Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling

Alagal, Reham I.; AlFaris, Nora A.; Alshammari, Ghedeir M.; AlTamimi, Jozaa Z.; AlMousa, Lujain Abdulaziz; Yahya, Mohammed Abdo

doi:10.1016/j.jff.2021.104918

Cited by 8 publications

(10 citation statements)

References 51 publications

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“…The polyphenols in amaranth seed present high antioxidative activity and anti-inflammatory capacity as well as miscellaneous effects like anti-fibrotic, anti-bacterial, anti-hypertensive, anti-atherogenic and anti-proliferative effects [27]. Kaempferol, the major phenolic observed in our study, was reported to have a nephroprotective effect, preventing DOX-induced cardiac damage, hippocampal damage and neural and lung ischemia injury as well as an antioxidative effect [28,29]. Myricetin, the second-largest phenolic observed, possesses antimicrobial activity and has a positive effect on microbiota [30].…”

Section: Individual Phenolic Profilementioning

confidence: 55%

Amaranth Seed Polyphenol, Fatty Acid and Amino Acid Profile

Procopet

Oroian

2022

Applied Sciences

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In this paper, the extraction of polyphenols from amaranth seed using a Box–Benhken design using four factors—ultra-turrax speed, solid-to-liquid ratio (RSL), methanol concentration and extraction time—were studied. There were two responses studied for the model: total phenolic content (TPC) and total flavonoid content (TFC). The factors which influenced the most the extraction of the TPC and TFC were the RSL, methanol concentration and ultra-turrax speed. Twelve phenolic acids (rosmarinic acid, p-coumaric acid, chlorogenic acid, vanillic acid, caffeic acid, p-hydroxybenzoic acid, protocatechuic acid and gallic acid) and flavonoids (kaempferol, quercetin, luteolin and myricetin) were studied, and the most abundant one was kaempferol followed by myricetin. The amaranth seed is a valuable source of fatty acids, and 16.54% of the total fatty acids determined were saturated fatty acids, while 83.45% of the fatty acids were unsaturated ones. Amaranth seed is a valuable source of amino acids, with 9 essential amino acids being reported: histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine.

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Section: Individual Phenolic Profilementioning

confidence: 55%

Amaranth Seed Polyphenol, Fatty Acid and Amino Acid Profile

Procopet

Oroian

2022

Applied Sciences

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“…Doxorubicin, an anticancer agent, is widely used in the treatment of leukemia, breast cancer, and solid tumors [ 105 ]. Similar to other nephrotoxic drugs, there was an association between doxorubicin exposure and declining antioxidant parameters, such as glutathione peroxidase (GPx), SOD, and CAT, as well as SIRT1 activity [ 106 , 107 ]. Research showed that doxorubicin elevated thiobarbituric acid reactants (TBARS) and MDA, an indicator of oxidative damage [ 108 ].…”

Section: Kidney and Mitochondriamentioning

confidence: 99%

“…The formation of superoxide radical(s) by doxorubicin exposure led to apoptosis [ 111 , 112 ]. Further, doxorubicin-treated animals showed cell death and apoptosis characterized by upregulation of Bax, down-regulation of Bcl2, increased mitochondrial permeability, and activation of caspase-3 in kidneys [ 106 ].…”

Section: Kidney and Mitochondriamentioning

confidence: 99%

“…Furthermore, kaempferol inhibited the p38, ERK, and c-Jun N-terminal kinase (JNK) activation, while augmenting Coenzyme Q (CoQ) biosynthesis and content [ 97 ]. Treatment with kaempferol increased GSH and SOD2, while reducing TNF-α and IL-6 in the kidneys of doxorubicin-treated rats [ 106 ]. Moreover, treatment and pre-treatment with kaempferol in rats increased nuclear accumulation of Nrf2, which was necessary for mitochondrial biogenesis, in contrast to the cisplatin- and doxorubicin-treated animals [ 106 , 180 ].…”

Section: Antioxidants and Kidney Diseasesmentioning

confidence: 99%

“…Treatment with kaempferol increased GSH and SOD2, while reducing TNF-α and IL-6 in the kidneys of doxorubicin-treated rats [ 106 ]. Moreover, treatment and pre-treatment with kaempferol in rats increased nuclear accumulation of Nrf2, which was necessary for mitochondrial biogenesis, in contrast to the cisplatin- and doxorubicin-treated animals [ 106 , 180 ]. In addition, the protective effects of kaemepferol against streptozotocin-induced diabetic nephropathy could be attributed to its potent antioxidant effect, mediated by upregulation and activation of Nrf2 [ 188 ].…”

Section: Antioxidants and Kidney Diseasesmentioning

confidence: 99%

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The Effect of Polyphenols on Kidney Disease: Targeting Mitochondria

Ashkar

Bhullar

2022

Nutrients

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Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health. Through modulation of mitochondrial function, the kidneys are able to sustain or recover acute kidney injury (AKI), chronic kidney disease (CKD), nephrotoxicity, nephropathy, and ischemia perfusion. Therapeutic improvement in mitochondrial function in the kidneys is related to the regulation of adenosine triphosphate (ATP) production, free radicals scavenging, decline in apoptosis, and inflammation. Dietary antioxidants, notably polyphenols present in fruits, vegetables, and plants, have attracted attention as effective dietary and pharmacological interventions. Considerable evidence shows that polyphenols protect against mitochondrial damage in different experimental models of kidney disease. Mechanistically, polyphenols regulate the mitochondrial redox status, apoptosis, and multiple intercellular signaling pathways. Therefore, this review attempts to focus on the role of polyphenols in the prevention or treatment of kidney disease and explore the molecular mechanisms associated with their pharmacological activity.

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A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF‐κB inhibition and Nrf2 activation

et al. 2022

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Different toxins, including chemicals and natural, can be entered from various routes and influence human health. Herbal medicines and their active components can attenuate the toxicity of agents via multiple mechanisms. For example, kaempferol, as a flavonoid, can be found in fruits and vegetables, and has an essential role in improving disorders such as cardiovascular disorders, neurological diseases, cancer, pain, and inflammation situations. The beneficial effects of kaempferol may be related to the inhibition of oxidative stress, attenuation of inflammatory factors such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and nuclear factor ĸB (NF-ĸB) as well as the modulation of apoptosis and mitogen-activated protein kinase (MAPK) signaling pathways. This flavonoid boasts a wide spectrum of toxin targeting effects in tissue fibrosis, inflammation, and oxidative stress thus

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Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling

Cited by 8 publications

References 51 publications

Amaranth Seed Polyphenol, Fatty Acid and Amino Acid Profile

Amaranth Seed Polyphenol, Fatty Acid and Amino Acid Profile

The Effect of Polyphenols on Kidney Disease: Targeting Mitochondria

A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF‐κB inhibition and Nrf2 activation

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