Influence of Vascular Load on Plasma Endothelin-1, Cytokines and Catecholamine Levels in Essential Hypertensives

COTTONE, MARIA C. VELLA SANTINA

doi:10.1080/080370598437349

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…There are few data showing increases in circulating vasoconstrictor hormones during static exercise, but they have been obtained in subjects varying in age and health status. It was demonstrated, therefore, that static handgrip caused an increase in plasma vasopressin in healthy young men (Nazar et al 1989), and endothelin-1 in hypertensive patients (Cottone et al 1998), young normotensive offspring of hypertensive parents (Mangieri et al 1998) and patients with congestive heart failure (Mangieri et al 1997). On the other hand, we have recently demonstrated that static handgrip caused also an increase in the plasma adrenomedullin (ADM), which is a potent vasorelaxant probably involved in the fine blood pressure control counteracting the effect of vasoconstrictors.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

et al. 2011

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The purpose of this study was to investigate the effect of age on cardiovascular changes and plasma concentrations of adrenomedullin (ADM), catecholamines, endothelin-1 (ET-1) and plasma renin activity (PRA) in healthy men. A total of 15 young (21 ± 0.3 years) and 15 older (64 ± 0.7 years) healthy men performed two 3-min bouts of static handgrip at 30% of maximal voluntary contraction, alternately with each hand without any break between the bouts. During exercise heart rate (HR), blood pressure (BP), stroke volume (SV) and pre-ejection period (PEP) and left ventricle ejection time (LVET) were measured. Blood samples were taken before exercise, at the end of both exercise bouts and in the fifth minute of the recovery period. The handgrip-induced increases in HR and cardiac output were significantly smaller in older than in young men (p < 0.01). SV decreased only in older men (p < 0.001). There were no differences between groups in BP increases. The baseline plasma ADM and catecholamines were higher in older man compared to young subjects. Handgrip caused increases in plasma ADM, ET-1 and PRA only in older men (p < 0.05). The increases in plasma ADM correlated positively with those of noradrenaline (NA), PRA, ET-1 and LVET and negatively with changes in total peripheral resistance (TPR), SV, PEP and PEP/LVET ratio. The increases in plasma ET-1 correlated positively with those of NA, PRA, TPR, mean BP and SV. These results revealed that ADM, ET-1 and angiotensin II can contribute to maintain vascular tone during static exercise in older but not in younger men.

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Section: Introductionmentioning

confidence: 99%

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

et al. 2011

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“…Among these studies, the vast majority (76.5%) performed the handgrip, followed by knee extension (13.7%) (Table 1 , Ref. [ 8 , 13 , 18 , 19 , 20 , 22 , 23 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ...…”

Section: Resultsmentioning

confidence: 99%

Acute Blood Pressure Response to Different Types of Isometric Exercise: A Systematic Review with Meta-Analysis

CONEGLIAN¹,

BARCELOS²,

BANDEIRA³

et al. 2023

Rev. Cardiovasc. Med.

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Background: This study aimed to identify the blood pressure (BP) responses during different types of isometric exercises (IE) in adults and to evaluate whether BP responses according to IE is influenced by the characteristics of participants and exercise protocols. Methods:The search was conducted in PubMed, Cochrane Central, SPORTDiscus, and LILACS databases in June 2020. Random effects models with a 95% confidence interval and p < 0.05 were used in the analyses. Results: Initially, 3201 articles were found and, finally, 102 studies were included in this systematic review, seven of which were included in the meta-analysis comparing handgrip to other IE. Twoknee extension and deadlift promoted greater increases in systolic (+9.8 mmHg; p = 0.017; I 2 = 74.5% and +26.8 mmHg; p ≤ 0.001; I 2 = 0%, respectively) and diastolic (+7.9 mmHg; p = 0.022; I 2 = 68.6% and +12.4 mmHg; p ≤ 0.001; I 2 = 36.3%, respectively) BP compared to handgrip. Men, middle-aged/elderly adults, hypertensive individuals, and protocols with higher intensities potentiate the BP responses to handgrip exercise (p ≤ 0.001). Conclusions: IE involving larger muscle groups elicit greater BP responses than those involving smaller muscle masses, especially in men, middle-aged/elderly adults and hypertensive individuals. Future studies should directly compare BP responses during various types of IE in different populations.

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Endothelium-derived factors in microalbuminuric and nonmicroalbuminuric essential hypertensives

Cottone¹,

Vadalà²,

Mangano³

et al. 2000

American Journal of Hypertension

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Previous evidence has demonstrated a relationship between growth factors and cardiovascular diseases. This study was aimed at evaluating levels of some endothelium-derived growth factors, and their relationship with microalbuminuria (MAU), in essential hypertension. Ninety-nine mild-moderate essential hypertensives (EH) and 25 healthy controls were studied. All patients underwent 24-h blood pressure monitoring, serum endothelin-1 (ET-1), basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF), and 24-h MAU assays. Later, EH were divided into two subsets consisting of microalbuminurics (MAU >11 microg/min) and nonmicroalbuminurics (MAU <11 microg/min). In microalbuminuric EH, circulating ET-1, bFGF, and PDGF were significantly higher than in nonmicroalbuminurics (P < .0001, P < .0001, P < .005, respectively) or in controls. In the group of 99 EH, significant positive correlations of MAU with both ET-1 and bFGF (r = 0.35, P < .001, and r = 0.34, P < .001, respectively) were found. ET-1 and bFGF correlated significantly (r = 0.31, P < .002). Circulating bFGF also correlated significantly with MAU in the microalbuminuric EH subset (r = 0.49, P < .01). Our results show that in microalbuminuric EH circulating levels of certain growth factors are increased. In human essential hypertension these factors are linked with MAU, an early cardiovascular and renal damage marker.

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Influence of Vascular Load on Plasma Endothelin-1, Cytokines and Catecholamine Levels in Essential Hypertensives

Cited by 8 publications

References 19 publications

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

Acute Blood Pressure Response to Different Types of Isometric Exercise: A Systematic Review with Meta-Analysis

Endothelium-derived factors in microalbuminuric and nonmicroalbuminuric essential hypertensives

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