Kakadu plum fruit extracts inhibit growth of the bacterial triggers of rheumatoid arthritis: Identification of stilbene and tannin components

Sirdaarta, Joseph; Matthews, Ben; Cock, Ian Edwin

doi:10.1016/j.jff.2015.06.019

Cited by 84 publications

(108 citation statements)

References 33 publications

(41 reference statements)

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“…Many high antioxidant fruits and herbs have been reported to have good antibacterial activities. [12][13][14][15][16][17][18][19]21,33,36 Given the high antioxidant capacities and 'superfood' status of acai, cacao and maca, surprisingly few studies have examined their ability to inhibit the growth of pathogenic bacteria. Indeed, whilst multiple anecdotal reports are available, we were unable to find any scientific studies screening acai, cacao or maca extracts for the ability to inhibit the growth of P. mirabilis, K. pneumoniae, A. baylyi or P. aeruginosa.…”

Section: Discussionmentioning

confidence: 99%

“…18 Particularly noteworthy, Terminalia ferdinandiana (Kakadu plum), Tasmannia lanceolata (mountain pepperberry) and several Syzygium spp. (which are often referred to as 'superfoods' due to their extremely high antioxidant capacities) are potent growth inhibitors of microbial triggers of rheumatoid arthritis (Proteus mirabilis), 19 ankylosing spondylitis (Klebsiella pneumoniae) 20 and multiple sclerosis (Acinetobacter baylyi and Pseudomonas aeruginosa). 21 Therefore these plants have potential in the prevention and treatment of autoimmune inflammatory diseases in genetically susceptible individuals.…”

Section: Introductionmentioning

confidence: 99%

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Acai, cacao and maca extracts: Anticancer activity and growth inhibition of microbial triggers of selected autoimmune inflammatory diseases

Wang¹,

Zhang²,

Cock³

2016

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Background: The consumption of high antioxidant foods has been linked with a decreased incidence of some cancers and inflammatory diseases. Some high antioxidant foods also inhibit the growth of a variety of bacterial pathogens. Despite this, the high antioxidant 'superfoods' acai, cacao and maca are yet to be adequately tested for anticancer activity or the ability to inhibit the growth of bacterial triggers of autoimmune inflammatory diseases. Materials and Methods: Freeze dried acai, cacao and maca powders were extracted and tested for antimicrobial activity using a modified disc diffusion assay and the MICs were determined. Inhibitory activity against CaCo2 and HeLa cancer cell lines was evaluated using colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. Results: The acai, cacao and maca extracts displayed broad spectrum antibacterial activity, inhibiting the growth of all of the bacteria screened, although generally with only low efficacy. The ethyl acetate extracts were more potent bacterial growth inhibitors than were the corresponding methanolic and aqueous extracts. The inhibitory activity of the acai and maca ethyl acetate extracts against P. mirabilis was particularly noteworthy, with MIC values <1000 µg/mL. The aqueous and methanolic extracts of all fruits had only low bacterial growth inhibitory activity. In contrast, the aqueous extracts of cacao and maca were the most effective at inhibiting proliferation of the colorectal cancer cell line CaCo2 (aqueous maca extract IC 50 =1800 µg/mL) and HeLa cervical cancer cell growth, (aqueous cacao extract IC 50 values 1810 µg/mL). All extracts were non-toxic, with LC 50 values substantially > 1000 µg/mL. Conclusion: These studies demonstrate that the aqueous cacao and maca extracts have appreciable inhibitory activity against some cancer cell lines and that the acai and maca ethyl acetate extracts were moderate inhibitors of the growth of bacteria associated with selected autoimmune inflammatory disorders. Furthermore, the toxicity studies indicate that they are safe for therapeutic usage. All other extracts were inactive or of low activity towards the cancer and bacterial cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acai, cacao and maca extracts: Anticancer activity and growth inhibition of microbial triggers of selected autoimmune inflammatory diseases

Wang¹,

Zhang²,

Cock³

2016

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“…6 Whilst numerous therapeutic properties are known for Terminalia spp., the antibacterial activity has been particularly well reported. Extracts prepared from the fruit of the Australian species Terminalia ferdinandiana (Kakadu plum) have potent growth inhibitory activity against an extensive panel of pathogens including bacteria associated diarrhoea and dysentery 7 as well as the bacterial triggers of rheumatoid arthritis (Proteus mirabilis) 8 and multiple sclerosis (Acinetobacter baylyi and Pseudomonas aeruginosa). 7 Leaf extracts from the same species have also been shown to inhibit growth of the same bacteria, as well as a microbial trigger of ankylosing spondylitis (Klebsiella pneumoniae).…”

