KADAR TUMOR NECROSIS FACTOR-α PLASMA PADA BERBAGAI DERAJAT KEPARAHAN AKNE VULGARIS DI RSUD DR. SAIFUL ANWAR MALANG

Ekasari, Dhany Prafita; Sugiman, Tantari; Widiatmoko, Arif

doi:10.21776/ub.majalahkesehatan.005.02.3

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Research on serum IL-12 levels in patients with AV found that IL-12 levels in AV patients were significantly higher than in the control group. 33 Based on the results of the study, it was found that IL-12 levels in the AV patient group were higher than the control group. IL-12 levels in severe AV patients were higher than IL-12 levels in moderate AV patients.…”

Section: Resultsmentioning

confidence: 93%

The Difference in Interleukin-12 (IL-12) on Degrees of Acne Vulgaris Severity

Sibero¹,

Darwin²,

Wirasati³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Introduction: Acne vulgaris (AV) is a common disorder of pilosebaceous seen mainly in adolescents. Most cases of AV present with a pleomorphic lesion array, consisting of blackheads, papules, pustules, and nodules of varying severity. Acne is one of the three most common skin disease, especially in adolescents and young adults, with an estimated prevalence of 85% (aged 12-25 years). Acne vulgaris (AV) is still a health problem in the world and Indonesia. The causes of AV are multifactorial and can lead to various complications. Aim: This study looked for the difference in interleukin-12 (IL-12) on degrees of AV severity. Materials and Method: This study was an observational analytic study with a cross-sectional approach. The research was conducted at the Diniyah Putri Islamic Boarding School, Lampung Province, Indonesia, in August 2020. The independent variable in this study was the AV degree, while the dependent variable was the IL-8 level. The sampling method in this study was consecutive sampling, as many as 63 AV patients. The research material is serum from venous blood. Examination of interleukin-8 levels using the ELISA method. Data analysis was univariate to find the mean and standard deviation of IL-8 levels, as well as the frequency distribution to determine the degree of AV. While the bivariate analysis was to determine the difference in the mean of IL-8 levels in AV patients. Results: The mean age of the respondents was 15.49 ± 1.07 years, the mean IL-12 level was 48.22 ± 15.62 and most of the AV degrees were in a severe category as much as 61.9%. Conclusion: Statistically there is no difference in the mean IL-12 levels in moderate and severe AV patients, but IL-12 levels are higher at severe AV degrees than moderate AV degrees.

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Section: Resultsmentioning

confidence: 93%

The Difference in Interleukin-12 (IL-12) on Degrees of Acne Vulgaris Severity

Sibero¹,

Darwin²,

Wirasati³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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“…Adolescents tend to have a higher risk of developing AV to a more severe degree than adults. 22 A similar study on college students found that most respondents had mild AV severity (93%) and moderate AV severity (7%). Most of the degree of AV severity is mild, possibly due to facial care factors that have been done by female students.…”

Section: Methodsmentioning

confidence: 87%

The Difference in Interleukin-8 (IL-8) on Degrees of Acne Vulgaris Severity

2021

IJFMT

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Background: Acne vulgaris (AV) is a follicular disease that occurs most often and affects the area containing sebaceous gland follicles, including the face, back, and body. This is a multifactorial condition. The prevalence of acne vulgaris (AV) is still high both in the world and in Indonesia. As many as 80% of AV is found at the age of 11-30 years and almost 100% in adolescents. Various factors can trigger the onset of AV which can lead to severe complications. Aim: This study looked for the difference in interleukin-8 (IL-8) on degrees of AV severity. Materials and method: This study was an observational analytic study with a crosssectional approach. The research was conducted at the Diniyah Putri Islamic Boarding School, Lampung Province, Indonesia, in August 2020. The independent variable in this study was the AV degree, while the dependent variable was the IL-8 level. The sampling method in this study was consecutive sampling, as many as 63 AV patients. The research material is serum from venous blood. Examination of interleukin-8 levels using the ELISA method. Data analysis was univariate to find the mean and standard deviation of IL-8 levels, as well as the frequency distribution to determine the degree of AV. While the bivariate analysis was to determine the difference in the mean of IL-8 levels in AV patients. Results: The mean of IL-8 levels in AV patients was 38.53. Most of the AV patients are in a severe category. Further analysis found no difference in the mean of IL-8 levels between moderate and severe AV degrees. Conclusion: There was no difference in the mean of IL-8 levels in moderate and severe AV patients, but the IL-8 levels at severe AV degrees were higher than moderate AV degrees.

