Juvenile xanthogranuloma associated with cytomegalovirus infection

Balfour, Henry H.; Speicher, Carl E.; McReynolds, Donley G.; Nesbit, Mark E.

doi:10.1016/0002-9343(71)90226-9

Cited by 42 publications

(13 citation statements)

References 12 publications

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“…The most common extracu taneous site is the eye (eyelid, limbus, iris, and optic nerve), but lesions have been reported within the heart, muscula ture, periosteum, pericardium, omentum, mucous mem branes, salivary glands, lung, liver, spleen and testes [4]. It is also associated with neurofibromatosis type 1 [50], juve nile chronic myelogenous leukemia [51], urticaria pigmen tosa [52], and cytomegalovirus infection [53], while sys temic JXG is known to occur without obvious cutaneous disease [39], Prior to this report, only 6 cases of symptom atic CNS involvement as part of systemic JXG have been reported to date [39], Symptoms have included diplopia, ataxia, diabetes insipidus, seizures, and recurrent subdural effusions. In these reports, radiographic abnormalities of the CNS were documented in the hypothalamus and third ventricle, lateral ventricles, cerebral hemispheres, brain stem, and cerebellum; although, only the report of Okubo et al [5] contains histologic confirmation of a true XG.…”

Section: Discussionmentioning

confidence: 99%

Solitary Intracerebral Juvenile Xanthogranuloma

Schultz¹,

Petronio²,

Narad³

et al. 1997

Pediatr Neurosurg

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A case of an intracerebral juvenile xanthogranuloma (JXG) producing complex-partial seizures in a 13-year-old boy is presented. Although the child had no history of JXGs or a systemic histiocytic proliferative disorder, the histopathological and immunocytochemical studies of this lesion were identical to that of a cutaneous JXG. This represents the first description of an isolated intracerebral JXG. On extensive review of the literature, this case comprises only the second reported intracranial lesion and the fourth CNS lesion in a child without cutaneous manifestations of JXG. In contrast to cerebral xanthogranulomas of adulthood, all reported cases of isolated CNS JXG presented with focal symptoms referable to the neuroanatomic localization of the lesion. In this limited series, the magnetic resonance imaging appearance was predictable and consistent, although spinal and intracranial lesions differ with respect to their enhancement with paramagnetic contrast media. While complete surgical excision, if feasible, has been the most utilized form of therapy for symptomatic or progressive lesions, external beam irradiation and cytotoxic chemotherapy have been utilized for unresectable or recurrent disease. Given their rare occurrence and uncertain natural history, it remains unclear whether these solitary CNS lesions represent a distinct clinical entity with a potentially more aggressive clinical course or merely a variant of the systemic non-Langerhans cell histiocytoses.

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Section: Discussionmentioning

confidence: 99%

Solitary Intracerebral Juvenile Xanthogranuloma

Schultz¹,

Petronio²,

Narad³

et al. 1997

Pediatr Neurosurg

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“…Les autres localisations sont moins fréquentes : cavité buccale, trachée, larynx, coeur, viscères abdominaux, muscles squelettiques superficiels, tissus souscutanées et gonades [8]. L'atteinte parotidienne n'a été rapportée que chez deux enfants : un nourrisson de 11 semaines de sexe masculin dans un contexte de parotidite à CMV [4] et un garçon de neuf ans [5]. L'histogenèse de cette tumeur est peu connue.…”

Section: Discussionunclassified

“…D'autres localisations ont été décrites [3]. L'atteinte parotidienne a été rapportée seulement deux fois dans la littérature, et uniquement chez l'enfant [4,5].…”

Section: Introductionunclassified

Xanthogranulome parotidien de l’adulte

Dhouib

Hammami

Sellami

et al. 2010

Revue de Stomatologie et de Chirurgie Maxillo-faciale

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“…One attractive hypothesis is that it is driven by viral infection, and there are several case reports that link JXG to viruses such as cytomegalovirus and varicella. [48][49][50] However, in a series of patients with JXG in which viral infections were investigated, none were found. 51 The relationship between JXG, neurofibromatosis, and leukemias is not understood.…”

Section: Juvenile Xanthogranulomamentioning

confidence: 99%