Juvenile‐onset and adult‐onset demodicosis in dogs in the UK: prevalence and breed associations

O'Neill, D G; Turgoose, Emily; Church, David; Brodbelt, David; Hendricks, Anke

doi:10.1111/jsap.13067

Cited by 22 publications

(29 citation statements)

References 47 publications

(123 reference statements)

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“…Brachycephalic dogs were generally younger and lighter than the other three groups. The probability of the occurrence of many disorders in dogs is strongly associated with age and bodyweight; for example osteoarthritis, heart disease, lipoma, hyperadrenocorticism, urinary incontinence, dystocia, cruciate disease and patellar luxation 12 , 24 , 25 , 27 , 28 , 40 , 52 – 58 . Confounders are defined as factors associated with both the risk factor and the outcome of interest but that are not on the causal pathway 21 .…”

Section: Discussionmentioning

confidence: 99%

“…It is possible this approach may lead to false positive and false negative findings 26 . Many of the more recent VetCompass studies of canine health have highlighted the complexity underlying disorder risk, with variables such as age, bodyweight, neutering and insurance status commonly associated with disease risk factors in addition to breed effects 14 , 24 , 27 – 29 . As such, the secondary aim of the study was to compare the consistency of findings between univariable versus multivariable analyses to assist in gaining a deeper understanding of the reliability of univariable analyses for robust inference on factors related to dog health.…”

Section: Introductionmentioning

confidence: 99%

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Unravelling the health status of brachycephalic dogs in the UK using multivariable analysis

O’Neill

Pegram

Crocker

et al. 2020

Sci Rep

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Brachycephalic dog breeds are regularly asserted as being less healthy than non-brachycephalic breeds. Using primary-care veterinary clinical data, this study aimed to identify predispositions and protections in brachycephalic dogs and explore differing inferences between univariable and multivariable results. All disorders during 2016 were extracted from a random sample of 22,333 dogs within the VetCompass Programme from a sampling frame of 955,554 dogs under UK veterinary care in 2016. Univariable and multivariable binary logistic regression modelling explored brachycephaly as a risk factor for each of a series of common disorders. Brachycephalic dogs were younger, lighter and less likely to be neutered than mesocephalic, dolichocephalic and crossbred dogs. Brachycephalic differed to non-brachycephalic types in their odds for 10/30 (33.33%) common disorders. Of these, brachycephalic types were predisposed for eight disorders and were protected for two disorders. Univariable and multivariable analyses generated differing inference for 11/30 (30.67%) disorders. This study provides strong evidence that brachycephalic breeds are generally less healthy than their non-brachycephalic counterparts. Results from studies that report only univariable methods should be treated with extreme caution due to potential confounding effects that have not been accounted for during univariable study design or analysis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unravelling the health status of brachycephalic dogs in the UK using multivariable analysis

O’Neill

Pegram

Crocker

et al. 2020

Sci Rep

Self Cite

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“…Epidemiological analyses of primary care veterinary data offer many advantages, including access to large volumes of clinical data that are contemporaneously recorded at the time of the clinical events by veterinary professionals and where diagnoses are updated over time as new information comes available [ 13 ]. The pace of publication of research based on these primary care clinical data is currently accelerating [ 16 – 19 ] and is contributing substantially to improved clinical practice activities [ 20 , 21 ] and breed health reforms [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of commonly diagnosed disorders in UK dogs under primary veterinary care: results and applications

