Juxtaglomerular Cell Tumor without Hypertension

Hayami, Shinsuke; Sasagawa, Isoji; Suzuki, Hitoshi; Kubota, Yōko; Nakada, Teruhiro; Endo, Yasushi

doi:10.1080/003655998750015656

Cited by 24 publications

(3 citation statements)

References 4 publications

(5 reference statements)

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“…This may be related to the JCT originating from the modified smooth muscle cells that comprises the vascular component of the juxtaglomerular apparatus. [ 20 21 ] Juxtaglomerular cells are near the pelvis parenchyma.…”

Section: Discussionmentioning

confidence: 99%

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Magnetic Resonance Imaging Features of a Juxtaglomerular Cell Tumor

Kang

Guo

Wang

et al. 2015

Journal of Clinical Imaging Science

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Objective:To retrospectively determine whether magnetic resonance imaging (MRI) findings can help differentiate a juxtaglomerular cell tumor (JCT) from clear cell renal cell carcinoma (ccRCC).Materials and Methods:Eight patients with JCTs and 24 patients with pathologically proven ccRCC were included for image analysis. All patients underwent unenhanced MRI and dynamic contrast-enhanced MRI. Fat-suppressed T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), in- and opposed-phase imaging, and fat-suppressed preliver acquisitions with volume acceleration sequences were performed before enhancement. After the administration of contrast, dynamic imaging was performed in the corticomedullary, nephrographic, and excretory phases. Student's t-test, t′-test, Chi-square test, and nonparametric Kruskal–Wallis H-test were used to determine the significance of the difference between the two groups. The sensitivity and specificity of the MRI findings were calculated.Results:In patients with a JCT, a cystic part of the lesion of <10%, isointensity or mild hyperintensity on T2WI, heterogeneous hyperintensity on DWI, less signal drop (<10%) in in- and opposed-phase imaging, and a degree of enhancement <200% in the corticomedullary phase showed statistically significant differences compared with those of ccRCC (P < 0.05). After combining a lower apparent diffusion coefficient (ADC) value (heterogeneous hyperintensity) on DWI and a degree of enhancement <200% in the corticomedullary phase using a parallel test, the sensitivity and specificity were 90.9% and 91.7%, respectively.Conclusions:Isointensity or mild hyperintensity on T2WI, a lower ADC value (heterogeneous hyperintensity) on DWI, and a degree of enhancement <200% in the corticomedullary phase are the major MRI findings for JCTs, combined with relative clinical manifestations and excluding other renal masses. A main solid tumor, less signal drop (<10%) in in- and opposed-phase imaging, and a less-washout pattern of <10% in the delayed phase are secondary MRI findings for JCTs.

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Section: Discussionmentioning

confidence: 99%

“…The renal angiographic findings also showed a hypovascular area or no abnormal vascularities. [ 3 21 25 ] The pathology of the JCTs, however, contained a prominent vasculature. [ 20 ] Our study and another report[ 2 ] showed a mild enhancement in most cases of JCT.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Features of a Juxtaglomerular Cell Tumor

Kang

Guo

Wang

et al. 2015

Journal of Clinical Imaging Science

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“…Second most common presentation is the atypical variant showing hypertension with normal potassium level [8]. The third, non-functioning variant is very rare and is characterized by a normal blood pressure and normal potassium level [14-16]. Clinicians should strongly suspect JGCT if they encounter adolescent or young adult patients with severe or even moderate hypertension associated with an unexplained secondary hyperaldosteronism [6].…”

Section: Introductionmentioning

confidence: 99%

Review of juxtaglomerular cell tumor with focus on pathobiological aspect

et al. 2011

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Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.

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Tumours of vessel wall components and vascular related structures

Vuong

Berry

2002

The Pathology of Vessels

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Juxtaglomerular Cell Tumor without Hypertension

Cited by 24 publications

References 4 publications

Magnetic Resonance Imaging Features of a Juxtaglomerular Cell Tumor

Magnetic Resonance Imaging Features of a Juxtaglomerular Cell Tumor

Review of juxtaglomerular cell tumor with focus on pathobiological aspect

Tumours of vessel wall components and vascular related structures

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