10±0.14% vs. 5.47±0.15%). A significantly higher blood glucose level was found in the patients with CBP+MS (5.99±0.29 mmol/l vs. 5.31±0.12 mmol/l) compared to patients with CBP. A significantly higher level of the HOMA index was also determined in the group of patients with CBP+MS compared to the CBP group (2.60±0.10 vs.1.84±0.09). A higher level of liver stiffness was found in patients with CBP compared to the control group. The indicator of fecal α-elastase in patients with CBP+MS was 114.52±2.79 mcg/g, which was significantly lower than that in the group of patients with CBP without MS (158.60±5.55 mcg/g). Conclusions. In the presence of MS in patients with chronic biliary pancreatitis, more significant structural disorders in the liver and pancreas were established in the direction of increased density according to shear wave elastometry. The results of the study demonstrated the aggravating effect of concomitant MS on the structural state of the liver and on the structural and functional state of the pancreas in patients with chronic biliary pancreatitis.

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Kallikrein-Kinin System Disbalance in Chronic Pancreatis in Combination With Metabolic Syndrome

Cited by 4 publications

References 0 publications

Changes of pro- and antioxidant indicators in experimental animals under acute small bowel obstructions

Changes of pro- and antioxidant indicators in experimental animals under acute small bowel obstructions

Comparative Analysis of the Quality of Life Scales Parameters in Patients with Combination of Stable Ischemic Heart Disease and Metabolic Syndrome

Comparative Analysis of the Structure and Function of the Pancreas in Patients with a Combination of Chronic Pancreatitis and Metabolic Syndrome

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