Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1

BinMowyna, Mona N.; AlFaris, Nora A.

doi:10.1080/13880209.2021.1877734

Cited by 52 publications

(39 citation statements)

References 51 publications

(121 reference statements)

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“…Kaempferol reduces liver damage in acetaminophen-treated rats by upregulating silent information regulator 1 (SIRT1). It suppresses the acetylation of all SIRT1 targets, including PARP1, p53, NF-jB, FOXO-1, and p53 that mediate antioxidant, anti-inflammatory, and anti-apoptotic effects [ 81 ]. It also showed a hepatoprotective effect in alcohol-induced liver injury in mice by suppressing the expression of key microsomal enzyme cytochrome 2E1 (Cyp2E1) and by enhancing the protective role of the antioxidative defense system [ 82 ].…”

Section: Antioxidant Potential Of Kaempferol In Preventing Hccmentioning

confidence: 99%

Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma

et al. 2021

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Reactive oxygen species (ROS) are noxious to cells because their increased level interacts with the body’s defense mechanism. These species also cause mutations and uncontrolled cell division, resulting in oxidative stress (OS). Prolonged oxidative stress is responsible for incorrect protein folding in the endoplasmic reticulum (ER), causing a stressful condition, ER stress. These cellular stresses (oxidative stress and ER stress) are well-recognized biological factors that play a prominent role in the progression of hepatocellular carcinoma (HCC). HCC is a critical global health problem and the third leading cause of cancer-related mortality. The application of anti-oxidants from herbal sources significantly reduces oxidative stress. Kaempferol (KP) is a naturally occurring, aglycone dietary flavonoid that is present in various plants (Crocus sativus, Coccinia grandis, Euphorbia pekinensis, varieties of Aloe vera, etc.) It is capable of interacting with pleiotropic proteins of the human body. Efforts are in progress to develop KP as a potential candidate to prevent HCC with no adverse effects. This review emphasizes the molecular mechanism of KP for treating HCC, targeting oxidative stress.

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Section: Antioxidant Potential Of Kaempferol In Preventing Hccmentioning

confidence: 99%

Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma

et al. 2021

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“…SIRT1 also is closely associated with the mammalian forkhead transcription proteins [24,55,[193][194][195][196][197]. The induction of autophagy relies upon mammalian FOXO proteins of the O class that have an important relationship to neurodegenerative disorders [40,162,187,198,199].…”

Section: Circadian Clock Genes and The Silent Mating Type Information Regulation 2 Homolog 1 (Saccharomyces Cerevisiae) (Sirt1)mentioning

confidence: 99%

“…In regard to SIRT1, SIRT1 activity leads to increased survival through inhibition of FoxO activity [5,14,[194][195][196]. Yet, FoxOs also can bind to the SIRT1 promoter region to alter forkhead transcription [206].…”

Section: Circadian Clock Genes and The Silent Mating Type Information Regulation 2 Homolog 1 (Saccharomyces Cerevisiae) (Sirt1)mentioning

confidence: 99%

Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways

Maiese

2021

Biomolecules

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Neurodegenerative disorders affect fifteen percent of the world’s population and pose a significant financial burden to all nations. Cognitive impairment is the seventh leading cause of death throughout the globe. Given the enormous challenges to treat cognitive disorders, such as Alzheimer’s disease, and the inability to markedly limit disease progression, circadian clock gene pathways offer an exciting strategy to address cognitive loss. Alterations in circadian clock genes can result in age-related motor deficits, affect treatment regimens with neurodegenerative disorders, and lead to the onset and progression of dementia. Interestingly, circadian pathways hold an intricate relationship with autophagy, the mechanistic target of rapamycin (mTOR), the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), mammalian forkhead transcription factors (FoxOs), and the trophic factor erythropoietin. Autophagy induction is necessary to maintain circadian rhythm homeostasis and limit cortical neurodegenerative disease, but requires a fine balance in biological activity to foster proper circadian clock gene regulation that is intimately dependent upon mTOR, SIRT1, FoxOs, and growth factor expression. Circadian rhythm mechanisms offer innovative prospects for the development of new avenues to comprehend the underlying mechanisms of cognitive loss and forge ahead with new therapeutics for dementia that can offer effective clinical treatments.

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“…Phosphorylation or acetylation of FoxOs can change the binding of the C-terminal basic region to DNA to inhibit FoxO transcriptional activity [48,152,199,248]. FoxOs are intimately connected circadian rhythm since they are linked to SIRT1 [4,34,48,85,[248][249][250][251][252]. For example, insulin-phosphatidylinositol 3-kinase (PI3K) signaling that occurs in the liver is overseen by FoxO3 control of circadian rhythmicity through modulation of Clock.…”

Section: Mammalian Forkhead Transcription Factors (Foxos)mentioning

confidence: 99%

“…In regard to SIRT1, blockade of the activity of FoxOs by SIRT1 can promote cell survival [19,67,[249][250][251]. However, FoxOs can attach to the SIRT1 promoter region to further change forkhead transcription [181].…”

Section: Mammalian Forkhead Transcription Factors (Foxos)mentioning

confidence: 99%

Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm

Maiese

2021

Front Biosci (Landmark Ed)

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Introduction 3. Biological clocks and circadian rhythm pathways for dementia treatment 4. Circadian rhythm disruption and the wingless wnt pathway 5. The mechanistic target of rapamycin (mTOR) and autophagy 6. The silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) 7. Mammalian forkhead transcription factors (FoxOs) 8. Future perspectives 9. Author contributions 10. Ethics approval and consent to participate 11. Acknowledgment 12. Funding 13. Conflict of interest 14. References

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Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1

Abstract: AlFaris (2021) Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1,

Cited by 52 publications

References 51 publications

Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma

Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma

Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways

Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm

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