Kajian Peran Gen P53 dalam Tumorigenesis

Abstract

Gene p53 is a tumor suppressor gene that in normal conditions is in ' standby ' mode , several studies show that pivotal point that lead to stimulation of p53 is DNA damage , heat shock , hypoxia, exposure of nitric oxide ( NO ) , the expression of oncogenes and some p53 pathways activation. p53 mechanism as a guardian of genome stability are cell cycle arrest, repair of DNA damaged, induce apoptosis, prevents angiogenesis , invasion and metastasis ability of the tumor. On many tumor , p53 is not loss , but mutated , the p53 mutant was expressed 70 % in lung cancer , and in different frequencies in other cancers . Then the role of p53 as a transcription factor that works to regulate genes involved in tumor suppression is indispensable .

Exercise as a method to reduce the risk of oral cancer: A narrative review

“…18 cells can be repaired. 22,23 If DNA damage is extensive and irreversible, p53 can initiate apoptosis. Additionally, p53 stimulates cytochrome-c from mitochondria by activating apoptotic genes, e.g.…”

“…Cytochrome-c triggers caspases, which subsequently activate deoxyribonuclease (DNase), an enzyme which penetrates the cell nuclear membrane and damages DNA, causing cell death. 22,24 Therefore, cells with mutations in the p53 gene can turn into cancerous cells.…”