Endothelium-derived factors in microalbuminuric and nonmicroalbuminuric essential hypertensives

Cottone, Santina; Vadalà, Anna; Mangano, M T; Riccobene, Raffaella; Vella, M.C.; Neri, Anna Lisa; Mulè, Giuseppe; Piazza, G.; Amato, F.; Zagarrigo, Carmela; Cerasola, Giovanni

doi:10.1016/s0895-7061(99)00169-7

Cited by 20 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…VEGF may induce microalbuminuria by afferent glomerular arteriolar vasodilation and enhanced EC permeability. ET-1, FGF-2 and PDGF-AB levels are elevated in hypertensive patients with microalbuminuria compared to hypertensive patients without microalbuminuria and to normotensive controls [93]. Early clinical trials with FGF-2 have also reported proteinuria as a significant side effect [21,94].…”

Section: Potential Clinical Significance Of Elevated Vegf Levels In Hmentioning

confidence: 99%

“…Levels of insulin growth factor binding protein-1 (IGBP-1) are elevated in hypertension [51]. FGF-2 levels are elevated in mild-moderate hypertension compared with normotensive controls [52]. PDGF-AB levels are not elevated in hypertensive patients compared to controls, except in the subset of hypertensive patients with microalbuminuria [52].…”

Section: Angiogenic Growth Factor Levels In Hypertensionmentioning

confidence: 99%

“…FGF-2 levels are elevated in mild-moderate hypertension compared with normotensive controls [52]. PDGF-AB levels are not elevated in hypertensive patients compared to controls, except in the subset of hypertensive patients with microalbuminuria [52]. Endothelin-1 (ET-1), which stimulates angiogenesis directly, as well as indirectly by inducing VEGF [53] is elevated in hypertensive patients [52].…”

Section: Angiogenic Growth Factor Levels In Hypertensionmentioning

confidence: 99%

“…PDGF-AB levels are not elevated in hypertensive patients compared to controls, except in the subset of hypertensive patients with microalbuminuria [52]. Endothelin-1 (ET-1), which stimulates angiogenesis directly, as well as indirectly by inducing VEGF [53] is elevated in hypertensive patients [52]. Transforming growth factor-b 1 has a complex role in angiogenesis with deficits in its signaling pathway causing impairments of vascular development and physiology [54].…”

Section: Angiogenic Growth Factor Levels In Hypertensionmentioning

confidence: 99%

See 3 more Smart Citations

Angiogenic growth factors and hypertension

2004

View full text Add to dashboard Cite

Emerging evidence supports a novel view of hypertension as a disease of inadequate or aberrant responses to angiogenic growth factors (AGF). Patients with hypertension have reduced microvascular density, with some evidence supporting a primary role for rarefaction in causing hypertension. Two clinical models have demonstrated a link between inhibition of AGF activity and hypertension. A major side effect of bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), is hypertension. Pre-eclampsia is accompanied by high circulating levels of soluble VEGF receptor-1, which forms inactive complexes with VEGF and placental growth factor (PlGF). Paradoxically, early studies have demonstrated high circulating levels of AGF in hypertension. Several mechanisms may account for this finding including increased vascular stretch, tissue ischemia, compensatory responses, decreased clearance or a combination of these mechanisms. High AGF in hypertension could contribute to clinical sequelae such as peripheral and pulmonary edema, microalbuminuria, and progression of atherosclerosis. However, a role for altered angiogenesis in the pathogenesis of hypertension or its sequelae has not been established. Novel studies to understand the roles of AGF in hypertensive patients are warranted.

show abstract

Section: Potential Clinical Significance Of Elevated Vegf Levels In Hmentioning

confidence: 99%

Section: Angiogenic Growth Factor Levels In Hypertensionmentioning

confidence: 99%

Section: Angiogenic Growth Factor Levels In Hypertensionmentioning

confidence: 99%

Section: Angiogenic Growth Factor Levels In Hypertensionmentioning

confidence: 99%

See 2 more Smart Citations

Angiogenic growth factors and hypertension

2004

View full text Add to dashboard Cite

show abstract

“…30 It is also important to discuss in this same context the relationship of microalbuminuria and endothelial function, a parameter frequently abnormal in essential hypertension, that may precede and accelerate atherosclerotic progression. 31 On one hand, consistent evidence does suggest that hypertensive microalbuminuria is associated with circulating markers of endothelial dysfunction, [32][33][34][35] including von Willebrand Factor, an endothelial haemostatic factor and a predictor of cardiovascular death. 36 On the other hand, however, urine albumin was dissociated from both the transcapillary 125 I-albumin escape rate, a measure of systemic capillary permeability, 28,37 and forearm vasodilatation to acetylcholine, 38 a compound that releases nitric-oxide from endothelial cells.…”