et al. 2021

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Background Although dogs are a commonly owned companion animal in the UK, the species experiences many health problems that are predictable from demographic information. This study aimed to use anonymised veterinary clinical data from the VetCompass™ Programme to report the frequency of common disorders of dogs under primary veterinary care in the UK during 2016 and to explore effects associated with age, sex and neuter status. Results From an available population of 905,543 dogs under veterinary care at 886 veterinary clinics during 2016, the current study included a random sample of 22,333 (2.47 %) dogs from 784 clinics. Prevalence for each disorder was calculated at the most refined level of diagnostic certainty (precise-level precision) and after grouping to a more general level of diagnostic precision (grouped-level precision). The most prevalent precise-level precision disorders recorded were periodontal disease (prevalence 12.52 %, 95 % CI: 12.09–12.97), otitis externa (7.30 %, 95 % CI: 6.97–7.65) and obesity (7.07 %, 95 % CI: 6.74–7.42). The most prevalent grouped-level disorders were dental disorder (14.10 %, 95 % CI: 13.64–14.56), skin disorder (12.58 %, 95 % CI: 12.15–13.02) and enteropathy (10.43 %, 95 % CI: 10.04–10.84). Associations were identified for many common disorders with age, sex and neuter. Conclusions The overall findings can assist veterinarians and owners to prioritise preventive care and to understand demographic risk factors in order to facilitate earlier diagnosis of common disorders in dogs. The information on associations with age, sex and neuter status provides additional contextual background to the complexity of disorder occurrence and supports targeted health controls for demographic subsets of dogs.

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“…At a grouped-level of diagnostic precision, SBTs showed predisposition to skin disorders (OR 1.18). Whilst this would include atopic dermatitis, and possible alternative diagnostic terms used for atopy, SBTs have previously been identified with predisposition to juvenile-onset demodicosis [ 38 , 39 ]. Demodicosis did not feature within the top 30 specific disorders in SBTs or non-SBTs, however may have been included within skin disorders at a grouped-level.…”

Section: Discussionmentioning

confidence: 99%

Staffordshire Bull Terriers in the UK: their disorder predispositions and protections

Pegram

Wonham²,

Brodbelt

et al. 2020

Canine Genet Epidemiol

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Background The Staffordshire Bull Terrier is a popular dog breed in the UK but there is limited reliable evidence on disorder predispositions and protections within the breed. Using anonymised veterinary clinical data from the VetCompass™ Programme, this study aimed to identify common disorders with predisposition and protection in the Staffordshire Bull Terrier. The study hypothesised that Staffordshire Bull Terriers would have higher odds of aggression compared with non-Staffordshire Bull Terriers. Results The clinical records of a random sample of dogs of all types were reviewed to extract the most definitive diagnoses for all disorders existing during 2016. A combined list from the 30 most common disorders in Staffordshire Bull Terriers and the 30 most common disorders in non-Staffordshire Bull Terriers was generated. Multivariable logistic regression was used to report the odds of each of these disorders in 1304 (5.8%) Staffordshire Bull Terriers compared with 21,029 (94.2%) non-Staffordshire Bull Terriers. After accounting for confounding, Staffordshire Bull Terriers had significantly increased odds of 4/36 (11.1%) disorders compared to non-Staffordshire Bull Terriers with highest odds for seizure disorder (OR 2.06; 95% CI 1.24 to 3.40; p = 0.005). Conversely, Staffordshire Bull Terriers had reduced odds of 5/36 (13.9%) disorders, with lowest odds for patellar luxation (OR 0.15; 95% CI 0.04 to 0.61; p = 0.008). There was no significant difference in the odds of aggression between Staffordshire Bull Terriers compared with non-Staffordshire Bull Terriers (OR 1.09; 95% CI 0.75 to 1.58; p = 0.644). Conclusions This study provides a reliable evidence base of breed-specific disorder predispositions and protections that can be used by breeders to optimise breeding decisions. The findings can assist prospective owners of Staffordshire Bull Terriers to make informed decisions when acquiring a dog. From the relative number of predispositions to protections identified, there is no evidence that Staffordshire Bull Terriers have higher overall health problems than non-Staffordshire Bull Terriers.

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Juvenile‐onset and adult‐onset demodicosis in dogs in the UK: prevalence and breed associations

Cited by 22 publications

References 47 publications

Unravelling the health status of brachycephalic dogs in the UK using multivariable analysis

Unravelling the health status of brachycephalic dogs in the UK using multivariable analysis

Prevalence of commonly diagnosed disorders in UK dogs under primary veterinary care: results and applications

Staffordshire Bull Terriers in the UK: their disorder predispositions and protections

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