JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2

Zhao, Xue; Wang, Rihua; Xiong, Jianping; Yan, Donglin; Li, Aiping; Wang, Shouyu; Xu, Jin; Zhou, Jianwei

doi:10.1016/j.toxlet.2017.04.011

Cited by 29 publications

(16 citation statements)

References 31 publications

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“…1B). The concentration-response (decreased viability) relationship observed in this study was matched well to previous studies (Yang et al, 2009;Zhao et al, 2017). Since the treatment with 600 μM of PQ significantly decreased cell viabilities within 24 hr (Fig.…”

Section: Pq Decreases the Viability Of Sh-sy5y Cells In Time-and Dosesupporting

confidence: 91%

“…Primers used in this study. SH-SY5Y cells are more sensitive to PQ than other cells (Zhao et al, 2017). We also examined effects of these inhibitors on SH-SY5Y cell death by chelerythrine, which is also a mitochondrial toxin and induces rapid apoptotic cell death (Kaminskyy et al, 2008;Funakoshi et al, 2011).…”

Section: Effects Of Inhibitors Of Apoptosis Necroptosis and Ferroptmentioning

confidence: 99%

“…The aim of this study is to obtain in-depth understanding of neurotoxicity of PQ by use of in vitro system. For this purpose, SH-SY5Y human neuroblastoma was selected because the cell is an established model to examine neurotoxicity of chemicals as well as stresses (Cheung et al, 2009;Xicoy et al, 2017) and is shown more sensitive to PQ toxicity than other cells (Zhao et al, 2017). We examined the possible involvement of recently discovered forms of cell death in SH-SY5Y human neuroblastoma cells during PQ exposure, as well as the involvement of other cell deathregulating mechanisms such as the mitochondrial damage response and autophagy.…”

Section: Introductionmentioning

confidence: 99%

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Necrosis in human neuronal cells exposed to paraquat

Hirayama¹,

Aki²,

Funakoshi³

et al. 2018

J. Toxicol. Sci.

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-Paraquat (PQ) is an herbicide that was once used worldwide, but is now prohibited in many nations due to its high toxicity to humans. However, there are still rare cases of the fetal intoxication of PQ, which was purchased prior to the prohibition in Japan. In this study, several cell death pathways, the mitochondrial stress response, and autophagy were examined in SH-SY5Y cells exposed to PQ. The results reveal the decrease of a mitochondrial stress sensitive-BNIP3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) protein, the suppression of autophagic flux, and the lack of apoptosis as well as other regulated forms of necrosis, such as necroptosis and ferroptosis. Taken together, our preliminary survey of cellular responses against PQ shows that, although responses of mitochondria and autophagy are observed, subsequent cell death is necrosis. Mechanism of PQ-induced SH-SY5Y cell death should be complicated and cannot be explained thoroughly by already-known mechanisms.

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Section: Pq Decreases the Viability Of Sh-sy5y Cells In Time-and Dosesupporting

confidence: 91%

Section: Effects Of Inhibitors Of Apoptosis Necroptosis and Ferroptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Necrosis in human neuronal cells exposed to paraquat

Hirayama¹,

Aki²,

Funakoshi³

et al. 2018

J. Toxicol. Sci.

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“…Keap1/Nrf2/ARE pathway An efficient repressor system to keep homeostasis (124) is the Keap1-Nrf2 pathway, which triggers the Antioxidant Response Element (ARE), which, in turn, is involved in the expression of antioxidant enzyme genes (124)(125)(126). Under oxidative stress, multiple cysteines on Keap1 react with reactive oxygen species (ROS) and lead to a conformational change that releases Nrf2 (127).…”

Section: Neuroprotective Mechanisms and Pyrethroid Toxicitymentioning

confidence: 99%

Pyrethroid exposure and neurotoxicity: a mechanistic approach

Mohammadi

Ghassemi-Barghi

Malakshah

et al. 2019

Archives of Industrial Hygiene and Toxicology

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Pyrethroids are a class of synthetic insecticides that are used widely in and around households to control the pest. Concerns about exposure to this group of pesticides are now mainly related to their neurotoxicity and nigrostriatal dopaminergic neurodegeneration seen in Parkinson’s disease. The main neurotoxic mechanisms include oxidative stress, inflammation, neuronal cell loss, and mitochondrial dysfunction. The main neurodegeneration targets are ion channels. However, other receptors, enzymes, and several signalling pathways can also participate in disorders induced by pyrethroids. The aim of this review is to elucidate the main mechanisms involved in neurotoxicity caused by pyrethroids deltamethrin, permethrin, and cypermethrin. We also review common targets and pathways of Parkinson’s disease therapy, including Nrf2, Nurr1, and PPARγ, and how they are affected by exposure to pyrethroids. We conclude with possibilities to be addressed by future research of novel methods of protection against neurological disorders caused by pesticides that may also find their use in the management/treatment of Parkinson’s disease.

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“…Por otra parte, la neurotoxicidad surge del desequilibrio del estado redox de las células nerviosas. La alta exposición de los pulmones y de los riñones al gasto cardiaco hace que estos órganos entren en contacto con mayores cantidades del herbicida y de mediadores inflamatorios 1,13,[15][16][17] .…”

Section: Discussionunclassified

Intoxicación por paraquat y convulsiones: a propósito de un caso en una institución de salud de Pasto, Nariño

Ordóñez

Zarama

2020

MedUPB

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Caso clínico de un hombre de 20 años, procedente de área rural de un municipio de Nariño, que consulta a un centro de salud después de 36 horas de haber ingerido de modo no intencional 20-30 mL de gramoxone (dicloruro de paraquat) mientras estaba en estado de embriaguez, con síntomas digestivos, hiperbilirrubinemia, elevación de azoados, leucocitosis y neutrofilia, por lo que es referido a un hospital de alta complejidad en la ciudad de Pasto. Durante su hospitalización, presenta epistaxis, falla renal con requerimiento de hemodiálisis, quemaduras orales, hipertermia y dos episodios de crisis convulsivas tónico-clónico generalizadas. Se toman paraclínicos: azoados, gases arteriales, electrolitos, glicemia, entre otros, cuyos resultados se enmarcan dentro de la normalidad durante los episodios convulsivos. Es relevante proporcionar elementos para construir un criterio clínico que explique el compromiso neurológico, ya que, es raro y complejo en intoxicaciones por herbicidas como el paraquat.

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JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2

Cited by 29 publications

References 31 publications

Necrosis in human neuronal cells exposed to paraquat

Necrosis in human neuronal cells exposed to paraquat

Pyrethroid exposure and neurotoxicity: a mechanistic approach

Intoxicación por paraquat y convulsiones: a propósito de un caso en una institución de salud de Pasto, Nariño

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