Section: Journal Of Human Hypertensionmentioning

confidence: 99%

Dissociation between microalbuminuria and common carotid thickness in essential hypertensive men

et al. 2000

View full text Add to dashboard Cite

Background: The reasons why microalbuminuria (albuminuria у15 g/min), an expression of a renal microcirculatory abnormality, predicts cardiovascular disease in essential hypertension are unsettled. To test the hypothesis that microalbuminuria represents a marker of subclinical atherosclerosis, we evaluated its association with common carotid artery (CCA) intima media thickness (IMT), a measure of preclinical atherosclerosis and an independent predictor of cardiac and cerebrovascular events, in uncomplicated essential hypertensive individuals. Materials and methods: Albuminuria, ultrasonographic CCA IMT (the mean of six bilateral far wall measurements within 1.5 cm proximally to the flow divider), brachial blood pressure (BP), smoking habits and lipids were evaluated in 136 stage 1-3 untreated essential hypertensive men free of cardiovascular disease. Results: CCA IMT did not differ between normo-(n ‫؍‬ 99) and microalbuminuric (n ‫؍‬ 37) patients. The correlation

show abstract

Subclinical Kidney Damage in Hypertensive Patients: A Renal Window Opened on the Cardiovascular System. Focus on Microalbuminuria

Mulè

Castiglia

Cusumano

et al. 2016

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

The kidney is one of the major target organs of hypertension.Kidney damage represents a frequent event in the course of hypertension and arterial hypertension is one of the leading causes of end-stage renal disease (ESRD).ESRD has long been recognized as a strong predictor of cardiovascular (CV) morbidity and mortality. However, over the past 20 years a large and consistent body of evidence has been produced suggesting that CV risk progressively increases as the estimated glomerular filtration rate (eGFR) declines and is already significantly elevated even in the earliest stages of renal damage. Data was supported by the very large collaborative meta-analysis of the Chronic Kidney Disease Prognosis Consortium, which provided undisputable evidence that there is an inverse association between eGFR and CV risk. It is important to remember that in evaluating CV disease using renal parameters, GFR should be assessed simultaneously with albuminuria.Indeed, data from the same meta-analysis indicate that also increased urinary albumin levels or proteinuria carry an increased risk of all-cause and CV mortality. Thus, lower eGFR and higher urinary albumin values are not only predictors of progressive kidney failure, but also of all-cause and CV mortality, independent of each other and of traditional CV risk factors.Although subjects with ESRD are at the highest risk of CV diseases, there will likely be more events in subjects with mil-to-moderate renal dysfunction, because of its much higher prevalence.These findings are even more noteworthy when one considers that a mild reduction in renal function is very common in hypertensive patients.The current European Society of Hypertension (ESH)/European Society of Cardiology (ESC) guidelines for the management of arterial hypertension recommend to sought in every patient signs of subclinical (or asymptomatic) renal damage. This was defined by the detection of eGFR between 30 mL/min/1.73 m and 60 mL/min/1.73 m or the presence of microalbuminuria (MAU), that is an amount of albumin in the urine of 30-300 mg/day or an albumin/creatinine ratio, preferentially on morning spot urine, of 30-300 mg/g.There is clear evidence that urinary albumin excretion levels, even below the cut-off values used to define MAU, are associated with an increased risk of CV events. The relationships of MAU with a variety of risk factors, such as blood pressure, diabetes and metabolic syndrome and with several indices of subclinical organ damage, may contribute, at least in part, to explain the enhanced CV risk conferred by MAU. Nonetheless, several studies showed that the association between MAU and CV disease remains when all these risk factors are taken into account in multivariate analyses. Therefore, the exact pathophysiological mechanisms explaining the association between MAU and CV risk remain to be elucidated. The simple search for MAU and in general of subclinical renal involvement in hypertensive patients may enable the clinician to better assess absolute CV risk, and its identification may induc...

show abstract

Endothelium-derived factors in microalbuminuric and nonmicroalbuminuric essential hypertensives

Cited by 20 publications

References 19 publications

Angiogenic growth factors and hypertension

Angiogenic growth factors and hypertension

Dissociation between microalbuminuria and common carotid thickness in essential hypertensive men

Subclinical Kidney Damage in Hypertensive Patients: A Renal Window Opened on the Cardiovascular System. Focus on Microalbuminuria

Contact Info

Product

Resources

About