KAI1 COOH‐terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer

Lee, Joon Kyoo; Yoon, Tae Mi; Seo, Deok Jung; Sun, Eun Gene; Bae, Jeong A; Lim, Sang Chul; Choi, Yoo Duk; Lee, Jae Hyuk; Joο, Young Eun; Kim, Kyung Keun

doi:10.1002/lary.20864

Cited by 10 publications

(11 citation statements)

References 17 publications

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“…Recently, high KITENIN was significantly associated with advanced stage, tumor extent, and lymph node metastasis in human laryngeal cancer. However, there was no difference in the overall survival and disease‐free survival between the low‐ and high‐KITENIN expression groups among patients with laryngeal cancer 20 . Finally, we examined the relationship between expression of KITENIN and various clinicopathological parameters and survival in human colorectal cancer patients.…”

Section: Discussionmentioning

confidence: 95%

“…In bladder cancer cell lines, KITENIN‐positive cancer cells with loss of KAI1/CD82 were associated with increased in vitro invasive ability 19 . High KITENIN expression was significantly associated with advanced stage, tumor extent, and lymph node metastasis in human laryngeal cancer 20 . Collectively, these studies suggest that KITENIN expression may be useful as a molecular marker for the prediction of cancer progression and specific knockdown of KITENIN may be useful as the anti‐metastatic cancer gene therapy.…”

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confidence: 85%

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Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression

Lee¹,

Song²,

Park³

et al. 2011

Pathology International

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KAI1 COOH-terminal interacting tetraspanin (KITENIN) contributes to tumor invasion and metastasis in various cancers. The aim of current study was to evaluate whether KITENIN affects tumor cell invasion and prognosis in human colorectal cancers. We investigated the biologic role of KITENIN on tumor cell invasion by using small interfering RNA in Caco2, DLD1, and SW480. We evaluated the expression of KITENIN and activator protein-1 (AP-1) target genes in human colorectal cancer tissues. The tumor cell invasion was decreased by knockdown of KITENIN in three tested cell lines. The mRNA expression of cyclin D1 and COX-2 was decreased in KITENIN knockdown Caco2 and the mRNA expression of MMP-3 and COX-2 was decreased in KITENIN knockdown DLD1 and SW480. The extracellular-signal protein kinase 1/2 (ERK1/2) phosphorylation was decreased in KITENIN knockdown in three tested cell lines. Expression of KITENIN and AP-1 target genes was significantly increased in human colorectal cancer tissues. The ERK1/2, c-Jun N-terminal kinase (JNK) and p38 phosphorylations were increased in human colorectal cancer tissues. Expression of KITENIN was significantly associated with lymphovascular invasion, depth of invasion, lymph node metastasis, tumor stage and poor survival. These results indicate that KITENIN is associated with human colorectal cancer progression including invasion and metastasis.

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Section: Discussionmentioning

confidence: 95%

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confidence: 85%

Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression

Lee¹,

Song²,

Park³

et al. 2011

Pathology International

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“…Variant isoforms of CD44 are expressed in HNSCC 18,19. It was recently reported that KITENIN is highly expressed in tumors and metastatic lymph nodes compared with adjacent mucosa and non-metastatic lymph nodes in head and neck cancer,20 that it is highly expressed in advanced laryngeal cancer compared with early laryngeal cancer,21 and that it represents a more aggressive phenotype in an HNSCC model 22. It is possible that we could characterize the CNUH-HNSCC-1 cell line by use of these markers and apply them to in vivo experiments.…”

Section: Discussionmentioning

confidence: 99%

Establishment of a Cell Line (CNUH-HNSCC-1) Derived from an Advanced Laryngeal Squamous Cell Carcinoma

Lee

2011

Chonnam Med J

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Cancer cell lines are the basic material for various lines of cancer research. Diverse cancer cell lines derived from tissues of various head and neck regions are needed for biological research on head and neck cancer. However, cell lines derived from cancer of the head and neck are not common. Recently, we established and characterized a novel human squamous carcinoma cell line, CNUH-HNSCC-1. From six cases of head and neck cancer, we established one specimen that was maintained for over 50 passages. We characterized the cell line as follows: growth patterns and curve, morphology by use of phase-contrast microscopy, and tumorigenicity by implanting the cell line into nude mice and making morphological comparisons. CNUH-HNSCC-1 cells grew well in vitro even after passage 50. However, the cells failed to form tumors in nude mice. CNUH-HNSCC-1 cells could be used as a control cell line for studying the biology of head and neck cancer.