Section: Introductionmentioning

confidence: 99%

“…7 Leaf extracts from the same species have also been shown to inhibit growth of the same bacteria, as well as a microbial trigger of ankylosing spondylitis (Klebsiella pneumoniae). 8 Recent studies have demonstrated the growth inhibitory activity of Terminalia sericea and Terminalia prunioides against pathogenic [10][11][12] and food spoilage bacteria. 13 The Indian Terminalia spp.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Pharmacognostic Potential of Indian Terminalia Spp. in the Treatment and Prevention of Yersiniosis

Wright¹,

Greene²,

Cock³

2017

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Introduction: Yersinia enterocolitica is a major cause of food poisoning through contaminated meat products, causing the acute gastrointestinal disease yersiniosis. Many Terminalia spp. have documented therapeutic properties as general antiseptics, inhibiting the growth of a wide variety of bacterial species. Despite this, Indian Terminalia spp. extracts have not been tested for the ability to inhibit the growth of Y. enterocolitica. Methods: T. arjuna, T. catappa and T. chebula extracts were extracted by maceration and the extracts were investigated by disc diffusion assay for growth inhibitory activity against a clinical strain of Y. enterocolitica. The MIC values of the extracts were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: T. chebula fruit extracts displayed potent growth inhibitory activity in the disc diffusion assay against Y. enterocolitica. The methanolic and ethyl acetate T. chebula fruit extracts were particularly potent growth inhibitors, with MIC values of 85 and 64 µg/mL respectively. The aqueous fruit extract also displayed good growth inhibitory activity against Y. enterocolitica, albeit with a higher MIC value (653 µg/mL). The T. arjuna branch extract was moderately active (3000 µg/mL). All other extracts were either low efficacy, or completely devoid of growth inhibitory activity. All Indian Terminalia spp. extracts were nontoxic (LC 50 values <1000 µg/mL) in the Artemia franciscana bioassay. Conclusions: The lack of toxicity and the potent growth inhibitory bioactivity of the T. chebula extracts against Y. enterocolitica indicates their potential as medicinal agents in the treatment and prevention of yersiniosis.

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“…20 Furthermore, recent studies have also reported antibacterial activity in extracts from high antioxidant Australian plants. [21][22][23][24] Particularly noteworthy, the Australian species S. australe (Bush Cherry) and S. luehmannii (Riberry) have potent growth inhibitory activity against a broad panel of bacteria. 25,26 However, despite the reported broad spectrum growth inhibitory activity of Australian Syzygium spp., numerous pathogens are yet to be evaluated for their susceptibility to Australian Syzygium spp.…”

Section: Introductionmentioning

confidence: 99%

Growth Inhibitory Activity of Selected High Antioxidant Australian Syzygium Species Against the Food Poisoning and Tissue Necrotic Pathogen Clostridium Perfringens

Wright¹,

Lee²,

Pollock³

et al. 2016

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Introduction: Clostridium perfringens is a gram positive pathogen which is an etiological agent in Clostridial myonecrosis and enteritis necroticans. Unless promptly treated, C. perfringens infections may result in tissue necrosis and death. Syzygium australe (brush cherry) and Syzygium luehmannii (riberry) fruit and leaves have documented therapeutic properties as general antiseptic agents against an extensive panel of bacteria. Despite this, studies are yet to test the growth inhibitory activity of these species against C. perfringens. Methods: S. australe and S. luehmannii fruit and leaf extracts were investigated by disc diffusion assay for growth inhibitory activity against a clinical strain of Clostridium perfringens. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: Methanolic and aqueous S. australe and S. luehmannii fruit and leaf extracts as well as the corresponding fruit ethyl acetate extracts, displayed growth inhibitory activity in the disc diffusion assay against C. perfringens. The aqueous and methanolic extracts were particularly potent growth inhibitors, each with MIC values substantially <500 µg/mL. The S. australe fruit extracts were nontoxic in the Artemia franciscana bioassay (LC 50 values <1000 µg/mL). All ethyl acetate extracts were also nontoxic. In contrast, the S. luehmannii aqueous and methanolic extracts (fruit and leaf), as well as the S. australe leaf extracts displayed substantial toxicity in the assay. Conclusion: The potent growth inhibitory bioactivity of the fruit and leaf aqueous and methanolic Syzygium spp. extracts against C. perfringens indicates their potential as medicinal agents in the treatment and prevention of clostridial myonecrosis and enteritis necroticans.

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Kakadu plum fruit extracts inhibit growth of the bacterial triggers of rheumatoid arthritis: Identification of stilbene and tannin components

Cited by 84 publications

References 33 publications

Acai, cacao and maca extracts: Anticancer activity and growth inhibition of microbial triggers of selected autoimmune inflammatory diseases

Acai, cacao and maca extracts: Anticancer activity and growth inhibition of microbial triggers of selected autoimmune inflammatory diseases

Investigating the Pharmacognostic Potential of Indian Terminalia Spp. in the Treatment and Prevention of Yersiniosis

Growth Inhibitory Activity of Selected High Antioxidant Australian Syzygium Species Against the Food Poisoning and Tissue Necrotic Pathogen Clostridium Perfringens

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