Juvenile Ossifying Fibroma of the Mandible: a Case Report

Abstract

BackgroundFibro-osseous lesions of the jaws, including juvenile ossifying fibroma, pose diagnostic and therapeutic difficulties due to their clinical, radiological and histological variability. The aim of this study was to report the outcome of a 9 years old girl with diagnosed juvenile ossifying fibroma treatment.MethodsA 9 years old girl presented with a 6 x 8 cm sized hard fixed tumour on right ramus and corpus of the mandible. On the radiological examination tumour showed an irregular but well bordered, unilocular and expansive lesion on the right corpus and ramus of the mandible. There was no teeth displacement or teeth root resorbtion. Microscopically, the tumour had trabeculae, fibrillary osteoid and woven bone. After the clinical, radiological (panoramic radiography, computed tomography and magnetic resonance imaging) and histologic analysis it was diagnosed juvenile ossifying fibroma. In the history of the patient there has been an acute lymphocytic leukaemia in the remission for 3 years.ResultsBecause of large size of mandibular tumour, resultant expansion and destruction of mandibular cortex, the patient underwent right hemimandibulectomy using transmandibular approach. There was no recurrence or complications for two years follow-up.ConclusionsAlthough juvenile ossifying fibroma is an uncommon clinical entity, its aggressive local behaviour and high recurrence rate means that it is important to make an early diagnosis, apply the appropriate treatment and, especially, follow-up the patient over the long-term.

Osteoid producing primary lesion at morphologic and biologic interface

“…In 79% of cases it occurs before 15 yrs of age. Fibroblastic spindle cells constituted stroma with anastomosing areas of cellular condensation, garland like bony strands lined by plump osteoblasts and cement particles are usually present (13,14). Not much atypia or mitotic activity is seen (15).…”

Juvenile Psammomatoid Ossifying Fibroma — A Rare Entity

“…[2] The distinctive features of PsJOF are a predilection for the sinonasal complex and orbit of young people, with an aggressive, infiltrative growth pattern, and a high incidence of recurrence. [2] Here we report a case of Juvenile ossifying fibroma involving the maxilla in a 14 year old boy.…”

“…They can be treated with simple curettage and the recurrence is rare, but in contrast to the form seen at adults, the juvenile ossifying fibroma(JOF) occurs in much younger age and presents as a more aggressive mass with increased recurrence rate. [2] JOF is further subdivided into two distinct histopathologic variants of as Trabecular juvenile ossifying fibroma (TrJOF) and Psammomatoid Juvenile ossifying fibroma (PsJOF). …”

Juvenile Aggressive Ossifying Fibroma: A Rare Case Report

“…The ossifying fibromas are subdivided into conventional and juvenile clinicopathologic subtypes. 2 Juvenile ossifying fibroma is a rare fibro-osseous neoplasm that arises within the craniofacial bones in individuals under 15 years of age. It is usually asymptomatic achieving a large size and exhibiting aggressive behavior and is often diagnosed as juvenile ossifying fibroma, aggressive ossifying fibroma or active ossifying fibroma in the literature.…”