K021 Left ventricular mass and circulating growth factors in essential hypertension

Cottone, S.; Nardi, Emilio; Vadalà, Anna; Riccobene, Raffaella; Vella, M.C.; Neri, Anna Lisa; Mulè, Giuseppe; Piazza, G.; Zagarrigo, Carmela; Cerasola, Giovanni

doi:10.1016/s0895-7061(97)91402-3

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“…ET-1 plasma levels, however, have been found to be either normal or elevated in human arterial hypertension [14][15][16][17], probably because circulating levels of ET-1 do not closely correspond to the concentration of the peptide within the vessel wall.…”

Section: Discussionmentioning

confidence: 97%

“…Further, results concerning circulating ET-1 levels in essential hypertensives appear to be quite discripant [ [14][15][16][17], while in vitro and in vivo studies [11,12,17] have demonstrated the existence of a relationship between ET-1 and bFGF and of bFGF with PDGF. Considering this evidence and the demonstration of an involvement of both bFGF and ET-1 in vascular changes we carried out the present study, aimed at investigating the behaviour of circulating ET-1, bFGF and PDGF in healthy normotensive and essential hypertensive subjects after vascular load induced by isometric physical exercise.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Vascular Load on Plasma Endothelin-1, Cytokines and Catecholamine Levels in Essential Hypertensives

COTTONE

1998

Blood Pressure

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In vitro studies demonstrated a relationship between ET-1 and basic Fibroblast Growth Factor (bFGF), and of bFGF with Platelet Derived Growth Factor (PDGF). The present study was carried out to investigate in vivo the behaviour after vascular stress of circulating ET-1, bFGF and PDGF, and catecholamines, and their relationship. In 12 healthy normotensives (NTs) and 15 essential hypertensives (Ehs) venous blood samples to determine circulating ET-1, bFGF and PDGF, and catecholamine (EPI and NE) levels were drawn before and at the third minute of a handgrip test. Blood pressures (BP) and heart rate were automatically recorded before starting, and at 1, 2, and 3 minutes during the test. The NTs showed, in basal condition, lower values than the EHs of all the examined parameters; later, the handgrip test induced significant increases in circulating levels of ET-1, bFGF and catecholamine. In the EHs at the third minute of the exercise significant increases in plasma ET-1 (p < 0.002), bFGF (p < 0.006), and EPI and NE (p < 0.0005) levels were observed. Systolic and diastolic BP significantly increased after handgrip test in NTs and EHs. Plasma ET-1 correlated with bFGF both before (p < 0.01) and at the acme (p < 0.05) of the isometric exercise. Our results show that in EHs plasma ET-1 and bFGF correlate each other, indicating that in human hypertension a linkage between ET-1 and bFGF exists.

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Section: Discussionmentioning

confidence: 97%