Juvenile Xanthogranuloma With Inconspicuous Foam Cells and Giant Cells

Mononuclear variant of juvenile xanthogranuloma in the oral cavity of an adult patient

“…In conclusion, a mononuclear form of JXG seems the only reasonable diagnosis of this very peculiar case which histologically is identical to previously published cases 4–8 …”

“…A subtype of JXG was recently described in which giant plurinucleated Touton cells are distinctively absent or very scant 4–8 . These cases are probably nothing more than an evolving stage or a late form of JXG in which Touton cells are not yet formed or have regressed.…”

Nonlipidized juvenile xanthogranuloma: An unusual variant with a potential diagnostic pitfall

“…Amongst these variants nonlipidized, intramuscular and subcutaneous JXG present rare or no Touton giant cells, difficulting the diagnosis [2]. NJXG is a welldocumented histological subtype, with over 28 published cases in the English-language literature, most affecting the skin [2,[4][5][6][7][8][9][10][11][12]. Clinically, NJXG predominantly occurs in infants 6 months of age or younger.…”

“…Histologically, nonlipidized JXG (NJXG) consists of a diffuse, monomorphic, histiocytic infiltrate with a relative absence or lack of inflammatory cells, foamy histiocytes, foreign body and Touton giant cells, usually showing a high mitotic index. To date, about 28 NJXG cases affecting extra-oral sites have been described in the literature [2,[4][5][6][7][8][9][10][11][12]. Only 4 cases of non-classic JXG involving the mouth, described as ''early JXG'' or ''mononuclear variant of JXG'', have been reported [13,14] and none of them showed mitotic activity nor it was considered the possibility of malignancy.…”

Juvenile xanthogranuloma: Case report with immunohistochemical identification of early and late cytomegalovirus antigens.

“…Juvenile xanthogranuloma (JXG) is a benign fibrohistiocytic tumor occurring most commonly during infancy and presenting as multiple or solitary slightly elevated, yellow-brown papules or nodules on the skin (1)(2)(3). It is a self-limiting dermatological condition that rarely affects adolescents or adults, but may occasionally recur.…”