Juvenile xanthogranuloma: Case report with immunohistochemical identification of early and late cytomegalovirus antigens.

Abstract

Juvenile xanthogranuloma (JXG) is a dermatological condition of unknown etiology that rarely affects the oral mucosa. There are conflicting reports suggesting that it may represent a reactive virally-induced lesion associated with cytomegalovirus (CMV) infection. The present paper reports an additional case of oral JXG and discusses its possible association with CMV infection. The biotin-streptavidin system was used to detect early and late CMV antigens. Positive immunolabelling for both antigens was demonstrated in some histiocytes in the lesion. These findings suggest that JXG may be associated with CMV infection. (J. Oral Sci. 43, 21 -25 , 2001)

Benign Cephalic Histiocytosis Preceding the Development of Insulin‐dependent Diabetes Mellitus

“…The relationship of BCH to IDDM is not known. It can be speculated that because NLCH is thought to represent a reactive histiocytic process to an infectious agent (8), and IDDM is an autoimmune disorder thought to be triggered by a virus in genetically susceptible individuals (6,7), both diseases could result from a response to a viral infection. We are aware that their coexistence might be purely coincidental, but the fact that both IDDM and BCH are infrequent illnesses, raises the possibility of a nonfortuitous association.…”

Baby with neonatal systemic juvenile xanthogranuloma born within a cross-cousin marriage

“…2 Viral infections such as Cytomegalovirus (CMV) or Varicella has been thought as the trigger factor in some cases. 3,7,8 Neurofibromatosis type 1 (NF1) and juvenile chronic myeloid leukemia may accompany JXG. The incidence of NF1 with JXG is 0.7e18%.…”

An unusual co‐occurrence of Langerhans cell histiocytosis and Rosai–Dorfman disease: report of a case and review of the literature

“…The following explanations have been suggested to account for this unique co‐occurrence: First, the reactive form of one disease in response to inflammation following the other . Non‐LCH is generally considered a reactive disorder secondary to infections and malignancy . RDD was speculated to be reactive to HHV‐6 infection .…”