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“…33 ISSUE 3 medicinus 28 kemudian berkembang menjadi lesi inflamasi sebagai akibat dari aktivasi dan migrasi sel T CD4 + , produksi sitokin oleh keratinosit, 19,20 Pada lesi inflamasi AV, keberadaan P. acnes memberikan kontribusi terhadap inisiasi dan pemeliharaan proses inflamasi dengan menginduksi sitokin proinflamasi dan enzim yang merusak jaringan seperti protein dan hialuronidase. 21,22 Populasi P. acnes yang berlebih akan mengaktivasi respons imun tubuh, salah satunya dengan menstimulasi keratinosit untuk menghasilkan sitokin proinflamasi seperti TNF-α. 23 Pada patogenesis AV, TNF-α terutama berperan pada pembentukan lesi inflamasi AV.…”

Section: Pembahasanunclassified

Pengaruh <i>Astaxantine</i> Oral terhadap Kadar Serum <i>Tumor Necrosis Factor Alpha</i> pada Pasien Akne Vulgaris-lores

et al. 2020

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Latar belakang: Acne vulgaris (AV) merupakan penyakit inflamasi kronis pada unit pilosebasea dengan manifestasi klinis berupa komedo terbuka dan tertutup, papul, pustul dan nodul. Terapi AV umumnya melibatkan lebih dari satu obat dikarenakan patogenesis AV yang multifaktorial. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian astaxanthin oral 4 mg sebagai terapi adjuvan AV terhadap penurunan kadar serum tumor necrosis factor alpha (TNF-α) yang merupakan salah satu penanda inflamasi. Metode: Penelitian ini merupakan penelitian double-blind randomized controlled trial. Sampel berjumlah 34 pasien AV derajat ringan dan sedang (skor Global Acne Grading System/GAGS 1-30) yang diobati dengan kombinasi tretinoin 0,025% dan clindamycin phosphate 1,2%. Pada kelompok perlakuan ditambahkan terapi dengan astaxanthin sementara pada kelompok kontrol diberikan plasebo berisi laktulosa selama 4 minggu. Hasil pretest dan posttest pada kedua kelompok dianalisis secara statistik menggunakan uji nonparametrik. Hasil: Penurunan kadar serum TNF-α terjadi pada kedua kelompok, namun perbedaan yang bermakna dengan baseline hanya dijumpai pada kelompok pelakuan (p=0,015). Tidak terdapat perbedaan bermakna pada perbandingan penurunan kadar serum TNF-α pada kelompok perlakuan dan kontrol (p=0,459). Kesimpulan: Meskipun secara keseluruhan tidak menunjukkan perbedaan yang bermakna, namun pemberian astaxanthin dapat menurunkan kadar serum TNF-α secara bermakna terhadap baseline pada pasien acne vulgaris.

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KADAR TUMOR NECROSIS FACTOR-α PLASMA PADA BERBAGAI DERAJAT KEPARAHAN AKNE VULGARIS DI RSUD DR. SAIFUL ANWAR MALANG

Cited by 3 publications

References 26 publications

The Difference in Interleukin-12 (IL-12) on Degrees of Acne Vulgaris Severity

The Difference in Interleukin-12 (IL-12) on Degrees of Acne Vulgaris Severity

The Difference in Interleukin-8 (IL-8) on Degrees of Acne Vulgaris Severity

Pengaruh <i>Astaxantine</i> Oral terhadap Kadar Serum <i>Tumor Necrosis Factor Alpha</i> pada Pasien Akne Vulgaris-lores

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