Kainic acid-induced thalamic seizure in cats — a possible model of petit mal seizure

Araki, Takehisa; Tanaka, Tatsuya; Tanaka, Shigeya; Yonemasu, Yukichi; Kato, Motohiro; Goto, Ikuo

doi:10.1016/0920-1211(92)90056-y

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…When kainic acid (KA) was infused into the limbic system, thalamus or neocortex in rats and cats, focal seizures were induced initially, which then developed into secondarily generalized seizures [6][7][8][9][10]. In these studies of KA-induced seizures, evidence disclosed that the MRF influenced secondary generalization of focal seizures.…”

Section: Introductionmentioning

confidence: 93%

Generalized Seizures Induced by an Epileptic Focus in the Mesencephalic Reticular Formation: Impact on the Understanding of the Generalizing Mechanism

Hashizume

Tanaka²,

Fujita³

et al. 2000

Stereotact Funct Neurosurg

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The mode of seizure propagation was studied using a generalized seizure model induced by microinjection of kainic acid (KA) into a unilateral mesencephalic reticular formation (MRF) in cats and rats. Stereotactic surgery was performed under pentobarbital anesthesia; an injection cannula was placed into a unilateral MRF, and bipolar electrodes were implanted into the MRF and the thalamus. Microinjection of KA induced generalized seizures. Focal electrical seizures were elicited in the injected site of the MRF starting 30 min after the injection. The initial clinical change during each seizure was behavioral arrest. These seizures immediately developed to generalized seizures, which were characterized by generalized tonic convulsions with short-term clonic convulsions. On EEG, each generalized seizure started at the same time in all the sites of the brain recorded. Autoradiographic study using a rat model demonstrated high glucose utilization in the MRF, bilateral thalamus, forebrain and bilateral cerebral cortices. The results demonstrated an active participation of MRF in the mechanism of generalized seizures.

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Section: Introductionmentioning

confidence: 93%

Generalized Seizures Induced by an Epileptic Focus in the Mesencephalic Reticular Formation: Impact on the Understanding of the Generalizing Mechanism

Hashizume

Tanaka²,

Fujita³

et al. 2000

Stereotact Funct Neurosurg

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“…The corticothalamocortical circuits mediate the generation of neural oscillations, and the abnormal hypersynchronized oscillations in the thalamocortical (TC) network, consisting of positive and negative feedback connections between the cortex and the thalamus, have been implicated as an underlying mechanism for the generation of the spike-wave discharges (SWDs), which is a characteristic of the absence epilepsy. It has been demonstrated that stimulation of the midline thalamic structures or microinjection of neuron analeptics to the ventrobasal thalamus elicited EEG responses in the cortex very similar to the SWDs of the generalized absence epilepsy [ 31 , 32 ]. Recent evidence revealed that the phospholipase C beta4 (PLC β 4) pathway tunes the firing mode of TC neurons via the simultaneous regulation of T- and L-type Ca(2+) currents as PLC β 4-deficient TC neurons were readily shifted to the oscillatory burst firing mode after a slight hyperpolarization of membrane potential.…”

Section: Thalamus Is the Convergent Pivot For Epileptogenesis Acumentioning

confidence: 99%

Acupuncture for Refractory Epilepsy: Role of Thalamus

Chen

Wang

Rong

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Neurostimulation procedures like vagus nerve stimulation (VNS) and deep brain stimulation have been used to treat refractory epilepsy and other neurological disorders. While holding promise, they are invasive interventions with serious complications and adverse effects. Moreover, their efficacies are modest with less seizure free. Acupuncture is a simple, safe, and effective traditional healing modality for a wide range of diseases including pain and epilepsy. Thalamus takes critical role in sensory transmission and is highly involved in epilepsy genesis particularly the absence epilepsy. Considering thalamus serves as a convergent structure for both acupuncture and VNS and the thalamic neuronal activities can be modulated by acupuncture, we propose that acupuncture could be a promising therapy or at least a screening tool to select suitable candidates for those invasive modalities in the management of refractory epilepsy.

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Feline Temporallappenepilepsie – Was lernen wir von unseren Katzen?

Matiasek

Rosati

2017

Z. Epileptol.

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Kainic acid-induced thalamic seizure in cats — a possible model of petit mal seizure

Cited by 6 publications

References 22 publications

Generalized Seizures Induced by an Epileptic Focus in the Mesencephalic Reticular Formation: Impact on the Understanding of the Generalizing Mechanism

Generalized Seizures Induced by an Epileptic Focus in the Mesencephalic Reticular Formation: Impact on the Understanding of the Generalizing Mechanism

Acupuncture for Refractory Epilepsy: Role of Thalamus

Feline Temporallappenepilepsie – Was lernen wir von unseren Katzen?

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