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“…KITENIN protein expression is significantly higher in human colon (11,12), laryngeal (14), oral cavity squamous (15), gastric (16), and hepatocellular (17) cancer tissues than in corresponding normal mucosa or early-stage cancer tissues. Interaction of KITENIN with Dishevelled (Dvl)/PKCd is important in regulating colorectal cancer cell invasion via ERK/AP-1 activation (11) and expression of KITENIN is significantly associated with lymph node metastasis and poor survival of colorectal cancer (12).…”

Section: Introductionmentioning

confidence: 99%

“…Previously, we identified KAI1 C-terminal interacting tetraspanin (KITENIN) as a metastasis-enhancing gene (9,10) that participates in the dissemination of colorectal (11,12), squamous (13)(14)(15), gastric (16), and hepatocellular cancer cells (17). KITENIN protein expression is significantly higher in human colon (11,12), laryngeal (14), oral cavity squamous (15), gastric (16), and hepatocellular (17) cancer tissues than in corresponding normal mucosa or early-stage cancer tissues.…”

Section: Introductionmentioning

confidence: 99%

An Unconventional KITENIN/ErbB4-Mediated Downstream Signal of EGF Upregulates c-Jun and the Invasiveness of Colorectal Cancer Cells

Bae¹,

Yoon²,

Park³

et al. 2014

Clinical Cancer Research

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Purpose: EGF-stimulated signaling via EGF receptor (EGFR) is important in colorectal tumorigenesis and drug targeting. However, anti-EGFR therapy is not effective in a subset of patients with colorectal cancer, suggesting that unidentified EGF-stimulated pathways might play roles in colorectal cancer. Previously, we identified KAI1 C-terminal interacting tetraspanin (KITENIN) as a metastasis-enhancing gene and found it to be highly expressed in sporadic colorectal cancer tissues. We recently found that EGF further increases KITENIN-induced elevated AP-1 activity. Here we attempted to clarify this novel EGF-stimulated molecular pathway and its roles in colorectal cancer.Experimental Design: We analyzed how EGF modulates the downstream signaling pathway of oncogenic KITENIN in colorectal cancer cells. Biological alterations following EGF treatment were identified in KITENIN-overexpressed colorectal cancer cells with or without alteration of EGFR activity.Results: We identified the KITENIN/ErbB4-Dvl2-c-Jun axis as a novel downstream signal of EGF that is switched on under elevated KITENIN conditions in an EGFR-independent manner. This unconventional EGF signal upregulates c-Jun and enhances invasion and anchorage-independent growth of colorectal cancer cells. In addition, tumor tissues from metastatic patients with colorectal cancer who showed initial poor responses to cetuximab/chemotherapy expressed higher levels of KITENIN than did responders to therapy.Conclusions: Our results highlight the role of an EGFR-independent EGF signal in mediating the invasiveness and tumorigenesis of colorectal cancer cells. This unconventional pathway might be related to the limited clinical efficacy of anti-EGFR agents in a subset of patients with colorectal cancer. Clin Cancer Res; 20(15); 4115-28. Ó2014 AACR.

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KAI1 COOH‐terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer

Cited by 10 publications

References 17 publications

Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression

Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression

Establishment of a Cell Line (CNUH-HNSCC-1) Derived from an Advanced Laryngeal Squamous Cell Carcinoma

An Unconventional KITENIN/ErbB4-Mediated Downstream Signal of EGF Upregulates c-Jun and the Invasiveness of Colorectal Cancer Cells

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